Search Clinical Trials
Before medications are approved by the U.S. Food and Drug Administration (FDA) or before certain therapy methods are widely accepted as effective, they are tested on people who volunteer to participate in a clinical trial.
Organizations across the country are looking for people like you to take part in their research studies. The list of studies below have been selected from ClinicalTrials.gov based on their inclusion of one or more of the following terms: anxiety disorders, depression, OCD, PTSD, and bipolar disorder.
The Anxiety and Depression Association of America (ADAA) is supportive of research that is conducted through clinical trials. Participating in research can potentially help change the mental health outcomes for you and others who suffer anxiety, depression, and related disorders. You may learn about new interventions/treatments that are being considered.
Read this ADAA blog about things to know and questions to ask before committing to a clinical trial.
This website page is brought to you in partnership with ResearchMatch.
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Methylphenidate for Ptsd and Stroke Veterans
VA Office of Research and Development
PTSD
Stroke
Veterans with post-traumatic stress disorder (PTSD) have an increased risk of developing
ischemic stroke. Veterans enduring PTSD face difficulties in managing their PTSD severity
after suffering from a stroke. Currently, clinical trials in PTSD exclude patients with
stroke and patients with significant... expand
Veterans with post-traumatic stress disorder (PTSD) have an increased risk of developing ischemic stroke. Veterans enduring PTSD face difficulties in managing their PTSD severity after suffering from a stroke. Currently, clinical trials in PTSD exclude patients with stroke and patients with significant premorbid psychological conditions like PTSD are usually excluded from stroke clinical trials. Methylphenidate (MPH) is a central nervous system stimulant that can improve PTSD symptoms: avoidance behaviors, social withdrawal, hyperarousal, and working memory. MPH can also improve post-stroke outcomes: mood, activities of daily living, and motor functioning. In clinical trials for PTSD or stroke, MPH has been shown to be well-tolerated with minimal adverse events. The high prevalence of PTSD in Veterans with stroke provides strong justification for development of interventions that effectively and simultaneously target both conditions. The overarching goal of our proposal is to understand how MPH improves PTSD severity in Veterans with comorbid stroke. Type: Interventional Start Date: Jan 2022 |
Managing Anxiety in Pediatric Primary Care (MAPP)
UConn Health
Anxiety
Anxiety Disorders
The goal of this clinical trial is to conduct a randomized controlled trial to enhance
the capacity of pediatric primary care providers to assist their patients who struggle
with anxiety.
The study aims to refine and assess the feasibility of the Anxiety Action Plan (AxAP), a
brief intervention... expand
The goal of this clinical trial is to conduct a randomized controlled trial to enhance the capacity of pediatric primary care providers to assist their patients who struggle with anxiety. The study aims to refine and assess the feasibility of the Anxiety Action Plan (AxAP), a brief intervention to reduce pediatric anxiety, delivered by primary care providers (PCPs) in community pediatric primary care clinics. The goal of the AxAP is to enhance the capacity of PCPs to identify and intervene with anxious youth, which will enhance access to care in general and especially in locations with few mental health specialists. PCPs participating in this study will attend a training, administer the intervention to enrolled youth assigned to the MAPP condition, participate in coaching sessions, and fill out study questionnaires. Families participating in this study will complete evaluations with the study team, receive the intervention from their PCP (if assigned to the MAPP condition), and fill out study questionnaires. Researchers will compare the MAPP intervention to Enhanced Usual Care (EUC; consisting of videos, handouts, and other resources for anxiety reduction) to see the differences, if any, in child outcomes. Type: Interventional Start Date: Nov 2023 |
MBCT Intervention: Healthy Mind, Healthy Living
University of Washington
Mindfulness Based Cognitive Therapy
Depression
Sleep
Anxiety Depression
Depression among older Korean Americans are rising. Mindfulness-based cognitive therapy
(MBCT) is an evidence-based intervention (EBI), effective for preventing depression
relapse and reducing depressive symptoms. To enhance feasibility, acceptability, and
reach, a brief version of MBCT has been developed... expand
