Search Clinical Trials
Before medications are approved by the U.S. Food and Drug Administration (FDA) or before certain therapy methods are widely accepted as effective, they are tested on people who volunteer to participate in a clinical trial.
Organizations across the country are looking for people like you to take part in their research studies. The list of studies below have been selected from ClinicalTrials.gov based on their inclusion of one or more of the following terms: anxiety disorders, depression, OCD, PTSD, and bipolar disorder.
The Anxiety and Depression Association of America (ADAA) is supportive of research that is conducted through clinical trials. Participating in research can potentially help change the mental health outcomes for you and others who suffer anxiety, depression, and related disorders. You may learn about new interventions/treatments that are being considered. This website page is brought to you in partnership with ResearchMatch.
Sponsor Condition of Interest |
---|
Study to Assess the Effects of Oral NMRA-335140 Versus Placebo in Participants With Major Depressive...
Neumora Therapeutics, Inc.
Major Depressive Disorder
This is a randomized, double-blind, placebo-controlled, multicenter study to evaluate the
effects of NMRA-335140 (formerly BTRX-335140) on symptoms of depression in participants
with Major Depressive Disorder (MDD). The study design consists of a Screening Period (up
to 28 days), and a 6-week Treatment... expand
This is a randomized, double-blind, placebo-controlled, multicenter study to evaluate the effects of NMRA-335140 (formerly BTRX-335140) on symptoms of depression in participants with Major Depressive Disorder (MDD). The study design consists of a Screening Period (up to 28 days), and a 6-week Treatment Period (during which participants will receive either NMRA-335140 or placebo). At the completion of the 6-week Treatment Period, participants who complete the study, provide informed consent, and meet the eligibility criteria may enter an open-label extension study (NMRA-335140-501). Type: Interventional Start Date: Dec 2023 |
Prenatal Yoga to Prevent Postpartum Depression
Henry Ford Health System
Postpartum Depression
Although psychological interventions exist for the prevention of PPD, a yoga-based
intervention to prevent PPD among at-risk women utilizes a similar theoretical foundation
(i.e., mindfulness), may be more acceptable to women of minority status, and may confer
additional physical activity benefits.... expand
Although psychological interventions exist for the prevention of PPD, a yoga-based intervention to prevent PPD among at-risk women utilizes a similar theoretical foundation (i.e., mindfulness), may be more acceptable to women of minority status, and may confer additional physical activity benefits. The purpose of this pilot study is to determine the effectiveness of using a virtually delivered prenatal yoga intervention for the prevention of PPD among at-risk women in a diverse health care system and explore preliminary factors which influence implementation of the intervention. This study has 2 phases: Phase 1 will evaluate facilitators and barriers to intervention implementation among patient, clinician, and health system stakeholders, followed by an open trial, and Phase 2 will include conducting an 8-session pilot randomized controlled trial to assess the feasibility and acceptability of the proposed prenatal yoga intervention among women with a history of depression, as well as the onset and course of PPD and mediating factors. The specific aims are to: 1) Optimize delivery of a yoga intervention within a healthcare system to prevent PPD through examining facilitators and barriers of implementation, 2) Examine feasibility, acceptability and satisfaction of the intervention within a health care system, and 3) Evaluate preliminary effectiveness of the intervention on PPD and proposed mechanisms. For Phase 1, separate focus groups with patient stakeholders and clinician and administrative stakeholders will inform intervention implementation, and an open trial to refine and optimize the intervention. For Phase 2, women with a history of depression who are 8-28 weeks pregnant will be randomized to the intervention group (n=24) or treatment-as-usual (n=24) and will complete survey measures at baseline, post-intervention, and 1 and 3 months postpartum. It is hypothesized that the intervention will be feasible and acceptable, engage women of racial/ethnic minority status, and contribute to lower rates of PPD onset. Embodiment and mindfulness are the proposed mediators. Knowledge gained from this study can support prevention efforts for PPD and improve the adverse public health impact of this disorder. Type: Interventional Start Date: Oct 2024 |
REmotely-delivered Supportive Programs for Improving Surgical Pain and disTrEss
Wake Forest University Health Sciences
Postoperative Pain, Acute
Postoperative Depression
Anxiety
Sleep Disturbance
Malignant Female Reproductive System Neoplasm
The purpose of this research study is to learn how two different supportive programs may
help women feel better after surgery. This study will measure if one type of supportive
program is more useful than the other for improving wellbeing after surgery. expand
