Search Clinical Trials
Before medications are approved by the U.S. Food and Drug Administration (FDA) or before certain therapy methods are widely accepted as effective, they are tested on people who volunteer to participate in a clinical trial.
Organizations across the country are looking for people like you to take part in their research studies. The list of studies below have been selected from ClinicalTrials.gov based on their inclusion of one or more of the following terms: anxiety disorders, depression, OCD, PTSD, and bipolar disorder.
The Anxiety and Depression Association of America (ADAA) is supportive of research that is conducted through clinical trials. Participating in research can potentially help change the mental health outcomes for you and others who suffer anxiety, depression, and related disorders. You may learn about new interventions/treatments that are being considered. This website page is brought to you in partnership with ResearchMatch.
Sponsor Condition of Interest |
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Open Label Optimization Study
Magnus Medical
Major Depressive Disorder
The goal of this observational study is to demonstrate effectiveness in the treatment of
Major Depressive Disorder
The primary objective is to assess the effectiveness in the treatment of Major Depressive
Disorder using the CGI-I at the end of the treatment
Participants will receive 10 treatments... expand
The goal of this observational study is to demonstrate effectiveness in the treatment of Major Depressive Disorder The primary objective is to assess the effectiveness in the treatment of Major Depressive Disorder using the CGI-I at the end of the treatment Participants will receive 10 treatments per day for 5 days (M-F) of SAINT® Type: Observational Start Date: Apr 2023 |
Whole Health in VA Mental Health: Omnis Salutis
VA Office of Research and Development
Stress Disorders, Post-Traumatic
Depressive Disorder
Anxiety Disorders
Substance-Related Disorders
Recent Veterans of the Afghanistan and Iraq conflicts are presenting in VA care with high
rates of posttraumatic stress disorder (PTSD), depression, anxiety, and substance use
disorders. Difficulties with social relationships and community reintegration are common
functional impairments with these... expand
Recent Veterans of the Afghanistan and Iraq conflicts are presenting in VA care with high rates of posttraumatic stress disorder (PTSD), depression, anxiety, and substance use disorders. Difficulties with social relationships and community reintegration are common functional impairments with these disorders. VA is transforming to a Whole Health, patient-centered system of care that will address these issues as part of health care. In a previous study, Omnis Salutis (OS) was developed with Veteran and clinician input. OS is a three-session intervention in which Veterans learn about Whole Health and practice communicating their health mission to providers and social supports. OS was shown feasible to deliver, acceptable to Veterans, and preliminarily effective at improving physical, mental, and social functioning. This study will use a large, multisite randomized controlled trial to test the impact of OS on Veterans' social and physical functioning and Veteran engagement in mental health care. Results will support broad delivery of OS throughout the VA. Type: Interventional Start Date: Feb 2023 |
Feasibility Trial of Tele-IPT and Tele-Pharmacotherapy for Patients With Depression and Non-Metastatic...