Depression among older Korean Americans are rising. Mindfulness-based cognitive therapy (MBCT) is an evidence-based intervention (EBI), effective for preventing depression relapse and reducing depressive symptoms. To enhance feasibility, acceptability, and reach, a brief version of MBCT has been developed and delivered by telephone (brief MBCT-T), but has only been tested in primarily White samples. This study will test test the effect of brief MBCT-T among older Korean Americans. Type: Interventional Start Date: Apr 2023 |
Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy
Washington University School of Medicine
Treatment Resistant Depression
Electroconvulsive therapy (ECT) alleviates treatment-resistant depression (TRD) through
repeated generalized seizures. The goal of this study is to evaluate how ECT impacts
sleep-wake regulation and efficiency of information transfer in functional networks in
different states of arousal. expand
Electroconvulsive therapy (ECT) alleviates treatment-resistant depression (TRD) through repeated generalized seizures. The goal of this study is to evaluate how ECT impacts sleep-wake regulation and efficiency of information transfer in functional networks in different states of arousal. Type: Observational Start Date: Mar 2023 |
Brief Interventions for Coping With Distress
Teachers College, Columbia University
Distress, Emotional
Emotional Dysfunction
Anxiety
Depression
This study is being done to compare the effectiveness of three different skills trainings
to cope with distress. These three trainings are: 1) an attention skills training, 2) an
attention and reflective thought skills training, and 3) a health and wellness education
training. expand
This study is being done to compare the effectiveness of three different skills trainings to cope with distress. These three trainings are: 1) an attention skills training, 2) an attention and reflective thought skills training, and 3) a health and wellness education training. Type: Interventional Start Date: May 2023 |
Compassion Meditation vs. Health Education for Veterans
VA Office of Research and Development
Chronic Pain
Stress Disorders, Posttraumatic
Depression
Chronic pain (CP) is a major health problem for military Veterans, and CP is often
associated with comorbid mental health problems, including posttraumatic stress disorder
(PTSD) and depression. CP with psychological comorbidity is associated with increased
healthcare costs, medication use, risk of... expand
Chronic pain (CP) is a major health problem for military Veterans, and CP is often associated with comorbid mental health problems, including posttraumatic stress disorder (PTSD) and depression. CP with psychological comorbidity is associated with increased healthcare costs, medication use, risk of suicide and rates of disability and reduced quality of life. Current empirically supported treatments do not always lead to substantial improvements (up to 50% of patients drop out or are do not respond to treatment). This project was designed to evaluate the efficacy of a novel intervention for addressing these challenges. Compassion meditation (CM), a meditative practice that focuses on the wish to remove suffering, is a contemplative practice that has promise for the amelioration of physical and mental health problems as well as promoting positive affect and improving quality of life. This study will evaluate the efficacy of Cognitively-Based Compassion Training for Chronic Pain with Psychological Comorbidity (CBCT-CP+) compared to Health Education while Living with Pain (H.E.L.P.) control condition, in a sample of among Veterans with CP conditions and psychological comorbidity. Type: Interventional Start Date: Jan 2022 |
Wraparound for High-risk Families With Substance Use Disorders: Examining Family, Child, and Parent Outcomes
Dartmouth-Hitchcock Medical Center
Substance-Related Disorders
Depression
Stress Disorders, Post-Traumatic
Child Abuse
Child Neglect
The investigators propose a Hybrid Type 1 effectiveness-implementation quasi-experimental
trial. Participants are drawn from two different communities contemporaneously. The
intervention participants in one community receive a Wraparound intervention. Comparison
group participants drawn from a second... expand
