Search Clinical Trials
Before medications are approved by the U.S. Food and Drug Administration (FDA) or before certain therapy methods are widely accepted as effective, they are tested on people who volunteer to participate in a clinical trial.
Organizations across the country are looking for people like you to take part in their research studies. The list of studies below have been selected from ClinicalTrials.gov based on their inclusion of one or more of the following terms: anxiety disorders, depression, OCD, PTSD, and bipolar disorder.
The Anxiety and Depression Association of America (ADAA) is supportive of research that is conducted through clinical trials. Participating in research can potentially help change the mental health outcomes for you and others who suffer anxiety, depression, and related disorders. You may learn about new interventions/treatments that are being considered. This website page is brought to you in partnership with ResearchMatch.
Sponsor Condition of Interest |
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Multi-modal Assessment of Gamma-aminobutyric Acid (GABA) Function in Psychosis
University of Michigan
Schizophrenia
Bipolar Disorder
Healthy
Psychosis
Schizophreniform Disorders
The purpose of this study is to better understand mental illness and will test the
hypotheses that while viewing affective stimuli, patient groups will show increased blood
oxygenation level dependent (BOLD) signal by fMRI after lorazepam.
This study will enroll participants between the ages of... expand
The purpose of this study is to better understand mental illness and will test the hypotheses that while viewing affective stimuli, patient groups will show increased blood oxygenation level dependent (BOLD) signal by fMRI after lorazepam. This study will enroll participants between the ages of 16 and 60, who have a psychotic illness (such as psychosis which includes conditions like schizophrenia, schizoaffective disorder, and mood disorders). The study will also enroll eligible participants without any psychiatric illness, to compare their brains. The study will require participants to have 3-4 sessions over a few weeks. The initial assessments (may be over two visits) will include a diagnostic interview and several questionnaires (qols) to assess eligibility. Subsequently, there will will be two separate functional magnetic resonance imaging (fMRI) sessions in which lorazepam or placebo will be given prior to the MRI. During the fMRI the participants will also be asked to answer questions. Additionally, the participants will have their blood drawn, women of child bearing potential will have a urine pregnancy test, vital signs taken, and asked to complete more qols. Type: Interventional Start Date: Jan 2020 |
A Mobile Intervention for Black Individuals Who Engage in Hazardous Drinking
University of Houston
Alcohol Abuse
Anxiety
The purpose of this study is to develop and examine a culturally adapted, mobile health
application for the Android and iOS platform. The application uses a personalized
feedback intervention (PFI) designed to enhance knowledge regarding adverse
anxiety-alcohol interrelations, increase motivation... expand
The purpose of this study is to develop and examine a culturally adapted, mobile health application for the Android and iOS platform. The application uses a personalized feedback intervention (PFI) designed to enhance knowledge regarding adverse anxiety-alcohol interrelations, increase motivation and intention to reduce hazardous drinking, and reduce positive attitudes and intention regarding anxiety-related alcohol use among Black hazardous drinkers with clinical anxiety. Type: Interventional Start Date: May 2023 |
Evaluation of Family-Based Behavioral Treatments for Youth With Anxiety and Obsessive-Compulsive Disorder
Baylor College of Medicine
Obsessive-Compulsive Disorder in Children
Anxiety Disorder of Childhood
Social Anxiety Disorder of Childhood
Obsessive-Compulsive Disorder in Adolescence
Generalized Anxiety Disorder
Anxiety and obsessive-compulsive disorders are among the most common in children.
