Search Clinical Trials
Before medications are approved by the U.S. Food and Drug Administration (FDA) or before certain therapy methods are widely accepted as effective, they are tested on people who volunteer to participate in a clinical trial.
Organizations across the country are looking for people like you to take part in their research studies. The list of studies below have been selected from ClinicalTrials.gov based on their inclusion of one or more of the following terms: anxiety disorders, depression, OCD, PTSD, and bipolar disorder.
The Anxiety and Depression Association of America (ADAA) is supportive of research that is conducted through clinical trials. Participating in research can potentially help change the mental health outcomes for you and others who suffer anxiety, depression, and related disorders. You may learn about new interventions/treatments that are being considered. This website page is brought to you in partnership with ResearchMatch.
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CRISOL Mente: A Multilevel Community Intervention to Reduce Mental Health Disparities Among Latinos
Drexel University
Depression, Unipolar
Anxiety Disorders
Post Traumatic Stress Disorder
Latinos in the U.S. experience significant disparities in access to mental health
services due to lack of health insurance, language barriers, low availability of
bilingual providers, mental health stigma, and fear of deportation. There is an urgent
need to identify low-cost, culturally appropriate... expand
Latinos in the U.S. experience significant disparities in access to mental health services due to lack of health insurance, language barriers, low availability of bilingual providers, mental health stigma, and fear of deportation. There is an urgent need to identify low-cost, culturally appropriate interventions to reduce mental health disparities among this population. This project will address that need by implementing and testing CRISOL Mente, a multi-level, culturally-congruent community intervention to improve the mental health of the Latino population in Philadelphia. Type: Interventional Start Date: Nov 2023 |
Prevention of Anhedonia in Children
Vanderbilt University
Anhedonia
Depression
This trial will test the effects of a positive emotion-focused preventive intervention on
reward responsiveness in children of mothers with histories of depression and anhedonia. expand
This trial will test the effects of a positive emotion-focused preventive intervention on reward responsiveness in children of mothers with histories of depression and anhedonia. Type: Interventional Start Date: Nov 2023 |
Feasibility and ML Training Investigation of the Senseye DT for Diagnosis of Adults With PTSD
Senseye, Inc.
PTSD
Generalized Anxiety Disorder
Major Depressive Disorder
The aim of this study is to obtain data on the feasibility of the Senseye Diagnostic Tool
(DT) to assess the presence and severity of post-traumatic stress disorder (PTSD)
symptoms. The study will also collect data on Generalized Anxiety Disorder (GAD) and
Major Depressive Disorder (MDD) to aid in... expand
The aim of this study is to obtain data on the feasibility of the Senseye Diagnostic Tool (DT) to assess the presence and severity of post-traumatic stress disorder (PTSD) symptoms. The study will also collect data on Generalized Anxiety Disorder (GAD) and Major Depressive Disorder (MDD) to aid in assessing the presence and severity of these disorders both for the purpose of discerning them from PTSD and determining the feasibility of diagnosing them independently. Type: Observational Start Date: Mar 2023 |
Acceptance and Commitment Therapy (ACT) for Combating the Effects of Race-Related Stress Among Black...
Children's Hospital Los Angeles
Race-related Stress
Depression, Anxiety
Quality of Life
Stress Reaction
The current study seeks to build on previous research that demonstrates the efficacy of
Acceptance and Commitment Therapy in combating stigma by investigating the feasibility
and acceptability of a protocol to support Black adolescents and young adults in coping
with race related stress. The study... expand
The current study seeks to build on previous research that demonstrates the efficacy of Acceptance and Commitment Therapy in combating stigma by investigating the feasibility and acceptability of a protocol to support Black adolescents and young adults in coping with race related stress. The study will consist of a small, purposeful, non-randomized sample (N = 30) of clients enrolled into a 10-session Acceptance and Commitment Therapy group. The group will be offered as part of regular clinical care at the Division of Adolescent and Young Adult Medicine. Three consecutive groups will be run with approximately 8-10 participants in each group over the next year. Type: Interventional Start Date: Aug 2023 |
Clinical Study Evaluating Pharmacogenomics-informed Pharmacotherapy Versus Dosing as Usual in Psychiatric...