The purpose of this research study is to learn how two different supportive programs may help women feel better after surgery. This study will measure if one type of supportive program is more useful than the other for improving wellbeing after surgery. Type: Interventional Start Date: Jun 2023 |
Virtual Reality in Pediatric Dentistry
University of Southern California
Behavior, Child
Anxiety, Dental
Dental Fear and Anxiety is an emotional experiences affecting many children and
adolescents which can lead to behavioral problems in the dental setting. The purpose of
the proposed study is to investigate the effect of virtual reality on anxiety, behavior,
and pain in children undergoing restorative... expand
Dental Fear and Anxiety is an emotional experiences affecting many children and adolescents which can lead to behavioral problems in the dental setting. The purpose of the proposed study is to investigate the effect of virtual reality on anxiety, behavior, and pain in children undergoing restorative dental procedures. Children enrolled in the study will include patients ages 6-18 who are healthy and require two or more dental sealants (at least one sealant per side). The participants in the study will serve as their own control using a split-mouth cross-over randomized control clinical trial design and will be randomly assigned to receive virtual reality or traditional behavior guidance techniques first during dental sealant placement. The objectives of this study are to explore the associations between the use of virtual reality distraction during dental sealant placement with Frankl score, FLACC scale, and anxiety based on the change in heart rate, and pain based on self-reported FPS-R when compared with to the control group. The crossover design will be assessed by a linear mixed model with patient treated as a random effect. This model will include treatment, visit, treatment by visit interaction term as well as a treatment sequence variable. Prior to analysis, the primary outcome measures will be assessed for normality using a Shapiro-Wilk statistic as well as quantile-quantile (QQ) plots. Should the data deviate sharply from a normal distribution, normalizing transformations will be sought and applied to the data. Type: Interventional Start Date: Mar 2023 |
Collaborative Care for Anxiety and Depression in Epilepsy
Wake Forest University Health Sciences
Epilepsy
Anxiety
Depression
This is a randomized effectiveness/implementation trial comparing a 24-week
neurology-based collaborative care intervention to usual neurology care among 60 adults
with epilepsy. expand
This is a randomized effectiveness/implementation trial comparing a 24-week neurology-based collaborative care intervention to usual neurology care among 60 adults with epilepsy. Type: Interventional Start Date: May 2023 |
Determining the Right Acupuncture for Good Recovery Over Neuropsychiatric Trauma
Paul Crawford
PTSD
Post Traumatic Stress Disorder
Acupuncture
This study seeks to verify that a specific acupuncture treatment is effective at reducing
symptoms of neuropsychiatric trauma found in those diagnosed with Post-Traumatic Stress
Disorder (PTSD). expand
This study seeks to verify that a specific acupuncture treatment is effective at reducing symptoms of neuropsychiatric trauma found in those diagnosed with Post-Traumatic Stress Disorder (PTSD). Type: Interventional Start Date: Oct 2022 |
Sequential Allocation Study of Music Duration
Tufts Medical Center
Anxiety
Patient Satisfaction
Music Exposure
The investigators are interested in studying the effects of varying lengths of musical
exposure on patient anxiety and stress levels. expand
The investigators are interested in studying the effects of varying lengths of musical exposure on patient anxiety and stress levels. Type: Interventional Start Date: Jun 2021 |
Cannabidiol and Prolonged Exposure
VA Office of Research and Development
PTSD
The trial will include a randomized control trial to evaluate the efficacy of using
Cannabidiol (CBD), a non-intoxicating cannabinoid, as an adjunctive to Prolonged Exposure
therapy (PE). The trial will compare PE + CBD to PE + placebo in a sample of 136 military
Veterans with PTSD at the VA San Diego... expand
The trial will include a randomized control trial to evaluate the efficacy of using Cannabidiol (CBD), a non-intoxicating cannabinoid, as an adjunctive to Prolonged Exposure therapy (PE). The trial will compare PE + CBD to PE + placebo in a sample of 136 military Veterans with PTSD at the VA San Diego Medical Center. The study represents the logical and innovative next step for augmenting existing treatments and developing novel pharmacotherapy for PTSD. Findings from the proposed RCT will inform clinical practice and policy by investigating whether administration of CBD in the context of PE therapy will improve treatment outcomes for military Veterans with PTSD. Type: Interventional Start Date: Mar 2019 |
Long-term Observation of Participants With Mood Disorders
National Institute of Mental Health (NIMH)
Depression
Suicide Risk
Background:
More than 12,000 people have taken part in research at the Experimental Therapeutics &
Pathophysiology Branch at the National Institute of Mental Health Intramural Program.