New York State Psychiatric Institute
Major Depressive Disorder
Breast Cancer
Venlafaxine
Cancer and depression commonly occur together, and each worsens the other. We conducted a
large psychotherapy study treating depression in breast cancer patients, showing that
psychotherapy lowers symptoms. Surprisingly, no studies have compared depression-focused
psychotherapy to antidepressant medication... expand
Cancer and depression commonly occur together, and each worsens the other. We conducted a large psychotherapy study treating depression in breast cancer patients, showing that psychotherapy lowers symptoms. Surprisingly, no studies have compared depression-focused psychotherapy to antidepressant medication for patients with breast cancer and depression. We applied to the National Cancer Institute for a large, cross-national grant. Reviewers asked us to first demonstrate that patients would accept either psychotherapy or medication as treatment. Thanks to funding from the Columbia Herbert Irving Cancer Center, we will test this study approach. We will randomly assign 20 patients with both non-metastatic breast cancer and major depression to 12 weeks of tele-therapy (by Zoom) with either interpersonal psychotherapy or a serotonin reuptake inhibitor. We expect patients in both treatments to report improvement in depression symptoms. We will also measure C-reactive protein, a blood test of inflammation elevated in both cancer and depression, which may predict medication response. Type: Interventional Start Date: Mar 2022 |
Virtual Neuro-Navigation System for Personalized Community Based TMS
Soterix Medical
Treatment Resistant Depression
Phase I study of a virtual neuro-navigation package with built-in support for identifying
specific "surface-based" targets to optimze TMS treatment. expand
Phase I study of a virtual neuro-navigation package with built-in support for identifying specific "surface-based" targets to optimze TMS treatment. Type: Interventional Start Date: Jul 2021 |
Intervention to Prevent Peer Violence & Depressive Symptoms Among At-Risk Adolescents
Rhode Island Hospital
Depressive Disorder
Violence
The purpose of this investigation is to test the efficacy of "iDOVE2" (a brief emergency
department introductory session and longitudinal automated text-message depression
prevention program for high-risk teens), and to determine the most potent and
parsimonious combination of intervention components... expand
The purpose of this investigation is to test the efficacy of "iDOVE2" (a brief emergency department introductory session and longitudinal automated text-message depression prevention program for high-risk teens), and to determine the most potent and parsimonious combination of intervention components for preventing peer violence and depressive symptoms among at-risk youth. Type: Interventional Start Date: Aug 2018 |
Viome Precision Nutritional Programs to Improve Clinical Outcomes for Mental Health Conditions
Viome
Mental Health Issue
Mental Health Disorder
Mental Health
Depression
Depression, Anxiety
US residents who have obesity and sign the informed consent form and are screened and
enrolled for this study. Participants who are enrolled complete a survey upon enrollment
and are randomized into one of two arms. This study is direct to participant and will not
utilize clinical sites. expand
US residents who have obesity and sign the informed consent form and are screened and enrolled for this study. Participants who are enrolled complete a survey upon enrollment and are randomized into one of two arms. This study is direct to participant and will not utilize clinical sites. Type: Interventional Start Date: Oct 2023 |
Mindfulness Intervention in Orthopedic Trauma Patients
University of Utah
Pain
Anxiety
This project a single-site 3-arm parallel group randomized clinical trial conducted at a
tertiary level 1 trauma center among patients undergoing operative fixation of a lower
extremity fracture. expand
This project a single-site 3-arm parallel group randomized clinical trial conducted at a tertiary level 1 trauma center among patients undergoing operative fixation of a lower extremity fracture. Type: Interventional Start Date: Nov 2022 |
Beyond Monoamines: The Role of the Nociceptin/Orphanin FQ Receptor in Major Depression
Mclean Hospital
Major Depressive Disorder
This study looks at the role of the Nociceptin/Orphanin FQ receptor system in the brain
of individuals with current or past major depressive disorder (MDD). It also examines how
individuals with a history of depression make certain decisions and which brain regions
are involved in such decisions.... expand
This study looks at the role of the Nociceptin/Orphanin FQ receptor system in the brain of individuals with current or past major depressive disorder (MDD). It also examines how individuals with a history of depression make certain decisions and which brain regions are involved in such decisions. Information collected through MRI, PET, biospecimens (i.e., blood, saliva) and behavioral tasks will be used to predict depressive symptoms in the future. Type: Observational Start Date: Dec 2021 |
The Impact of Medical Play in the Dental Clinic Setting on the Cooperation of Neurotypical Patients
University of Colorado, Denver
Dental Phobia
Dental Anxiety
Oral Aversion
The purpose of this pilot study is to investigate the efficacy of medical play in the
dental setting to improve the behaviors and cooperation of neurotypical patients during
dental visits.