Maastricht University Medical Center
Mood Disorders
Anxiety Disorders
Psychotic Disorders
A 24-week, patient- and rater-blinded, two-arm, parallel-group controlled, and
multi-centre randomized clinical trial (RCT) to establish the benefits of
pharmacogenetics-informed pharmacotherapy versus dosing as usual (DAU) in psychiatric
patients suffering from mood, anxiety, or psychotic disorders. expand
A 24-week, patient- and rater-blinded, two-arm, parallel-group controlled, and multi-centre randomized clinical trial (RCT) to establish the benefits of pharmacogenetics-informed pharmacotherapy versus dosing as usual (DAU) in psychiatric patients suffering from mood, anxiety, or psychotic disorders. Type: Interventional Start Date: Feb 2023 |
Children's Bipolar Network Treatment Trial I
University of California, Los Angeles
Bipolar Disorder
Bipolar I Disorder
Bipolar II Disorder
Other Specified Bipolar and Related Disorder
Mood Instability
This is a naturalistic treatment and follow-up study of youth with bipolar spectrum
disorders (BSDs) across four US sites of The Childhood Bipolar Network (CBN). CBN sites
have expertise in diagnosing, assessing, and treating BSDs in youth. The primary aims of
this study are to (1) identify and reliably... expand
This is a naturalistic treatment and follow-up study of youth with bipolar spectrum disorders (BSDs) across four US sites of The Childhood Bipolar Network (CBN). CBN sites have expertise in diagnosing, assessing, and treating BSDs in youth. The primary aims of this study are to (1) identify and reliably diagnose youth (ages 9 to 19 yrs) with full bipolar disorder (BD) and BSDs, and (2) examine predictors (e.g., mood instability, inflammatory marker C-reactive protein) of clinical outcome over a 12 month period. Participating youth will initially complete a screening that includes a structured diagnostic interview and a baseline blood draw to measure inflammatory processes. Youth with BSD and parents (80 families) will be asked to participate in multiple follow up research visits with interviews, rating instruments, and questionnaires. Per established CBN guidelines, study psychiatrists will provide and track medication management and sites will also track psychosocial treatments. This study ultimately aims to further understanding of best practice pediatric BSD psychiatric and psychosocial treatments and development of a standardized and validated set of clinical tools for patient assessment, diagnosis, and tracking. Type: Observational Start Date: Jul 2022 |
Rapid Acting Transcranial Magnetic Stimulation
Stanford University
Treatment Resistant Depression
This study evaluates an accelerated schedule of theta-burst stimulation using a
transcranial magnetic stimulation device for treatment-resistant depression. In a
double-blind, randomized, sham-controlled fashion, half the participants will receive
accelerated theta-burst stimulation while half will... expand
This study evaluates an accelerated schedule of theta-burst stimulation using a transcranial magnetic stimulation device for treatment-resistant depression. In a double-blind, randomized, sham-controlled fashion, half the participants will receive accelerated theta-burst stimulation while half will receive sham treatment. Type: Interventional Start Date: Jun 2021 |
Establishing a Dose-response Relationship With Accelerated Transcranial Magnetic Stimulation
Stanford University
Treatment Resistant Depression
This study evaluates an accelerated schedule of theta-burst stimulation using a
transcranial magnetic stimulation device for treatment-resistant depression. In a
double-blind, randomized, sham-controlled fashion, half the participants will receive
accelerated theta-burst stimulation while half will... expand
This study evaluates an accelerated schedule of theta-burst stimulation using a transcranial magnetic stimulation device for treatment-resistant depression. In a double-blind, randomized, sham-controlled fashion, half the participants will receive accelerated theta-burst stimulation while half will receive sham treatment. Type: Interventional Start Date: Jun 2021 |