This has led to advances in the treatment of depression, bipolar disorder, and suicide
risk. Researchers want... expand
Background: More than 12,000 people have taken part in research at the Experimental Therapeutics & Pathophysiology Branch at the National Institute of Mental Health Intramural Program. This has led to advances in the treatment of depression, bipolar disorder, and suicide risk. Researchers want to follow up with this group to see if they continue to have mental health symptoms and receive psychiatric treatments. Objective: To learn the long-term impact of depression, bipolar disorder, and suicide risk. Eligibility: Adults ages 18 and older who signed consent for Protocol 01-M-0254 over a year ago. Design: This study has 2 phases: an online phase and a telephone phase. It has no in-person or face-to-face contact. In Phase 1, participants will fill out online surveys. They will access the surveys through the study website. The questions will focus on their current thoughts and feelings. The surveys will also ask about their current treatments for their mental health symptoms. At the end of the surveys, they will be asked if they would like to take part in Phase 2. If so, they will mark yes. Phase 2 includes a phone interview. They will be contacted by email to schedule the interview. In Phase 2, participants will be asked more in-depth questions about how they are feeling. They will also be asked which psychiatric medicines and treatments they have used since they left NIH. In both phases, participants can skip any questions they do not want to answer. The online surveys will take 30 minutes to complete. The phone interview will last 1-4 hours. The information that participants give in this study may be linked to their other NIH research records. Type: Observational Start Date: Aug 2021 |
Transcranial Electric Stimulation Therapy (TEST) for Treatment Resistant Depression (TRD
National Institute of Mental Health (NIMH)
Major Depressive Disorder
Bipolar Disorder
Unipolar Major Depression
Background:
People with TRD are often helped by electroconvulsive therapy (ECT). But ECT can affect
memory and thinking. Researchers want to study a treatment called TEST that uses less
electricity.
Objective:
To study the safety and feasibility of TEST and assess its antidepressant effects.
Eligibility:
Adults... expand
Background: People with TRD are often helped by electroconvulsive therapy (ECT). But ECT can affect memory and thinking. Researchers want to study a treatment called TEST that uses less electricity. Objective: To study the safety and feasibility of TEST and assess its antidepressant effects. Eligibility: Adults aged 25-64 with major depression that has not been relieved by current treatments. Design: Participants will be admitted to the NIH Clinical Center for 5 18 weeks over 2 3 treatment phases. Their medications may be adjusted. Participants will be interviewed about their depression, side effects, and other treatments they are receiving. They will complete questionnaires. They will give blood and urine samples. Their brain waves and heart rhythm will be recorded. They will take tests of memory, attention, mental functioning, and thinking. Participants will have magnetic resonance imaging (MRI) scans of the head and brain. They will lie on a table that slides in and out of the scanner. Pictures of brain chemicals will also be taken. They may complete tasks during the MRI. Participants will receive TEST and/or sham treatments. They may receive optional ECT. An intravenous catheter will be placed in an arm vein to receive general anesthesia. Two electrodes will be placed on the front of their head. An electric current will be passed from the ECT machine through the electrodes. For sham treatments, they will not receive the electric current. Their breathing, heart rate, brain function, blood pressure, and body movements will be measured. Participants will have 7 follow-up visits over 6 months. Visits can be done via telehealth. Participation will last for up to 42 weeks. Type: Interventional Start Date: Nov 2022 |
Immersive Virtual Reality (VR) at the Time of Clinical Evaluation to Improve Psychological Distress and...