Although cognitive behavioral therapy (CBT) is an effective and evidence-based treatment
for such disorders, access to CBT is often limited. Family-based and internet-delivered
therapy is one method to increase access... expand
Anxiety and obsessive-compulsive disorders are among the most common in children. Although cognitive behavioral therapy (CBT) is an effective and evidence-based treatment for such disorders, access to CBT is often limited. Family-based and internet-delivered therapy is one method to increase access to care. The purpose of this project is to evaluate the comparative efficacy and treatment mechanisms of two lower-intensity but effective treatments for families of children with anxiety or obsessive compulsive disorder (OCD) via telehealth compared to an adapted Relaxation and Mentorship Training (RMT) intervention involving breathing exercises with a therapist. Type: Interventional Start Date: Sep 2023 |
Neurostimulation Versus Therapy for Problems With Emotions
Duke University
Emotion Regulation
Mood Disorders
Stress Disorder
Anxiety Disorders
OCD
The primary goal of this clinical trial is to evaluate the unique neural and behavioral
effects of a one-session training combining emotion regulation skills training, with
excitatory repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral
prefrontal cortex (dlPFC). The secondary... expand
The primary goal of this clinical trial is to evaluate the unique neural and behavioral effects of a one-session training combining emotion regulation skills training, with excitatory repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (dlPFC). The secondary aim is to identify key changes in the emotion regulation neural network following the combined intervention versus each of the components alone. The third aim is to explore personalized biomarkers for response to emotion regulation training. Participants will undergo brain imaging while engaging in an emotional regulation task. Participants will be randomly assigned to learn one of two emotion regulation skills. Participants will be reminded of recent stressors and will undergo different types of neurostimulation, targeted using fMRI (functional MRI) results. Participants who may practice their emotion regulation skills during neurostimulation in a one-time session. Following this training, participants will undergo another fMRI and an exit interview to assess for immediate neural and behavioral changes. Measures of emotion regulation will be assessed at a one week and a one month follow up visit. Type: Interventional Start Date: May 2023 |
Adjunctive Allogeneic Mesenchymal Stem Cells for Treatment-resistant Bipolar Depression
The University of Texas Health Science Center, Houston
Treatment-resistant Bipolar Depression
The overall objective of the investigators is to assess the therapeutic efficacy and
tolerability of Allogeneic Bone Marrow Derived Multipotent Mesenchymal Stromal Cells
(MSCs) isolated from hematogenous bone marrow for treatment of treatment-resistant
bipolar depression patient (TRBD). expand
The overall objective of the investigators is to assess the therapeutic efficacy and tolerability of Allogeneic Bone Marrow Derived Multipotent Mesenchymal Stromal Cells (MSCs) isolated from hematogenous bone marrow for treatment of treatment-resistant bipolar depression patient (TRBD). Type: Interventional Start Date: Apr 2022 |
Using Neurostimulation to Accelerate Change in Misophonia: a Pilot Study
Duke University
Misophonia
Emotion Dysregulation
Sensory Processing Disorder
Auditory Over Responsivity
Anxiety Disorder
Misophonia, the inability to tolerate certain repetitive distressing sounds that are
common, is gaining, recognition as an impairing condition. It is not a well-understood
condition and there are no known treatments. The purpose of this study is to test a new
misophonia intervention that uses emotion... expand
Misophonia, the inability to tolerate certain repetitive distressing sounds that are common, is gaining, recognition as an impairing condition. It is not a well-understood condition and there are no known treatments. The purpose of this study is to test a new misophonia intervention that uses emotion regulation strategies and different types of brain stimulation on misophonic distress. This study will examine changes in brain activity during presentation and regulation of misophonic versus distressing sounds. The study team plans to alter activity in a key area of the brain responsible for emotion regulation circuitry over 4 sessions with the goal to test if this intervention helps misophonic distress. Sixty adult participants with moderate to severe misophonia will be recruited and taught an emotion regulation skill and randomly assigned to receive one of two types of repetitive transcranial magnetic stimulation (rTMS). The study includes 9-10 visits: the remote screening visit(s), the initial MRI, the four neurostimulation sessions, the follow-up MRI, and two additional remote 1- and 3-month follow-up visits. Type: Interventional Start Date: May 2024 |
8 Week Multi-site Study of MYDAYIS® for Bipolar Depression
Mayo Clinic
Bipolar Depression
This protocol is a Phase 2 multi-site study which aims to evaluate the safety and
effectiveness of MYDAYIS® as adjunctive therapy for adults with bipolar depression.