African American Families Fighting Parental Cancer Together
University of Delaware
Depressive Symptoms
Anxiety
Parental Stress
The purpose of this study is to test the usefulness of a family-based program for African
American parents/primary caregivers with newly diagnosed solid tumor cancer and their
adolescent children. The program is designed to promote family communication reduce and
depressive symptoms for adolescence. expand
The purpose of this study is to test the usefulness of a family-based program for African American parents/primary caregivers with newly diagnosed solid tumor cancer and their adolescent children. The program is designed to promote family communication reduce and depressive symptoms for adolescence. Type: Interventional Start Date: Oct 2018 |
Study of the Efficacy of Lurasidone in Cognitive Functioning in Bipolar Patients
Nazlin Walji
Bipolar Disorder
This is a randomized, double-blind, placebo-controlled, multicentre, parallel-group study
to assess the cognitive effects of lurasidone in bipolar I and II patients (manic
depression) who are in remission from an episode. Participants who show cognitive
impairment at the screening visit will be enrolled... expand
This is a randomized, double-blind, placebo-controlled, multicentre, parallel-group study to assess the cognitive effects of lurasidone in bipolar I and II patients (manic depression) who are in remission from an episode. Participants who show cognitive impairment at the screening visit will be enrolled into the study and randomized at the baseline visit to receive either lurasidone or placebo adjunctive therapy in a 1:1 ratio for 6 weeks. Type: Interventional Start Date: May 2017 |
Adolescent Mood During Puberty and Testosterone
University of North Carolina, Chapel Hill
Adolescent Depression
Starting at puberty, female adolescents are nearly three-times more likely to develop
internalizing disorders, like depression, while male adolescents are two-times more
likely to develop externalizing disorders, like attention deficit hyperactivity disorder
(ADHD). This divergence between the sexes... expand
Starting at puberty, female adolescents are nearly three-times more likely to develop internalizing disorders, like depression, while male adolescents are two-times more likely to develop externalizing disorders, like attention deficit hyperactivity disorder (ADHD). This divergence between the sexes during puberty suggests sex-specific pathways of risk and differential effects of sex hormones. The purpose of this research is to determine: 1) sex-specific neural and endocrine features of the pubertal transition that may mediate sex differences in adolescent mood disorders, and 2) the neurophysiological basis of susceptibility to hormone change during puberty. Type: Interventional Start Date: Aug 2023 |
Unified Protocol: Community Connections
University of Miami
Mental Health Issue
Anxiety Disorder
Depressive Disorder
Parenting
The purpose of this study is to administer the Unified Protocols for Transdiagnostic
Treatment of Emotional Disorders in Children (UP-C) and Adolescents (UP-A) to youth and
participants' parents and to examine the efficacy and outcomes of the treatment using
standardized measures, questionnaires,... expand
The purpose of this study is to administer the Unified Protocols for Transdiagnostic Treatment of Emotional Disorders in Children (UP-C) and Adolescents (UP-A) to youth and participants' parents and to examine the efficacy and outcomes of the treatment using standardized measures, questionnaires, interviews. The UP-C and the UP-A are cognitive-behavioral therapies to treat emotional disorders. Type: Interventional Start Date: Sep 2023 |
Preventing Postpartum Depression in Immigrant Latinas
Northwestern University
Postpartum Depression
Postpartum depression (PPD) affects 10-20% of women, with immigrant Latinas
disproportionately affected. PPD prevention and treatment is limited among immigrant
Latinas due to an array of structural and cultural factors, suggesting the need to
deliver interventions outside of traditional healthcare... expand