National Cancer Institute (NCI)
Anxiety
Background:
Distress, anxiety, and other psychological disorders may be more common in people with
primary brain tumors (PBTs). PBTs can affect their symptoms, quality of life, and their
tolerance of cancer treatments. Researchers want to learn if virtual reality (VR)
technology can help reduce... expand
Background: Distress, anxiety, and other psychological disorders may be more common in people with primary brain tumors (PBTs). PBTs can affect their symptoms, quality of life, and their tolerance of cancer treatments. Researchers want to learn if virtual reality (VR) technology can help reduce stress and improve mood. VR uses computer technology to make fake experiences and environments that look real. This allows people to escape from their lives and experience more positive thoughts and emotions. Objective: To learn if it is feasible to use a VR relaxation intervention in people with PBTs. Eligibility: Adults 18 and older who have a brain tumor and have recently reported psychological distress during their participation in the Natural History Study (NHS), protocol #16C0151 Design: The VR intervention and all patient-reported outcome measures (PROs) will be done remotely using telehealth. Participants will be mailed a VR headset. This headset looks like a thick pair of goggles that is worn over the eyes. Participants will view computer-generated environments on this VR headset. Participants will fill out symptoms questionnaires at 4 different times points during participation in this study, including questionnaires for the NHS as well as 4 questionnaires unique to this study. There are also optional saliva samples collected at these timepoints. The 4 timepoints are: - Before the VR intervention - After the VR intervention - 1 week later - 4 weeks later Participants will also have a phone interview 1 week after the initial VR interevention, which will last 10 to 15 minutes. Participation lasts 4 to 6 weeks. Type: Interventional Start Date: Mar 2021 |
Psilocybin Therapy for Depression in Parkinson's Disease
Joshua Woolley, MD, PhD
Parkinson Disease
Depression
The purpose of this study is to understand whether people with Parkinson's Disease and
depression have improvement in their symptoms after psilocybin therapy. expand
The purpose of this study is to understand whether people with Parkinson's Disease and depression have improvement in their symptoms after psilocybin therapy. Type: Interventional Start Date: Aug 2024 |
Fasedienol Nasal Spray for the Acute Treatment of Anxiety in Adults With Social Anxiety Disorder (PALISADE-3)
VistaGen Therapeutics, Inc.
Social Anxiety Disorder
This U.S. Phase 3 clinical trial is designed to evaluate the efficacy, safety, and
tolerability of the acute intranasal (i.n.) administration of Fasedienol Nasal Spray
(fasedienol) (3.2 µg) to relieve symptoms of acute anxiety in adult subjects ages 18
through 65 with Social Anxiety Disorder induced... expand
This U.S. Phase 3 clinical trial is designed to evaluate the efficacy, safety, and tolerability of the acute intranasal (i.n.) administration of Fasedienol Nasal Spray (fasedienol) (3.2 µg) to relieve symptoms of acute anxiety in adult subjects ages 18 through 65 with Social Anxiety Disorder induced by a public speaking challenge (PSC) in a clinical setting. In addition, safety and tolerability of i.n. administration of 3.2 µg of fasedienol, as-needed, up to 6 times per day for up to 12 months, will be assessed in those subjects who complete PALISADE-3 and choose to enter the distinct open-label extension phase of the study. Type: Interventional Start Date: Mar 2024 |
Diet and Depression
University of California, San Francisco
Depression
Major Depressive Disorder
Weight Gain
Obesity
Metabolic Syndrome
This study is a pilot open label crossover trial to assess the feasibility and
acceptability of reducing ultra- processed foods (UPF) in a personalized manner from the
diets of patients with major depressive disorder who eat a large percentage of UPF. expand
This study is a pilot open label crossover trial to assess the feasibility and acceptability of reducing ultra- processed foods (UPF) in a personalized manner from the diets of patients with major depressive disorder who eat a large percentage of UPF. Type: Interventional Start Date: Jun 2024 |
Type I Hybrid Effectiveness-Implementation Trial of Primary Care Brief Mindfulness Training for Veterans
VA Office of Research and Development
Post Traumatic Stress Disorder (PTSD)
Depression
Anxiety
The VA wants to understand what type of integrative and whole health approaches are
helpful for Veterans. The study is comparing two primary care based mental health
treatments, a mindfulness class that teaches mindfulness meditation and a problem-solving
class that teaches problem-solving skills... expand
The VA wants to understand what type of integrative and whole health approaches are helpful for Veterans. The study is comparing two primary care based mental health treatments, a mindfulness class that teaches mindfulness meditation and a problem-solving class that teaches problem-solving skills and how to build resilience, for Veterans who are experiencing symptoms of anxiety, depression, and/or PTSD. The goal of the study is to understand if the classes reduce symptoms of anxiety, depression, and/or PTSD and increase overall functioning. Type: Interventional Start Date: Aug 2024 |
Effect of Vagal Nerve Stimulation on Gastric Motor Functions
Mayo Clinic
Epilepsy
Depression
The specific aim of this study is to compare simultaneous assessment of gastric emptying
and gastric accommodation in response to the same caloric meal before and three months
after activation of left cervical VNS. Our hypothesis is that cervical VNS increases
gastric accommodation and accelerates... expand
The specific aim of this study is to compare simultaneous assessment of gastric emptying and gastric accommodation in response to the same caloric meal before and three months after activation of left cervical VNS. Our hypothesis is that cervical VNS increases gastric accommodation and accelerates gastric emptying. Type: Interventional Start Date: Sep 2024 |
Center M: Digital Health Innovation Pilot
Oregon Health and Science University
Perinatal Depression
Center M is a digital health solution to Perinatal Depression (PD) which provides an
alternative to Mindfulness Based Cognitive Therapy - Perinatal Depression (MBCT-PD).