The specific aims of the study are as follows:
1. To evaluate differences in behaviors and cooperation... expand
The purpose of this pilot study is to investigate the efficacy of medical play in the dental setting to improve the behaviors and cooperation of neurotypical patients during dental visits. The specific aims of the study are as follows: 1. To evaluate differences in behaviors and cooperation levels of subjects utilizing medical play before a routine dental exam visit in comparison to those undergoing a routine dental exam visit without use of medical play. 2. To evaluate whether subjects who have a dental exam visit, with or without use of medical play, show improved behaviors and improved completion of components of the dental exam compared to their previous routine dental visit. 3. To evaluate provider perceptions of the behavior and cooperation of children using medical play before dental exam visits compared to dental exam visits without medical play. 4. To evaluate caregiver perceptions of the behavior and cooperation of children using medical play before dental exam visits compared to dental exam visits without medical play. 5. To evaluate patient perceptions of the dental exam, visit when medical play is used in comparison to dental exam visits without medical play. The hypotheses are as follows: 1. Subjects will have increased positive behaviors and improved cooperation during dental exam visits when medical play is utilized beforehand. 2. Providers will report improved behavior and cooperation from patients when medical play is utilized beforehand. 3. Parents will report improved behavior and cooperation from their children and report greater satisfaction with the dental visit when medical play is utilized beforehand. 4. Patients will report experiencing less anxiety, via the Modified Child Dental Anxiety Scale - Faces Version (MCDAS-f) after appointments in which medical play is utilized. Type: Interventional Start Date: Oct 2022 |
Integrated Tele-Behavioral Activation and Fall Prevention for Low-income Homebound Seniors With Depression
University of Texas at Austin
Depression, Unipolar
Fall
This study will test clinical and cost effectiveness of an integrated tele- and
bachelor's-level counselor/coach delivered behavioral activation (BA) and fall prevention
(FP) for low-income homebound older adults. The long-term objective of the proposed study
is to improve access to depression treatment... expand
This study will test clinical and cost effectiveness of an integrated tele- and bachelor's-level counselor/coach delivered behavioral activation (BA) and fall prevention (FP) for low-income homebound older adults. The long-term objective of the proposed study is to improve access to depression treatment and fall prevention for growing numbers of low-income homebound seniors. We plan to recruit 320 low-income, racially diverse homebound seniors who are served by a home-delivered meal (HDM) program and other aging-service agencies in Central Texas. In a 4-arm, pragmatic clinical trial with randomization prior to consent, the participants in the integrated Tele-BA and FP (TBF hereafter) arm will receive 5 Tele-BA sessions and 4 in-home FP sessions. Those in the Tele-BA or FP alone arms will receive the respective intervention and 4 bimonthly telephone check-in (booster) calls, and those in the Attention Control (AC) arm will receive 5 weekly telephone check-in calls followed by 4 bimonthly follow-up calls. Follow-up assessments will be at 12, 24, and 36 weeks after baseline. Type: Interventional Start Date: Nov 2021 |
Auriculotherapy in the Treatment of Pre-Operative Anxiety
Jacques E. Chelly
Anxiety Preoperative
The goal of this clinical trial is to use the validated PROMIS Emotional Distress -
Anxiety - Short Form 8a and PROMIS Emotional Distress-Depression-Short Form pre-and
post-intervention to establish a superior correlation between the auriculotherapy
treatment and the reduction of perioperative anxiety.... expand
The goal of this clinical trial is to use the validated PROMIS Emotional Distress - Anxiety - Short Form 8a and PROMIS Emotional Distress-Depression-Short Form pre-and post-intervention to establish a superior correlation between the auriculotherapy treatment and the reduction of perioperative anxiety. Subject population will include those having a partial or total nephrectomy for cancer. Drawing the role that auriculotherapy may play in reducing perioperative anxiety related requirement after surgery may also help in reducing the risk of opioid use disorders (OUD) since anxiety has been found to be a major risk factor for OUD in surgical patients. Therefore, this trial will also examine the effect of the auriculotherapy intervention in reducing opioid requirement after surgery. Type: Interventional Start Date: Apr 2021 |