The investigators propose a Hybrid Type 1 effectiveness-implementation quasi-experimental trial. Participants are drawn from two different communities contemporaneously. The intervention participants in one community receive a Wraparound intervention. Comparison group participants drawn from a second matched community receive treatment as usual. With this design, the investigators aim to study outcomes associated with the intervention as well as explore important facilitators and barriers associated with the implementation and other factors associated with reach / participation, engagement and acceptability. Wraparound is a structured 12-month family-driven "process" that is guided by family goals, includes a team of supports to wrap around families, and coordinates care for families. Wraparound has been primarily delivered and tested with families of older-age children with severe emotional and behavioral needs in an attempt to prevent residential placement. The investigators are interested in testing the model in a sample of families (n=160) affected by substance use disorders who have children placed outside the home or are at risk of such placement. The investigators hypothesize that families receiving Wraparound will obtain better parenting and family functioning outcomes (primary outcome); child safety, permanency, and well-being; and parental recovery than families receiving treatment as usual. The investigators will also explore factors associated with higher levels of engagement and outcomes, including family characteristics, referral sources and hand-off, and similarly, explore barriers and facilitators associated with engagement and/or outcomes. Type: Interventional Start Date: Nov 2020 |
Poststroke Depression in Hemorrhagic Stroke
University of Washington
Stroke Hemorrhagic
Depression
A double-blinded placebo-controlled randomized trial to evaluate the effect of
preventative treatment of depression in survivors of aneurysmal subarachnoid hemorrhage
(aSAH), a type of stroke. expand
A double-blinded placebo-controlled randomized trial to evaluate the effect of preventative treatment of depression in survivors of aneurysmal subarachnoid hemorrhage (aSAH), a type of stroke. Type: Interventional Start Date: Mar 2019 |
Promoting Resilience in Early Survivorship Among Adolescents and Young Adults With Cancer
Dana-Farber Cancer Institute
Stress
Anxiety
The goal of this study is to find the best way to help participants and families manage
the stress of facing a serious illness and be better able to "bounce back" or be
resilient after a difficult situation. Participants will take part in the "Promoting
Resilience in Stress Management" PRISM program,... expand
The goal of this study is to find the best way to help participants and families manage the stress of facing a serious illness and be better able to "bounce back" or be resilient after a difficult situation. Participants will take part in the "Promoting Resilience in Stress Management" PRISM program, which is designed to provide skills to change or improve the impact of stress in everyday life. The name of the intervention used in this research study is: -PRISM (a mobile app program comprised of 6 sessions of skills-based, manualized resilience education) Type: Interventional Start Date: Oct 2023 |
SMART Trial to Predict Anhedonia Response to Antidepressant Treatment
Mclean Hospital
Major Depressive Disorder
The main goal of this research is to use behavioral, brain, and clinical data to
determine which type of antidepressant might be optimal before people with depression
start treatment. expand
The main goal of this research is to use behavioral, brain, and clinical data to determine which type of antidepressant might be optimal before people with depression start treatment. Type: Interventional Start Date: Sep 2022 |
The RAFT ECT Study
The George Institute
Major Depressive Episode
Severe depression is devastating for those affected and is often associated with
significant risk of suicide. Electroconvulsive therapy (ECT) is a highly effective acute
treatment for severe depression, but its use and acceptability are limited by cognitive
side effects. Of these, retrograde memory... expand
Severe depression is devastating for those affected and is often associated with significant risk of suicide. Electroconvulsive therapy (ECT) is a highly effective acute treatment for severe depression, but its use and acceptability are limited by cognitive side effects. Of these, retrograde memory loss is most concerning, and can be long-term. The introduction of ultrabrief right unilateral (UBRUL) ECT into clinical practice has been an important step in reducing the risk of memory impairment, but significant deficits still occur. A new form of UBRUL ECT which utilises a Frontoparietal electrode placement represents a further development. Preliminary data suggest that Frontoparietal UBRUL has good efficacy and less cognitive side effects than UBRUL given using the conventional Temporoparietal electrode placement. Designed as a pivotal trial, this protocol will be the first RCT comparing these two forms of ECT, producing the rigorous efficacy