Results from this study WILL NOT be used to contribute to an approval of MYDAYIS ®
for this indication. expand
This protocol is a Phase 2 multi-site study which aims to evaluate the safety and effectiveness of MYDAYIS® as adjunctive therapy for adults with bipolar depression. Results from this study WILL NOT be used to contribute to an approval of MYDAYIS ® for this indication. Type: Interventional Start Date: Jul 2020 |
CAMPUS Expanded "Classification and Assessment of Mental Health Performance Using Semantics Expanded"
Clarigent Health
Suicide
Suicidal
Suicide, Attempted
Suicidal Ideation
Depression
Open enrollment study to collect data for the optimization of machine learning models for
use in an app for the early detection of mental health and suicidal risk. expand
Open enrollment study to collect data for the optimization of machine learning models for use in an app for the early detection of mental health and suicidal risk. Type: Observational Start Date: Jun 2020 |
Promoting Resilience in Stroke Survivor-carepartner Dyads (ReStoreD)
University of Utah
Stroke
Depression, Anxiety
Coping Skills
Couples
Affecting nearly 800,000 people in the US every year, stroke is a leading cause of
long-term disability, and has serious consequences for stroke survivors and their
carepartners. Our project uses a scientifically rigorous efficacy study to evaluate a
remotely delivered 8-week dyadic (couples-based)... expand
Affecting nearly 800,000 people in the US every year, stroke is a leading cause of long-term disability, and has serious consequences for stroke survivors and their carepartners. Our project uses a scientifically rigorous efficacy study to evaluate a remotely delivered 8-week dyadic (couples-based) positive psychology intervention to reduce emotional distress in stroke survivors and their carepartners. If successful, couples may be better emotionally equipped to cope with the sequelae of stroke, and have better rehabilitation outcomes and quality of life. Type: Interventional Start Date: Jul 2022 |
Latino Teen Depression Treatment Study
Duke University
Depression
Despite experiencing higher rates of depressive symptoms (Center for Disease Control and
Prevention, 2020) and similar rates of Major Depressive Disorder (MDD; Substance Abuse
and Mental Health Services Administration (SAMHSA), 2019), Latino adolescents in the U.S.
are significantly less likely than... expand
Despite experiencing higher rates of depressive symptoms (Center for Disease Control and Prevention, 2020) and similar rates of Major Depressive Disorder (MDD; Substance Abuse and Mental Health Services Administration (SAMHSA), 2019), Latino adolescents in the U.S. are significantly less likely than their non-Latino White peers to receive treatment for MDD (SAMHSA, 2019). The purpose of this study is to identify a stakeholder-preferred implementation strategy that may improve psychotherapy attendance among Latino adolescents. Latino adolescent-parent dyads and healthcare providers will be recruited from healthcare settings and social media. Focus groups will be conducted with healthcare providers (n=5), and individual interviews will be conducted with Latino adolescents with a diagnosis of depression (n=15) and their parents (n=15). Type: Observational Start Date: Oct 2022 |
Initial Assessment of the Feasibility and Efficacy of a Scalable Digital CBT for Generalized Anxiety...
Boston University Charles River Campus
Anxiety Disorders
Cardiovascular Diseases
Anxiety
Health Behavior
The treatment of generalized anxiety disorder (GAD) in an accessible manner represents an
unmet need for those with cardiovascular disease (CVD), given that patients with CVD
experience numerous barriers for in-person treatment engagement. The research plan for
the proposed pilot project will entail:... expand
The treatment of generalized anxiety disorder (GAD) in an accessible manner represents an unmet need for those with cardiovascular disease (CVD), given that patients with CVD experience numerous barriers for in-person treatment engagement. The research plan for the proposed pilot project will entail: (1) open study of the acceptability of the digital intervention (N=5), followed by (2) recruitment and randomization of 90 individuals with a history of acute CVD events and clinical levels of GAD symptoms to dCBT or a waitlist (Control) condition, using a 1.5:1 allocation (dCBT:Control). Type: Interventional Start Date: Feb 2022 |
Ovarian Hormone Withdrawal, Anhedonia, and Reward Sensitivity in Women With Premenstrual Exacerbations...