Assessment and Treatment for Chronic Pain in Veterans With Serious Mental Illness
VA Office of Research and Development
Chronic Pain
Schizophrenia
Psychotic Disorders
Bipolar Disorder
Affective Disorders, Psychotic
Chronic pain has a highly negative impact on Veterans, especially those with serious
mental illness (SMI). Chronic pain leads to poorer mental health and physical
functioning, and represents a critical obstacle to rehabilitation and recovery. Despite
known high prevalence rates of chronic pain in... expand
Chronic pain has a highly negative impact on Veterans, especially those with serious mental illness (SMI). Chronic pain leads to poorer mental health and physical functioning, and represents a critical obstacle to rehabilitation and recovery. Despite known high prevalence rates of chronic pain in SMI populations, there is little research to: a) evaluate nonpharmacological pain management strategies in this population, and b) examine directional relations between chronic pain and SMI symptoms. This study aims to address research and clinical gaps by: a) testing the feasibility and acceptability of Cognitive Behavioral Therapy for Chronic Pain (CBT-CP) - a VA evidence-based psychotherapy for chronic pain - in Veterans with SMI, and b) better assessing the complex relation between chronic pain and psychiatric symptoms and their impact on functioning. Results from this study will inform us as to whether CBT-CP is feasible to implement, acceptable to Veterans with SMI, and worth examining in its standard or in an optimized form in a larger clinical trial. Type: Interventional Start Date: Mar 2021 |
ON/OFF Stimulation and Reward Motivation in Patients With Deep Brain Stimulators
Massachusetts General Hospital
Obsessive Compulsive Disorder
Major Depressive Disorder
Epilepsy
We propose to study approach/avoidance behavior as measured by the Approach Avoidance
task in 20 epilepsy patients undergoing implementation of depth electrodes for seizure
monitoring in the Epilepsy Monitoring Unit at MGH. We will also study the effects of
VC/VS electrical stimulation on approach-avoidance... expand
We propose to study approach/avoidance behavior as measured by the Approach Avoidance task in 20 epilepsy patients undergoing implementation of depth electrodes for seizure monitoring in the Epilepsy Monitoring Unit at MGH. We will also study the effects of VC/VS electrical stimulation on approach-avoidance conflict in 20 adult patients who have undergone DBS implantation for severe MDD and/or OCD. There are 100-200 patients in the world with DBS electrodes in the VC/VS, and our research team cares for more than any other institution. Both participant groups will be assessed with respect to reward-aversion decision conflict using the task. The task will be performed with concurrent EEG recordings in DBS patients, and with continuous recording through our invasive neurophysiology rig in EMU subjects. Type: Interventional Start Date: Jan 2021 |
The Effects of Noninvasive Neuromodulation on Mental Wellness, Behavior, and Electrophysiology
Sanmai Technologies PBC dba Sanmai
Anxiety Disorders
The purpose of the study is to test the effects of brief, low-intensity transcranial
focused ultrasound (TUS) on electrophysiological, behavioral, and cognitive markers
related to anxiety disorders. expand
The purpose of the study is to test the effects of brief, low-intensity transcranial focused ultrasound (TUS) on electrophysiological, behavioral, and cognitive markers related to anxiety disorders. Type: Interventional Start Date: Apr 2023 |
Acute Alcohol Response In Bipolar Disorder: a Longitudinal Alcohol Administration/fMRI Study
University of Texas at Austin
Bipolar Disorder
Alcohol Drinking
Alcohol Use Disorder
Alcohol use disorders (AUDs) affect up to 60% of individuals with bipolar disorder during
their lifetime and is associated with worse illness outcomes, yet few studies have been
performed to clarify the causes of this comorbidity. Understanding biological risk
factors that associate with and predict... expand