and safety data required to change clinical practice/policy. This is a multicentre, parallel group RCT with 1:1 allocation ratio between Frontoparietal (intervention) and Temporoparietal (comparator) forms of UBRUL ECT. Participation will involve receiving randomised acute ECT under blinded conditions during the randomised acute treatment period (typically around 4 weeks), then completion of a 24-week follow-up period which commences after the cessation of all acute ECT. The study protocol aims to provide 12 randomised acute ECT treatments, though the number of treatments (and hence the length of the randomised acute treatment period) can be adjusted by the participant's own treating/admitting psychiatrist according to their clinical judgement. Type: Interventional Start Date: Mar 2023 |
Brain Stimulation for Severe Depression
Inner Cosmos Inc
Depression Severe
Chronic intracalvarial cortical stimulation is a minimally invasive method involving the
neurosurgical placement of an electrode above the inner table of the skull. Over time,
intracalvarial cortical stimulation is intermittently activated to modulate locally and
distally connected brain regions.... expand
Chronic intracalvarial cortical stimulation is a minimally invasive method involving the neurosurgical placement of an electrode above the inner table of the skull. Over time, intracalvarial cortical stimulation is intermittently activated to modulate locally and distally connected brain regions. Because of the important role played by the dorsolateral prefrontal cortex in mood regulation, the goal of this study is to apply intracalvarial prefrontal cortical stimulation (IpCS) over the dorsolateral prefrontal cortex in severely treatment-resistant depressed (TRD) patients. Per the DSM-V and Centre for Medicare and Medicaid Services (CMS) nomenclatures, TRD patients are commonly defined as those whose treatment failed to produce response or remission after 2 or more attempts of sufficient duration and treatment dose. In the investigator's study, eligible TRD subjects will have a diagnosis of major depressive disorder with a suboptimal response to an adequate dose and duration of at least two different antidepressant treatment categories. These subjects will also have had exposure and transiently (non-durably) responded to non-invasive neurostimulation. The investigator anticipates that severely Treatment Resistant Depressed (TRD) Subjects with IpCS of the dorsolateral prefrontal cortex will show a significant decrease in depression symptoms as measured by the Montgomery-Asberg Depression Rating Scale (MADRS) at four months post-implant when compared to baseline. The investigator will enroll up to 20 subjects with severe refractory depression in an open trial, followed for up to one year. Depressive and cognitive symptoms will be rated periodically to assess the safety and efficacy of this procedure. Type: Interventional Start Date: Jul 2022 |
Neuromodulation for Enhancement of Emotion Regulation in Bipolar Mood Disorders
Massachusetts General Hospital
Bipolar Disorder
The investigators are conducting this research study to better understand how individuals
with bipolar disorder regulate their emotions, and if transcranial magnetic stimulation
(TMS) can help improve emotion regulation for individuals with bipolar mood disorders. expand
The investigators are conducting this research study to better understand how individuals with bipolar disorder regulate their emotions, and if transcranial magnetic stimulation (TMS) can help improve emotion regulation for individuals with bipolar mood disorders. Type: Interventional Start Date: Mar 2021 |
Brain Stimulation and Decision-making
Emory University
Depression
Decision-making is an important process that is frequently shown to be impaired in
patients with depression. While a number of preclinical and clinical studies have
identified key regions involved in this process, it remains unclear exactly how these
regions are influencing choice behavior especially... expand
Decision-making is an important process that is frequently shown to be impaired in patients with depression. While a number of preclinical and clinical studies have identified key regions involved in this process, it remains unclear exactly how these regions are influencing choice behavior especially when choices become more challenging. The goal of this project is to understand how these regions, such as the cingulate cortex, impact difficult choice behavior. Specifically, the researchers are interested in learning how disruptions in cognitive control might impact choice preferences during difficult decisions in depressed patients. To do this, this study will recruit participants with depression (as well as healthy controls) to perform game-like tasks in the laboratory while undergoing TMS or TI. Type: Interventional Start Date: Nov 2019 |