University of North Carolina, Chapel Hill
Major Depressive Disorder
The goal of this clinical trial is to learn how hormonal changes over the menstrual cycle
affect mood symptoms in reproductive-aged women with depression that worsens during the
premenstrual period. The main questions it aims to answer are:
--How do fluctuations in estradiol and progesterone across... expand
The goal of this clinical trial is to learn how hormonal changes over the menstrual cycle affect mood symptoms in reproductive-aged women with depression that worsens during the premenstrual period. The main questions it aims to answer are: --How do fluctuations in estradiol and progesterone across the menstrual cycle affect the ability to experience pleasure and the neural sensitivity to reward in hormone-sensitive, depressed women? And consequently, how does stabilizing the luteal phase decline in estrogen and progesterone (using estradiol patches and progesterone pills) affect these changes? Participants will: - Receive hormones followed by placebo, or vice versa, for a total of four weeks across three menstrual cycles - Complete daily mood ratings - Collect home urine samples for hormone testing - Complete five biobehavioral testing sessions during which neural responses are recorded (via electroencephalography, or EEG) during an acute stress task and computer tasks Type: Interventional Start Date: Sep 2024 |
Community Park-Based Programs for Health Promotion: the Fit2Lead Prospective Cohort Study
Duke University
Anxiety
Wellness, Psychological
Overweight or Obesity
Hypertension
Prehypertension
The Fit2Lead prospective cohort study examines the effects of a park-based youth mental
health and resilience afterschool program on youth participant mental health, resilience,
physical fitness, and violence prevention outcomes. Duke will perform a secondary
analysis of the data collected as part... expand
The Fit2Lead prospective cohort study examines the effects of a park-based youth mental health and resilience afterschool program on youth participant mental health, resilience, physical fitness, and violence prevention outcomes. Duke will perform a secondary analysis of the data collected as part of the Fit2Lead prospective cohort study run by Miami-Dade County Parks and Recreation. Type: Observational Start Date: Feb 2016 |
Ketamine-Assisted Psychotherapy (KAP) Compared to Ketamine Alone for the Treatment of Depression
Icahn School of Medicine at Mount Sinai
Major Depressive Disorder
The proposed study is a single-site, randomized, controlled clinical trial (RCT)
comparing ketamine-assisted psychotherapy (KAP) to a standard evidence-based regimen of
ketamine administered in a medical model without psychotherapy (KET). Eligible study
participants will be adults with major depressive... expand
The proposed study is a single-site, randomized, controlled clinical trial (RCT) comparing ketamine-assisted psychotherapy (KAP) to a standard evidence-based regimen of ketamine administered in a medical model without psychotherapy (KET). Eligible study participants will be adults with major depressive disorder (MDD). Adults with MDD will be randomized to KAP or KET in a 1:1 allocation. Each treatment group will receive KAP or KET over a period of four weeks. Measurement of depression severity, wellness, neurocognitive functioning and other parameters will occur at baseline prior to treatment, immediately following the end of the acute treatment period, and over an 8-week (two month) treatment follow-up period. Type: Interventional Start Date: Oct 2024 |
Equity Using Interventions for Pain and Depression
Indiana University
Chronic Pain
Musculoskeletal Pain
Depression
Health Equity
This project is part of the NIH Helping to End Addiction Long-term (HEAL) initiative
(https://heal.nih.gov/). This pilot randomized controlled trial (RCT) is phase 2 of a
two-phase, 5-year project with the overarching goal of testing a decision aid
(DA)/coaching intervention, tailored to Black patients... expand
This project is part of the NIH Helping to End Addiction Long-term (HEAL) initiative (https://heal.nih.gov/). This pilot randomized controlled trial (RCT) is phase 2 of a two-phase, 5-year project with the overarching goal of testing a decision aid (DA)/coaching intervention, tailored to Black patients with comorbid chronic pain and depression, to encourage use of and adherence to nonpharmacological pain treatments (NPTs). This 2-arm pilot trial will aim to enroll up to 355 Black patients with comorbid chronic musculoskeletal pain and depression in primary care from an urban safety-net health system (Eskenazi) in order to randomize at least 304 patients. After the baseline assessment, patients randomized to the intervention will be asked to participate in 4 coaching sessions over approximately 12 weeks. Sessions will use Motivational Interviewing principles to foster openness to NPTs and self-efficacy by helping patients identify their goals and priorities, understand their NPT options, prepare them to discuss and choose options with their primary care providers (PCPs), and reinforce these choices to foster maintenance of these changes. DA contents will be integrated into these sessions, which will facilitate discussion of these options with their PCP. The first 3 sessions take place prior to the patient's next scheduled PCP visit; the final session occurs after this visit. Assessments will be conducted at baseline, 3 months (i.e., after completing the final coaching session), and 6 months. Patients randomized to the wait-list control group will receive usual care (in addition to study assessments at baseline, 3 months, and 6 months). After completing the final assessment, they will then be given the DA and offered a 20-minute coaching session to walk them through it. Type: Interventional Start Date: Aug 2024 |
Study of ITI-1284 as an Adjunctive Treatment in Patients With Generalized Anxiety Disorder
Intra-Cellular Therapies, Inc.