Alcohol use disorders (AUDs) affect up to 60% of individuals with bipolar disorder during their lifetime and is associated with worse illness outcomes, yet few studies have been performed to clarify the causes of this comorbidity. Understanding biological risk factors that associate with and predict the development of AUDs in bipolar disorder could inform interventions and prevention efforts to reduce the rate of this comorbidity and improve outcomes of both disorders. Identifying predictors of risk requires longitudinal studies in bipolar disorder aimed at capturing the mechanisms leading to the emergence of AUDs. Previous work in AUDs suggest that subjective responses to alcohol and stress-related mechanisms may contribute to the development of AUDs. In bipolar disorder, altered developmental trajectory of critical ventral prefrontal networks that modulate mood and reward processing may alter responses to alcohol and stressors; consequently, the disruption in typical neurodevelopment may be an underlying factor for the high rates of comorbidity. No longitudinal data exist investigating if this developmental hypothesis is correct. To address this gap, the investigators will use a multimodal neuroimaging approach, modeling structural and functional neural trajectories of corticolimbic networks over young adulthood, incorporating alcohol administration procedures, clinical phenotyping, and investigating effects of acute stress exposure and early life stress. Research aims are to identify biological risk factors-i.e., changes in subjective response to alcohol and associated neural trajectories-that are associated with the development of alcohol misuse and symptoms of AUDs over a two-year longitudinal period in young adults with bipolar disorder and typical developing young adults. Longitudinal data will be collected on 160 young adults (50% with bipolar disorder, 50% female; aged 21-26). This study is a natural extension of the PI's K01 award. How acute exposure to stress and childhood maltreatment affects subjective response to alcohol and risk for prospective alcohol misuse and symptoms of AUDs will be investigated. The investigators will test our hypothesis that developmental differences in bipolar disorder versus typical developing individuals disrupt corticolimbic networks during young adulthood, increase sensitivity to stress, and lead to changes in subjective response to alcohol and placebo response increasing risk for developing AUDs. Type: Interventional Start Date: Jul 2023 |
Evaluating Buspirone to Treat Opioid Withdrawal
Johns Hopkins University
Opioid Use Disorder
Opioid Withdrawal
Opioid Craving
Anxiety
The investigators propose a rigorous, Phase II, three-group, placebo-controlled
double-blind randomized controlled trial (RCT) to evaluate the efficacy of buspirone for
both withdrawal and craving among individuals with opioid use disorder (OUD) undergoing a
standardized stepwise taper. During this... expand
The investigators propose a rigorous, Phase II, three-group, placebo-controlled double-blind randomized controlled trial (RCT) to evaluate the efficacy of buspirone for both withdrawal and craving among individuals with opioid use disorder (OUD) undergoing a standardized stepwise taper. During this 10 to 12-day residential study, participants with OUD will be enrolled, stabilized on a short-acting opioid, undergo an opioid stepwise taper, and complete a post-taper observation period where participants will have the opportunity to initiate long-term buprenorphine or extended-release naltrexone. Type: Interventional Start Date: Dec 2022 |
Methylphenidate for Ptsd and Stroke Veterans
VA Office of Research and Development
PTSD
Stroke
Veterans with post-traumatic stress disorder (PTSD) have an increased risk of developing
ischemic stroke. Veterans enduring PTSD face difficulties in managing their PTSD severity
after suffering from a stroke. Currently, clinical trials in PTSD exclude patients with
stroke and patients with significant... expand
Veterans with post-traumatic stress disorder (PTSD) have an increased risk of developing ischemic stroke. Veterans enduring PTSD face difficulties in managing their PTSD severity after suffering from a stroke. Currently, clinical trials in PTSD exclude patients with stroke and patients with significant premorbid psychological conditions like PTSD are usually excluded from stroke clinical trials. Methylphenidate (MPH) is a central nervous system stimulant that can improve PTSD symptoms: avoidance behaviors, social withdrawal, hyperarousal, and working memory. MPH can also improve post-stroke outcomes: mood, activities of daily living, and motor functioning. In clinical trials for PTSD or stroke, MPH has been shown to be well-tolerated with minimal adverse events. The high prevalence of PTSD in Veterans with stroke provides strong justification for development of interventions that effectively and simultaneously target both conditions. The overarching goal of our proposal is to understand how MPH improves PTSD severity in Veterans with comorbid stroke. Type: Interventional Start Date: Jan 2022 |
Managing Anxiety in Pediatric Primary Care (MAPP)
UConn Health
Anxiety
Anxiety Disorders
The goal of this clinical trial is to conduct a randomized controlled trial to enhance
the capacity of pediatric primary care providers to assist their patients who struggle
with anxiety.