Xenon Inhalation Therapy for Major Depressive Disorder and Bipolar Disorder
Massachusetts General Hospital
Major Depressive Disorder
Bipolar Depression
The investigators will test the hypothesis that inhaled xenon will produce a rapid
improvement in depressive symptoms in patients suffering from treatment-resistant
depression. Specifically, the investigators will conduct a parallel randomized,
double-blind crossover study that will compare the effects... expand
The investigators will test the hypothesis that inhaled xenon will produce a rapid improvement in depressive symptoms in patients suffering from treatment-resistant depression. Specifically, the investigators will conduct a parallel randomized, double-blind crossover study that will compare the effects of xenon-oxygen (35:65 ratio by volume) added to treatment as usual (X-TAU group) to the effects of nitrogen-oxygen (35:65 ratio by volume) added to treatment as usual (N-TAU group). A total of 20 severely depressed patients, 10 with major depressive disorder (MDD) and 10 with Bipolar Depression (BP), will be exposed in random order to N-TAU and X-TAU in a double-blind protocol. Type: Interventional Start Date: Dec 2019 |
Social Support and Enhanced Fear Extinction
University of California, Los Angeles
Fear
Anxiety
University of California, Los Angeles researchers will recruit healthy participants and
anxious participants (those diagnosed with social anxiety disorder) age 18-55 years old
to participate in a study examining whether the ability of social support figure
reminders to enhance the extinction of fear... expand
University of California, Los Angeles researchers will recruit healthy participants and anxious participants (those diagnosed with social anxiety disorder) age 18-55 years old to participate in a study examining whether the ability of social support figure reminders to enhance the extinction of fear in healthy participants extends to those with anxiety disorders. After being recruited from the UCLA community (healthy participants, n = 50) or referred by treatment providers at the Anxiety and Depression Research Center at UCLA (anxious participants, n = 50) and undergoing a telephone screening and in-person screening, 100 participants will be enrolled in the study, with an expected recruited 150 to reach this number. During the experiment, all participants will undergo the same procedures: undergoing a fear extinction procedure in which threatening cues--cues that predict electric shock--will be paired with either an image of a social support figure (provided by participants) or an image of a smiling stranger. These pairings will be presented repeatedly in the absence of shock in order for fear extinction to occur. Participants will return for a follow-up test to determine if fear extinction was successful. Type: Interventional Start Date: Feb 2022 |
Using CalmiGo to Manage Anxiety and Panic Attack Symptoms in the Emergency Department
Yves Duroseau
Anxiety
Panic Attacks
Currently, there are limited options in the management of anxiety and panic attack
symptoms in the Emergency Department (ED). The most common treatment method is the use of
anti-anxiety and anti-depressant medications; however, these drugs have serious health
risks which make them ineffective as a... expand
Currently, there are limited options in the management of anxiety and panic attack symptoms in the Emergency Department (ED). The most common treatment method is the use of anti-anxiety and anti-depressant medications; however, these drugs have serious health risks which make them ineffective as a long-term treatment option. The CalmiGo handheld device, formerly known as "myReLeaf", provides an alternative early intervention option in treating patients presenting with anxiety and panic attack symptoms by using guided breathing, aromatherapy, and grounding techniques. The hypothesis of this study is that CalmiGo will provide a drug-free, early intervention, and long-term treatment option in the ED that will improve patients' anxiety and panic attack symptoms. Patients who present to the ED with anxiety or panic attack symptoms will be considered eligible for this study. These patients will be approached, and they will give informed consent to participate in the study. Patients will be enrolled in the study which consists of completing validated surveys asking about their anxiety and panic symptoms, using CalmiGo, and allowing investigators to access their medical records. These surveys will be completed before and after using CalmiGo in the ED to measure the presence and severity of anxiety and panic symptoms. The goal of this study is to analyze the effectiveness of using CalmiGo to improve anxiety and panic attack symptoms based on validated survey responses. Overall, this study seeks to identify CalmiGo as an effective and alternative early intervention treatment option for patients presenting to the ED with anxiety or panic attack symptoms. Type: Interventional Start Date: Aug 2019 |