Generalized Anxiety Disorder
This is a multicenter, randomized, double-blind, placebo-controlled study evaluating the
efficacy, safety, and tolerability of ITI-1284 compared with placebo as adjunctive
therapy to GAD treatment in patients meeting Diagnostic and Statistical Manual of Mental
Disorders, Fifth Edition, Text Revision... expand
This is a multicenter, randomized, double-blind, placebo-controlled study evaluating the efficacy, safety, and tolerability of ITI-1284 compared with placebo as adjunctive therapy to GAD treatment in patients meeting Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR) criteria for GAD who have an inadequate response to ongoing GAD treatment. Type: Interventional Start Date: Aug 2024 |
A Comparative Effectiveness Study of PTSD Treatments Among Sexual and Gender Minority Populations
University of California, San Francisco
PTSD
The goal of this clinical trial is see if Cognitive Processing Therapy and STAIR
Narrative Therapy work to treat posttraumatic stress disorder (PTSD) among lesbian, gay,
bisexual, transgender, queer/questioning, intersex, asexual/aromantic, and all other
sexual or gender minority (LGBTQIA+) adults.... expand
The goal of this clinical trial is see if Cognitive Processing Therapy and STAIR Narrative Therapy work to treat posttraumatic stress disorder (PTSD) among lesbian, gay, bisexual, transgender, queer/questioning, intersex, asexual/aromantic, and all other sexual or gender minority (LGBTQIA+) adults. The main questions it aims to answer are: - Do these treatments reduce PTSD symptoms in LGBTQIA+ patients? - Do these treatments help improve quality of life and reduce depression in LGBTQIA+ patients? - Do stress from stigma and discrimination and drug/alcohol use change the impact of the treatment on PTSD symptoms? - Are LGBTQIA+ patients satisfied with these treatments? Do these treatments work differently among different groups within the LGBTQIA+ community? - Do LGBTQIA+ patients complete these treatments? Study participants will receive one of these two PTSD treatments. Participants will complete assessments before and after receiving treatment. Type: Interventional Start Date: Aug 2024 |
Psychiatric Outcomes of Unruptured Intracranial Aneurysms (POUIA)
Montefiore Medical Center
Anxiety Depression
Aneurysm Cerebral
Mental Health Wellness 1
The impact of cerebrovascular procedures on patients experiencing anxiety and depression
is not well studied despite the high prevalence of these mental health disorders.