The study aims to refine and assess the feasibility of the Anxiety Action Plan (AxAP), a
brief intervention... expand
The goal of this clinical trial is to conduct a randomized controlled trial to enhance the capacity of pediatric primary care providers to assist their patients who struggle with anxiety. The study aims to refine and assess the feasibility of the Anxiety Action Plan (AxAP), a brief intervention to reduce pediatric anxiety, delivered by primary care providers (PCPs) in community pediatric primary care clinics. The goal of the AxAP is to enhance the capacity of PCPs to identify and intervene with anxious youth, which will enhance access to care in general and especially in locations with few mental health specialists. PCPs participating in this study will attend a training, administer the intervention to enrolled youth assigned to the MAPP condition, participate in coaching sessions, and fill out study questionnaires. Families participating in this study will complete evaluations with the study team, receive the intervention from their PCP (if assigned to the MAPP condition), and fill out study questionnaires. Researchers will compare the MAPP intervention to Enhanced Usual Care (EUC; consisting of videos, handouts, and other resources for anxiety reduction) to see the differences, if any, in child outcomes. Type: Interventional Start Date: Nov 2023 |
MBCT Intervention: Healthy Mind, Healthy Living
University of Washington
Mindfulness Based Cognitive Therapy
Depression
Sleep
Anxiety Depression
Depression among older Korean Americans are rising. Mindfulness-based cognitive therapy
(MBCT) is an evidence-based intervention (EBI), effective for preventing depression
relapse and reducing depressive symptoms. To enhance feasibility, acceptability, and
reach, a brief version of MBCT has been developed... expand
Depression among older Korean Americans are rising. Mindfulness-based cognitive therapy (MBCT) is an evidence-based intervention (EBI), effective for preventing depression relapse and reducing depressive symptoms. To enhance feasibility, acceptability, and reach, a brief version of MBCT has been developed and delivered by telephone (brief MBCT-T), but has only been tested in primarily White samples. This study will test test the effect of brief MBCT-T among older Korean Americans. Type: Interventional Start Date: Apr 2023 |
Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy
Washington University School of Medicine
Treatment Resistant Depression
Electroconvulsive therapy (ECT) alleviates treatment-resistant depression (TRD) through
repeated generalized seizures. The goal of this study is to evaluate how ECT impacts
sleep-wake regulation and efficiency of information transfer in functional networks in
different states of arousal. expand
Electroconvulsive therapy (ECT) alleviates treatment-resistant depression (TRD) through repeated generalized seizures. The goal of this study is to evaluate how ECT impacts sleep-wake regulation and efficiency of information transfer in functional networks in different states of arousal. Type: Observational Start Date: Mar 2023 |
Brief Interventions for Coping With Distress
Teachers College, Columbia University
Distress, Emotional
Emotional Dysfunction
Anxiety
Depression
This study is being done to compare the effectiveness of three different skills trainings
to cope with distress. These three trainings are: 1) an attention skills training, 2) an
attention and reflective thought skills training, and 3) a health and wellness education
training. expand
This study is being done to compare the effectiveness of three different skills trainings to cope with distress. These three trainings are: 1) an attention skills training, 2) an attention and reflective thought skills training, and 3) a health and wellness education training. Type: Interventional Start Date: May 2023 |
Perinatal Research on Improving Sleep and Mental Health
University of California, San Francisco
Insomnia
Depression
The goal of this clinical trial is to compare two sleep programs in pregnant people with
insomnia. The main questions it aims to answer are:
1. What is the efficacy of digital cognitive behavioral therapy for insomnia (CBT-I)
versus digital sleep hygiene education (SHE) for preventing perinatal... expand
The goal of this clinical trial is to compare two sleep programs in pregnant people with insomnia. The main questions it aims to answer are: 1. What is the efficacy of digital cognitive behavioral therapy for insomnia (CBT-I) versus digital sleep hygiene education (SHE) for preventing perinatal depression? 2. Is the effect of digital CBT-I on perinatal depression mediated through prenatal insomnia symptom improvement? 3. Is the effect of digital CBT-I on perinatal depression moderated by baseline depressive symptom severity? Participants will receive one of two sleep programs - SHE or CBT-I. Both involve six weekly online sessions. Participants will complete surveys and interviews until 1 year postpartum. Type: Interventional Start Date: Nov 2022 |