The Role of Social Determinants in Cardiovascular Health and Vascular Function
Baylor Research Institute
Social Determinants of Health
Major Depressive Disorder
Cardiovascular Diseases
This study aims to identify the influence of social determinants of health domains on
vascular function in a low income, racial, and ethnic minority population at risk for
disparities. We hypothesize that individuals of a lower social economic position and
those struggling with depression are at greater... expand
This study aims to identify the influence of social determinants of health domains on vascular function in a low income, racial, and ethnic minority population at risk for disparities. We hypothesize that individuals of a lower social economic position and those struggling with depression are at greater risk of cardiovascular disease. Type: Interventional Start Date: Jun 2023 |
A Behavioral Activation Intervention Administered in a College Freshman Orientation Course
University of Kansas
Alcohol; Use, Problem
Stress
Binge Eating
Depression
The transition from high school to college is a developmentally sensitive period that is
high risk for escalations in alcohol use. Although risky drinking is a common problem
among freshmen, engagement in treatment services is very low. The proposed study will
test a behavioral activation intervention... expand
The transition from high school to college is a developmentally sensitive period that is high risk for escalations in alcohol use. Although risky drinking is a common problem among freshmen, engagement in treatment services is very low. The proposed study will test a behavioral activation intervention that addresses factors limiting participation in standard treatment services by targeting alcohol use indirectly, by directly addressing concerns most relevant to incoming college freshmen, and by integrating an intervention into the college curriculum. Type: Interventional Start Date: Sep 2019 |
Facing Your Fears: Adolescents With ASD and Intellectual Disability
University of Colorado, Denver
Autism Spectrum Disorder
Intellectual Disability
Anxiety
Emotion Regulation
Adolescents with ASD and intellectual disability (ID) are a complex and underserved
population. Approximately 50% of individuals with ASD/ID experience significant anxiety.
Yet, there are very limited mental health care interventions available for this
population. Addressing anxiety and building coping... expand
Adolescents with ASD and intellectual disability (ID) are a complex and underserved population. Approximately 50% of individuals with ASD/ID experience significant anxiety. Yet, there are very limited mental health care interventions available for this population. Addressing anxiety and building coping skills is particularly important during adolescence as coping skills can support a successful transition to adulthood and family functioning during a difficult developmental period. The current investigators adapted a cognitive behavioral treatment (CBT) manualized intervention, Facing Your Fears, for adolescents with ASD/ID (FYF:ASD/ID) and completed a pilot study with 23 teens. Preliminary results indicated significant improvements in anxiety and mood symptoms. The proposed study seeks to test whether FYF:ASD/ID is more effective in reducing anxiety than treatment-as-usual (TAU). The investigators propose a Randomized Control Trial (RCT) with 36 adolescents with ASD/ID (12-18 years) randomized to FYF: ASD/ID and 36 adolescents randomized to TAU for 14 weeks. The 36 teens randomized to TAU will then cross-over and complete FYF:ASD/ID. Evaluations will take place at Baseline, Post-Intervention, and 6-month follow-up. Teens in the TAU will have two baseline assessments prior to crossing over to FYF:ASD/ID; both groups will complete a 6-month follow-up assessment after finishing FYF:ASD/ID. There are three aims for this project: (1) examine the efficacy of FYF: ASD/ID relative to TAU in improving anxiety as measured by parent report and determine if any gains noted in the FYF:ASD/ID are maintained at 6-month follow-up; (2) examine secondary outcomes of anxiety such as how emotion regulation and problem behavior are affected by participation in FYF:ASD/ID; and (3) examine whether adolescents' independent use of CBT skills (as assessed by goal attainment ratings of prompting level required to use strategies) to manage anxiety are increased following participation in FYF:ASD/ID. Type: Interventional Start Date: Sep 2021 |