Postpartum depression (PPD) affects 10-20% of women, with immigrant Latinas disproportionately affected. PPD prevention and treatment is limited among immigrant Latinas due to an array of structural and cultural factors, suggesting the need to deliver interventions outside of traditional healthcare settings. Virtual interventions have the potential to reduce barriers to mental health services for immigrant Latinas, but there is little research on the effectiveness of virtual interventions to reduce PPD symptoms. Mothers and Babies is an evidence-based group intervention based on principles of cognitive-behavioral therapy and attachment theory aimed at PPD prevention. Mothers and Babies was adapted for delivery via a virtual group format (Mothers and Babies Virtual Group; MB-VG), with a pilot study suggesting good feasibility and acceptability as well as improved mental health outcomes for immigrant Latinas. The proposed project is a Type 1 Effectiveness-Implementation randomized controlled trial among pregnant individuals and new mothers at risk for PPD based on elevated depressive symptoms and/or other established risk factors who are enrolled in early childhood programs across Maryland. A total of 300 women will be enrolled; 150 will receive MB-VG while 150 will receive usual family support services. The project aims to evaluate: 1) the effectiveness of MB-VG to reduce depressive symptoms, prevent onset of PPD, and improve parenting self-efficacy and responsiveness; 2) implementation of MB-VG; and 3) contextual factors influencing MB-VG effectiveness and implementation. Trained early childhood center staff will deliver MB-VG sessions, with intervention participants receiving virtual group sessions via Zoom using any electronic device (smartphone, tablet, laptop). Maternal self-report surveys are conducted at baseline, 1 week, 3 months, and 6 months post-intervention, with structured clinical interviews also conducted at 3- and 6-months post-intervention. The study is the first to deliver a virtual PPD preventive intervention to immigrant Latinas and to evaluate its impact. Given its virtual delivery modality, MB-VG can be easily replicated and scaled to other family support programs and settings serving immigrant Latinas. If effective and implemented broadly, more immigrant Latinas will receive mental health services and fewer will suffer the negative consequences associated with PPD. Type: Interventional Start Date: Oct 2023 |
Triage Survey for Psychiatry Research Eligibility
Adams Clinical
Major Depressive Disorder
Borderline Personality Disorder
Generalized Anxiety Disorder
TRIAGE-Psych is a survey study designed to assess potential participants' eligibility to
screen for industry-sponsored psychiatry clinical trials. expand
TRIAGE-Psych is a survey study designed to assess potential participants' eligibility to screen for industry-sponsored psychiatry clinical trials. Type: Observational Start Date: Dec 2021 |
VR to Reduce Pain/Anxiety During Painful Procedures
Children's Hospital Los Angeles
Phlebotomy
Orthopedics
Radiology
Pain
Anxiety
This study aims to test the effectiveness of virtual reality (VR) as a non-pharmaceutical
intervention to reduce pain and anxiety in children undergoing painful procedures in
Phlebotomy, Radiology, Infusion, Orthopedics, Gastroenterology, and Immunology, amongst
others, at CHLA, as measured by self-... expand
This study aims to test the effectiveness of virtual reality (VR) as a non-pharmaceutical intervention to reduce pain and anxiety in children undergoing painful procedures in Phlebotomy, Radiology, Infusion, Orthopedics, Gastroenterology, and Immunology, amongst others, at CHLA, as measured by self- and proxy-report. Examples of the painful procedures include IV sticks, cast removals, allergy testing, and anorectal manometries. Type: Interventional Start Date: Feb 2016 |
Preventing Anxiety and Depression in Older Hispanics
University of Miami
Depression
Anxiety
The purpose of this study is to look at the best ways to prevent anxiety and depression
in older Latino adults who are at risk for developing anxiety and depression.