Compassion Meditation vs. Health Education for Veterans
VA Office of Research and Development
Chronic Pain
Stress Disorders, Posttraumatic
Depression
Chronic pain (CP) is a major health problem for military Veterans, and CP is often
associated with comorbid mental health problems, including posttraumatic stress disorder
(PTSD) and depression. CP with psychological comorbidity is associated with increased
healthcare costs, medication use, risk of... expand
Chronic pain (CP) is a major health problem for military Veterans, and CP is often associated with comorbid mental health problems, including posttraumatic stress disorder (PTSD) and depression. CP with psychological comorbidity is associated with increased healthcare costs, medication use, risk of suicide and rates of disability and reduced quality of life. Current empirically supported treatments do not always lead to substantial improvements (up to 50% of patients drop out or are do not respond to treatment). This project was designed to evaluate the efficacy of a novel intervention for addressing these challenges. Compassion meditation (CM), a meditative practice that focuses on the wish to remove suffering, is a contemplative practice that has promise for the amelioration of physical and mental health problems as well as promoting positive affect and improving quality of life. This study will evaluate the efficacy of Cognitively-Based Compassion Training for Chronic Pain with Psychological Comorbidity (CBCT-CP+) compared to Health Education while Living with Pain (H.E.L.P.) control condition, in a sample of among Veterans with CP conditions and psychological comorbidity. Type: Interventional Start Date: Jan 2022 |
Wraparound for High-risk Families With Substance Use Disorders: Examining Family, Child, and Parent Outcomes
Dartmouth-Hitchcock Medical Center
Substance-Related Disorders
Depression
Stress Disorders, Post-Traumatic
Child Abuse
Child Neglect
The investigators propose a Hybrid Type 1 effectiveness-implementation quasi-experimental
trial. Participants are drawn from two different communities contemporaneously. The
intervention participants in one community receive a Wraparound intervention. Comparison
group participants drawn from a second... expand
The investigators propose a Hybrid Type 1 effectiveness-implementation quasi-experimental trial. Participants are drawn from two different communities contemporaneously. The intervention participants in one community receive a Wraparound intervention. Comparison group participants drawn from a second matched community receive treatment as usual. With this design, the investigators aim to study outcomes associated with the intervention as well as explore important facilitators and barriers associated with the implementation and other factors associated with reach / participation, engagement and acceptability. Wraparound is a structured 12-month family-driven "process" that is guided by family goals, includes a team of supports to wrap around families, and coordinates care for families. Wraparound has been primarily delivered and tested with families of older-age children with severe emotional and behavioral needs in an attempt to prevent residential placement. The investigators are interested in testing the model in a sample of families (n=160) affected by substance use disorders who have children placed outside the home or are at risk of such placement. The investigators hypothesize that families receiving Wraparound will obtain better parenting and family functioning outcomes (primary outcome); child safety, permanency, and well-being; and parental recovery than families receiving treatment as usual. The investigators will also explore factors associated with higher levels of engagement and outcomes, including family characteristics, referral sources and hand-off, and similarly, explore barriers and facilitators associated with engagement and/or outcomes. Type: Interventional Start Date: Nov 2020 |
POST Facilitation for Community Dwelling Older Adults (POST-RCT)
Indiana University
Anxiety
Depression
Post Traumatic Stress Disorder
Satisfaction
We propose to study the effects of Physician Orders for Scope of Treatment (POST)
Facilitation in a randomized controlled trial in a population of community dwelling older
adults who qualify for POLST facilitation, including those with normal cognition and
those with Alzheimer's Disease and Related... expand
We propose to study the effects of Physician Orders for Scope of Treatment (POST) Facilitation in a randomized controlled trial in a population of community dwelling older adults who qualify for POLST facilitation, including those with normal cognition and those with Alzheimer's Disease and Related Disorders. Type: Interventional Start Date: May 2020 |
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