Unruptured Intracranial aneurysms (UIAs) have a prevalence of approximately 3% and an
annual risk of 1-2% in the general population.... expand
The impact of cerebrovascular procedures on patients experiencing anxiety and depression is not well studied despite the high prevalence of these mental health disorders. Unruptured Intracranial aneurysms (UIAs) have a prevalence of approximately 3% and an annual risk of 1-2% in the general population. Despite the high risk of fatality following aneurysm rupture with a rate of 40-50%, the overall aneurysm growth and rupture risks are rare (less than 3% per aneurysm per year) and many patients can be observed with serial follow-up imaging over years. Nevertheless, due to the gravity of the bad consequences of aneurysm rupture, simply informing many patients of UIA diagnosis has been found to result in worse outcomes of health-related quality of life. This study aims to investigate the impact of awareness of untreated UIA on the patients' mental health utilizing the Hospital Anxiety and Depression Scale (HADS) tool. Type: Observational Start Date: Dec 2023 |
RESISTance Exercise for Depression Trial
Iowa State University
Major Depressive Disorder
Depression is a leading cause of disability worldwide and current treatments are
ineffective for many people. This trial will investigate the efficacy of a 16-week high
vs low dose resistance exercise training program for the treatment of Major Depressive
Disorder (MDD) in 200 adults. expand
Depression is a leading cause of disability worldwide and current treatments are ineffective for many people. This trial will investigate the efficacy of a 16-week high vs low dose resistance exercise training program for the treatment of Major Depressive Disorder (MDD) in 200 adults. Type: Interventional Start Date: Jan 2024 |
Single-dose Ketamine Treatment to Improve Depression in Mild Cognitive Impairment
Icahn School of Medicine at Mount Sinai
Depression
Mild Cognitive Impairment
Ketamine is a NMDA-receptor antagonist that promotes synapse formation and has been shown
to rapidly improve symptoms in depression. Even a single dose of ketamine has been shown
to improve depression and cognition with short-term memory, inhibitory control, cognitive
flexibility, and processing speed... expand
Ketamine is a NMDA-receptor antagonist that promotes synapse formation and has been shown to rapidly improve symptoms in depression. Even a single dose of ketamine has been shown to improve depression and cognition with short-term memory, inhibitory control, cognitive flexibility, and processing speed showing improvements within days of treatment. The mechanism behind ketamine's rapid action is not clear but some groups have speculated it may be related to enhanced neuroplasticity, particularly in the frontal areas and the hippocampus. If this mechanism is accurate, ketamine may be especially effective in treating mild cognitive impairment and depression (MCI-D) where changes in the hippocampus and frontal areas have been implicated. Although few studies have been published on the effects of ketamine in older adults, some small pilot studies suggest that ketamine treatment might be effective in improving depression in older adults and relatively safe. There are no studies looking at the effects of ketamine treatment in patients with MCI-D. The research team hypothesize that IV ketamine treatment will be well-tolerated and will improve depression and cognition in patients with MCI-D. The study team will explore the effects of brain imaging abnormalities and amyloid biomarker status on the responsiveness to ketamine. The study team will conduct an open-label pilot study designed to gather data to support an application for a larger NIH-funded study. Type: Interventional Start Date: Nov 2024 |
Study to Assess the Effects of Oral NMRA-335140 in Participants With Major Depressive Disorder
Neumora Therapeutics, Inc.
Major Depressive Disorder
This randomized, double-blind, placebo-controlled, multicenter study will evaluate the
effects of NMRA-335140 (formerly BTRX-335140) on symptoms of depression in participants
with Major Depressive Disorder (MDD). The study design consists of a Screening Period (up
to 35 days), and a 6-week Treatment... expand
This randomized, double-blind, placebo-controlled, multicenter study will evaluate the effects of NMRA-335140 (formerly BTRX-335140) on symptoms of depression in participants with Major Depressive Disorder (MDD). The study design consists of a Screening Period (up to 35 days), and a 6-week Treatment Period (during which participants will receive either NMRA-335140 or placebo). At the completion of the 6-week Treatment Period, participants who complete the study, provide informed consent, and meet the eligibility criteria may enter an open-label extension study (NMRA-335140-501). Type: Interventional Start Date: Dec 2023 |
Study to Assess the Effects of Oral NMRA-335140 Versus Placebo in Participants With Major Depressive...
Neumora Therapeutics, Inc.