Participants will be randomized to either a health promotion intervention or a healthy
lifestyles education program. expand
The purpose of this study is to look at the best ways to prevent anxiety and depression in older Latino adults who are at risk for developing anxiety and depression. Participants will be randomized to either a health promotion intervention or a healthy lifestyles education program. Type: Interventional Start Date: Nov 2022 |
Neuromodulation for Comorbid Hoarding Disorder and Depression
University of California, San Diego
Hoarding Disorder
Hoarding
Depression
The primary goal of this study is to evaluate whether intermittent theta burst
stimulation (iTBS) is effective for treating depression in people who have depression and
chronic hoarding disorder (HD). The study will also evaluate whether this treatment can
improve HD symptoms, cognitive performance,... expand
The primary goal of this study is to evaluate whether intermittent theta burst stimulation (iTBS) is effective for treating depression in people who have depression and chronic hoarding disorder (HD). The study will also evaluate whether this treatment can improve HD symptoms, cognitive performance, and brain region connectivity. The study team will investigate how the treatment works for depression, as well as other factors that can enhance or hinder treatment, such as pre-treatment level of depression, cognitive performance, or brain region connectivity. Type: Interventional Start Date: Aug 2023 |
Perinatal Depression and Adverse Childhood Experiences: Prevention Trial
Northwestern University
Perinatal Depression
The goal of this clinical trial is to evaluate the impact of ROSE in individuals with
adverse childhood experiences. The main question it aims to answer is, compared to
enhanced treatment as usual, does the delivery of ROSE within a collaborative care model
improve depressive symptom trajectories... expand
The goal of this clinical trial is to evaluate the impact of ROSE in individuals with adverse childhood experiences. The main question it aims to answer is, compared to enhanced treatment as usual, does the delivery of ROSE within a collaborative care model improve depressive symptom trajectories and prevent the development of perinatal depression. Participants will be randomized to either enhanced treatment as usual or the ROSE intervention, delivered by a care manager within a perinatal collaborative care program. They will complete self-reported surveys of their depression symptoms every 4 weeks to inform their symptom trajectories. They will also complete clinical interviews to establish any incident diagnoses of a major depressive episode. Type: Interventional Start Date: Jul 2023 |
Combined Neuromodulation and Cognitive Training for Post-mTBI Depression
University of California, San Diego
Depression
Mild Traumatic Brain Injury
Concussion, Brain
The primary goal of this clinical trial is to evaluate whether Personalized Augmented
Cognitive Training (PACT) plus intermittent theta burst stimulation (iTBS) is effective
for treating depression in Service Members, Veterans, and civilians who have sustained a
mild TBI. Participants will receive... expand
The primary goal of this clinical trial is to evaluate whether Personalized Augmented Cognitive Training (PACT) plus intermittent theta burst stimulation (iTBS) is effective for treating depression in Service Members, Veterans, and civilians who have sustained a mild TBI. Participants will receive PACT plus 20 sessions of iTBS or sham iTBS over 4 weeks. Assessments will occur at baseline, 2 weeks, 4 weeks, and 8 weeks. Researchers will compare the PACT+iTBS group to the PACT+sham iTBS group to see if PACT+iTBS is associated with more depression improvement. Type: Interventional Start Date: Sep 2023 |
Dasatinib Plus Quercetin for Accelerated Aging in Mental Disorders
Washington University School of Medicine
Schizophrenia
Treatment Resistant Depression
Aging, Premature
This pilot open-label study examines the effects of a combination of dasatinib plus
quercetin - two drugs that have known senolytics properties - on physiological aging in
older individuals with depression or schizophrenia. expand
This pilot open-label study examines the effects of a combination of dasatinib plus quercetin - two drugs that have known senolytics properties - on physiological aging in older individuals with depression or schizophrenia. Type: Interventional Start Date: Jul 2023 |
The Families and Middle School Success Project
University of Oregon
Parenting
Parent-Child Relations
Self-regulation
Problem Behavior in School
School Adjustment
The purpose of the proposed research is to conduct an efficacy trial of the Family
Check-Up (FCU) Online to prevent emotional and behavioral disorders among middle-school
students at-risk for disability during the transition back to school after the COVID-19