Using Machine Learning to Optimize User Engagement and Clinical Response to Digital Mental Health Interventions
Boston University Charles River Campus
Anxiety Disorders and Symptoms
Depressive Symptoms
Digital mental health interventions are a cost-effective and efficient approach to
expanding the accessibility and impact of psychological treatments; however, little
guidance exists for selecting the most effective program for a given individual. In the
proposed study, decision rules will develop... expand
Digital mental health interventions are a cost-effective and efficient approach to expanding the accessibility and impact of psychological treatments; however, little guidance exists for selecting the most effective program for a given individual. In the proposed study, decision rules will develop for selecting the digital program that is most likely to be the optimal intervention for each user. These treatment recommendations can be implemented in the context of large healthcare delivery systems to improve the delivery of digital mental health interventions at scale. The overarching aim of the current study is to better understand for whom and how leading digital interventions work in a large healthcare setting. The study builds on the existing literature and follows expert recommendations by using machine learning (ML) methods to develop precision treatment rules (PTRs) for three leading digital interventions for emotional disorders (e.g., anxiety, depression, and related mental health disorders). Specifically, ML methods will be used to develop PTRs to optimize clinical outcomes and associated intervention engagement. This study will leverage a unique partnership between Boston University (BU), SilverCloud Health (SC)--a leading provider of digital mental health care--and Kaiser Permanente (KP)--one of America's leading health care providers. A clinical trial (RCT) will be conducted to evaluate the relative effectiveness of three distinct empirically supported digital mental health interventions (from SC's existing library of programs) in a sample recruited from KP primary care and other clinical settings. Data from this trial will be used to develop theoretically and empirically informed, reliable selection algorithms for managing treatment delivery decisions. Algorithms will be validated in a separate "holdout" dataset by examining whether allocation to predicted optimal treatment is associated with superior outcomes compared to allocation to a non-optimal treatment. The role of user engagement will be determined, and other mechanisms in treatment outcome. Type: Interventional Start Date: Apr 2023 |
Trial of Naproxen Sodium for the Treatment of OCD in Children With PANDAS
Massachusetts General Hospital
PANDAS
Anxiety Disorder
Autoimmune Diseases
Obsessive-Compulsive Disorder
This project aims to rigorously evaluate a potential treatment for inflammation-related
Obsessive-Compulsive Disorder (OCD) symptoms in children. To accomplish this goal, the
investigators will conduct a double-blind, randomized, placebo-controlled trial of
Naproxen Sodium, a nonsteroidal anti-inflammatory... expand
This project aims to rigorously evaluate a potential treatment for inflammation-related Obsessive-Compulsive Disorder (OCD) symptoms in children. To accomplish this goal, the investigators will conduct a double-blind, randomized, placebo-controlled trial of Naproxen Sodium, a nonsteroidal anti-inflammatory drug (NSAID) in participants diagnosed with Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal infections (PANDAS). This research fills a gap in the empirical evidence base for the treatment of PANDAS, and will add to a growing literature of empirically-derived practices for PANDAS. Type: Interventional Start Date: Oct 2020 |
Flourishing and Virtue in Cognitive-Behavioral Therapy for Anxiety and Depressive Disorders
Boston University Charles River Campus
Anxiety Disorders
Depressive Disorder
This two phase study is testing an online version of a transdiagnostic, cognitive
behavioral therapy, against a modified version of that therapy emphasizing positive
affect. The first phase of the trial will focus on content development for the modified
therapy and the second phase will be a randomized... expand
This two phase study is testing an online version of a transdiagnostic, cognitive behavioral therapy, against a modified version of that therapy emphasizing positive affect. The first phase of the trial will focus on content development for the modified therapy and the second phase will be a randomized control trial comparing the two. Type: Interventional Start Date: Mar 2021 |