Major Depressive Disorder
This is a randomized, double-blind, placebo-controlled, multicenter study to evaluate the
effects of NMRA-335140 (formerly BTRX-335140) on symptoms of depression in participants
with Major Depressive Disorder (MDD). The study design consists of a Screening Period (up
to 28 days), and a 6-week Treatment... expand
This is a randomized, double-blind, placebo-controlled, multicenter study to evaluate the effects of NMRA-335140 (formerly BTRX-335140) on symptoms of depression in participants with Major Depressive Disorder (MDD). The study design consists of a Screening Period (up to 28 days), and a 6-week Treatment Period (during which participants will receive either NMRA-335140 or placebo). At the completion of the 6-week Treatment Period, participants who complete the study, provide informed consent, and meet the eligibility criteria may enter an open-label extension study (NMRA-335140-501). Type: Interventional Start Date: Dec 2023 |
A Study of a N, N-dimethyltryptamine (DMT) Analog (CYB004) in Participants With Generalized Anxiety Disorder...
Cybin IRL Limited
Generalized Anxiety Disorder
The purpose of this proof-of-concept trial is to examine the safety, tolerability, and
pharmacokinetics (PK), and preliminary clinical efficacy of CYB004 participants with GAD. expand
The purpose of this proof-of-concept trial is to examine the safety, tolerability, and pharmacokinetics (PK), and preliminary clinical efficacy of CYB004 participants with GAD. Type: Interventional Start Date: May 2024 |
Prenatal Yoga to Prevent Postpartum Depression
Henry Ford Health System
Postpartum Depression
Although psychological interventions exist for the prevention of PPD, a yoga-based
intervention to prevent PPD among at-risk women utilizes a similar theoretical foundation
(i.e., mindfulness), may be more acceptable to women of minority status, and may confer
additional physical activity benefits.... expand
Although psychological interventions exist for the prevention of PPD, a yoga-based intervention to prevent PPD among at-risk women utilizes a similar theoretical foundation (i.e., mindfulness), may be more acceptable to women of minority status, and may confer additional physical activity benefits. The purpose of this pilot study is to determine the effectiveness of using a virtually delivered prenatal yoga intervention for the prevention of PPD among at-risk women in a diverse health care system and explore preliminary factors which influence implementation of the intervention. This study has 2 phases: Phase 1 will evaluate facilitators and barriers to intervention implementation among patient, clinician, and health system stakeholders, followed by an open trial, and Phase 2 will include conducting an 8-session pilot randomized controlled trial to assess the feasibility and acceptability of the proposed prenatal yoga intervention among women with a history of depression, as well as the onset and course of PPD and mediating factors. The specific aims are to: 1) Optimize delivery of a yoga intervention within a healthcare system to prevent PPD through examining facilitators and barriers of implementation, 2) Examine feasibility, acceptability and satisfaction of the intervention within a health care system, and 3) Evaluate preliminary effectiveness of the intervention on PPD and proposed mechanisms. For Phase 1, separate focus groups with patient stakeholders and clinician and administrative stakeholders will inform intervention implementation, and an open trial to refine and optimize the intervention. For Phase 2, women with a history of depression who are 8-28 weeks pregnant will be randomized to the intervention group (n=24) or treatment-as-usual (n=24) and will complete survey measures at baseline, post-intervention, and 1 and 3 months postpartum. It is hypothesized that the intervention will be feasible and acceptable, engage women of racial/ethnic minority status, and contribute to lower rates of PPD onset. Embodiment and mindfulness are the proposed mediators. Knowledge gained from this study can support prevention efforts for PPD and improve the adverse public health impact of this disorder. Type: Interventional Start Date: Oct 2024 |
REmotely-delivered Supportive Programs for Improving Surgical Pain and disTrEss
Wake Forest University Health Sciences
Postoperative Pain, Acute
Postoperative Depression
Anxiety
Sleep Disturbance
Malignant Female Reproductive System Neoplasm
The purpose of this research study is to learn how two different supportive programs may
help women feel better after surgery. This study will measure if one type of supportive
program is more useful than the other for improving wellbeing after surgery. expand
The purpose of this research study is to learn how two different supportive programs may help women feel better after surgery. This study will measure if one type of supportive program is more useful than the other for improving wellbeing after surgery. Type: Interventional Start Date: Jun 2023 |
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