pandemic. Mental health and behavior problems... expand
The purpose of the proposed research is to conduct an efficacy trial of the Family Check-Up (FCU) Online to prevent emotional and behavioral disorders among middle-school students at-risk for disability during the transition back to school after the COVID-19 pandemic. Mental health and behavior problems are at epidemic proportions as a result of the COVID-19 pandemic, with the highest rates in adolescents and children with disabilities. We propose to evaluate the efficacy of the FCU Online, a school-based, ecological approach to family intervention and risk reduction, across a group of students at-risk or identified with disability during the middle school years. The FCU Online for middle school youth has been evaluated in a randomized trial in prior research during the development of the program but has never been tested as a large-scale, school-based intervention or delivered by providers working in schools. It has recently been adapted for COVID-19 and includes new modules on coping with stress and home-to-school engagement to support the return to school after COVID-19 for students at-risk. Students in schools will be identified for services using indicators that are natural to the school environment (attendance, office discipline referrals, and grades), and will be followed for 2 years. We predict that engagement in the FCU Online will be associated with student reductions in emotional and behavior problems, improvements in academic skills, and improvements in attendance. Parenting skills such as home-to-school communication, positive parenting, and behavioral routines will be tested as mediators of intervention efficacy. Type: Interventional Start Date: May 2022 |
Determining Efficacy and Safety of BXCL501 in Agitation Associated With Pediatric Schizophrenia and Bipolar...
BioXcel Therapeutics Inc
Schizophrenia
Schizo-Affective Disorder
Schizophreniform; Schizophrenic
Bipolar Disorder I
Bipolar Disorder II
This is a study of the efficacy and safety of BXCL501 in children and adolescents with
acute agitation and either bipolar disorder or schizophrenia. expand
This is a study of the efficacy and safety of BXCL501 in children and adolescents with acute agitation and either bipolar disorder or schizophrenia. Type: Interventional Start Date: Aug 2021 |
Safe Mothers, Safe Children Initiative
New York University
PTSD
Depression
Child Maltreatment
The purpose of this study is to assess the efficacy of the combined interventions, Skills
Training in Affective and Interpersonal Regulation (STAIR) and Parent-Child Interaction
Therapy (PCIT) or P-STAIR, for treating maternal PTSD and reducing maltreatment
recidivism. expand
The purpose of this study is to assess the efficacy of the combined interventions, Skills Training in Affective and Interpersonal Regulation (STAIR) and Parent-Child Interaction Therapy (PCIT) or P-STAIR, for treating maternal PTSD and reducing maltreatment recidivism. Type: Interventional Start Date: May 2021 |
Testing FIRST in Youth Outpatient Psychotherapy
Harvard University
Anxiety
Depression
Trauma
Behavior Problem
The study will compare the impact FIRST (a transdiagnostic treatment built upon five
empirically supported principles of change) versus usual care outpatient psychotherapy on
youths' mental health outcomes and a candidate mechanism of change: regulation of
negative emotions. expand
The study will compare the impact FIRST (a transdiagnostic treatment built upon five empirically supported principles of change) versus usual care outpatient psychotherapy on youths' mental health outcomes and a candidate mechanism of change: regulation of negative emotions. Type: Interventional Start Date: Sep 2021 |
Fitness for Brain Optimization for Late-Life Depression
University of Pittsburgh
Depression in Old Age
Cognitive impairment and brain abnormalities are common and persist after depression
remission in those with Late Life Depression (LLD), compounding dementia risk in both
individuals with acute and remitted LLD (rLLD). In this study, investigators will examine
systemic neural and cognitive benefits... expand
Cognitive impairment and brain abnormalities are common and persist after depression remission in those with Late Life Depression (LLD), compounding dementia risk in both individuals with acute and remitted LLD (rLLD). In this study, investigators will examine systemic neural and cognitive benefits of aerobic exercise training in older adults with remitted LLD. This will generate preliminary data regarding neural targets of aerobic exercise training that may translate to cognitive benefits in those with rLLD, a population who remains at high risk for dementia despite successful treatment of depression. Type: Interventional Start Date: Aug 2021 |
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