Improving Access to Child Anxiety Treatment
Bradley Hospital
Obsessive-Compulsive Disorder
Anxiety Disorders
Pediatric Disorder
Anxiety
OCD
There is strong evidence that cognitive behavioral therapy (CBT) with exposure is the
preferred treatment for youth with anxiety disorders, but outpatient services that
provide this type of treatment are limited. Even for those who do have access to
anxiety-specific treatment, a traditional outpatient... expand
There is strong evidence that cognitive behavioral therapy (CBT) with exposure is the preferred treatment for youth with anxiety disorders, but outpatient services that provide this type of treatment are limited. Even for those who do have access to anxiety-specific treatment, a traditional outpatient model of treatment delivery may not be suitable. Among the numerous logistical barriers to treatment access and response is the inability to generalize treatment tools to settings outside of the office. Patient-centered (home-based or telehealth; patient-centered telehealth closed as of 5/1/21) treatment models that target symptoms in the context in which they occur could be more effective, efficient, and accessible for families. The present study aims to compare the efficacy, efficiency, and feasibility of patient centered home-based CBT and patient centered telehealth CBT with a traditional office-based model of care. The question proposed, including proposed outcomes, have been generated and developed by a group of hospital, payer, patient and family stakeholders who will also contribute to the iterative process of protocol revision. The investigators anticipate 379 anxious youth to be randomized to receive outpatient treatment using telehealth (patient-centered telehealth closed as of 5/1/21), home-based services, or treatment as usual using a traditional outpatient model. Results of this study are expected to provide evidence for the efficacy and efficiency of patient-centered treatment, as well as increase treatment access and family engagement in the treatment process. Type: Interventional Start Date: Jul 2018 |
Brief Smartphone Treatment Study
Penn State University
Generalized Anxiety Disorder
Little is known about whether and how brief mindfulness therapies yield clinically
beneficial effects. This gap exists despite the rapid growth of smartphone mindfulness
applications and presence of mental health treatment gap. Specifically, no prior brief,
smartphone mindfulness ecological momentary... expand
Little is known about whether and how brief mindfulness therapies yield clinically beneficial effects. This gap exists despite the rapid growth of smartphone mindfulness applications and presence of mental health treatment gap. Specifically, no prior brief, smartphone mindfulness ecological momentary intervention (MEMI) has targeted generalized anxiety disorder (GAD). Moreover, although theories propose that mindfulness intervention can boost attentional control (AC), executive functioning (EF), perspective-taking, and social cognition skills they have largely gone untested. Thus, this randomized controlled trial (RCT) aims to address these gaps by assessing the efficacy of a 14-day smartphone mindfulness EMI (vs. placebo). Participants with GAD will be randomly assigned to either MEMI or self-monitoring placebo (SMP). Those in treatment will exercise multiple core mindfulness strategies (open monitoring, acceptance, attending to small moments, slowed rhythmic diaphragmatic breathing). Also, those in MEMI will be reminded before bedtime that mindfulness is a lifelong practice. Comparatively, participants assigned to SMP will only be prompted to practice self-monitoring. They will notice their thoughts, rate any distress associated with them, and will not be taught any mindfulness strategies. All prompts will occur 5 times a day, for 14 consecutive days. They will complete self-reports and neuropsychological assessments at pre-, post-, and 1-month follow-up. Multilevel modeling analyses will determine if treatment (vs. self-monitoring placebo (SMP)) produces substantially larger reductions in trait worry and negative perseverative cognitions as well as steeper increases in AC and EF (inhibition, set-shifting, working memory updating). In addition, the investigators hypothesized that MEMI (vs. SMP) would lead to greater increases in performance-based and self-reported trait mindfulness, empathy, and perspective taking. Findings will advance understanding of the efficacy of unguided, technology-assisted, brief mindfulness in a clinical sample. Type: Interventional Start Date: Nov 2018 |
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