Center M shifts treatment to a telehealth model, reduces the number of sessions, and
transitions home practice materials to a digital... expand
Center M is a digital health solution to Perinatal Depression (PD) which provides an alternative to Mindfulness Based Cognitive Therapy - Perinatal Depression (MBCT-PD). Center M shifts treatment to a telehealth model, reduces the number of sessions, and transitions home practice materials to a digital format. This study will include a clinical trial in which participants will be randomized to the Center M treatment with smartphone app delivery of homework compared to treatment as usual (TAU). Type: Interventional Start Date: Feb 2024 |
Implementation of Collaborative Care for Depression in VA HIV Clinics
VA Office of Research and Development
HIV
Depression
HIV Translating Initiatives for Depression into Effective Solutions (HITIDES) is a
team-based service to manage depression in Veterans Living with HIV (VLWH). This service
is more effective for managing depression than the care VLWH usually receive and saves
resources. HITIDES is also liked by HIV... expand
HIV Translating Initiatives for Depression into Effective Solutions (HITIDES) is a team-based service to manage depression in Veterans Living with HIV (VLWH). This service is more effective for managing depression than the care VLWH usually receive and saves resources. HITIDES is also liked by HIV care providers and VLWH. Despite this, no VA clinics currently offer this service. This study examines two approaches to engage clinics with HITIDES, the resulting effects on VLWH, and the costs of these approaches. The first approach includes recruiting an HIV care provider at the site to help connect with the service and a network of providers to support this person. The second approach uses an additional external expert to facilitate these connections. Understanding how to connect Veterans to the HITIDES service will allow VA to improve depression care for VLWH and save VA resources. Type: Interventional Start Date: Aug 2024 |
Depressed Mood Improvement Through Nicotine Dosing-3 (Depressed MIND3) Extension
Vanderbilt University Medical Center
Depressive Disorder
Deficits in cognitive control are core features of late-life depression (LLD),
contributing both to emotion dysregulation and problems with inhibiting irrelevant
information, conflict detection, and working memory. Clinically characterized as
executive dysfunction, these deficits are associated with... expand
Deficits in cognitive control are core features of late-life depression (LLD), contributing both to emotion dysregulation and problems with inhibiting irrelevant information, conflict detection, and working memory. Clinically characterized as executive dysfunction, these deficits are associated with poor response to antidepressants and higher levels of disability. Improvement of cognitive control network (CCN) dysfunction may benefit both mood and cognitive performance, however no current pharmacotherapy improves Cognitive Control Network deficits in LLD. The study examines the hypothesis that nicotine acetylcholine receptor agonists enhance Cognitive Control Network function. This effect may resultantly improve mood and cognitive performance in LLD. Small, open-label studies of transdermal nicotine (TDN) patches have supported potential clinical benefit and provided support that transdermal nicotine administration engages the Cognitive Control Network. This is an open-label, extension to the blinded Depressed MIND 3 (Depressed Mood Improvement through nicotine dosing) study. It will evaluate longer-term safety and efficacy of Transdermal Nicotine Patches for potential benefit in cognitive and depression outcomes in elderly depressed participants. Subjects complete blinded randomized trial of Depressed MIND-3 will be eligible for continuation in this extension. This extension study will consist of up to 12 weeks of treatment and a 3 -week safety follow-up period. Type: Interventional Start Date: Apr 2023 |
A Clinical Trial of Tolcapone in Obsessive Compulsive Disorder
University of Chicago
Obsessive-Compulsive Disorder
OCD
The primary aim of the present study is to examine the efficacy and safety of tolcapone
in adults with moderate to severe OCD. expand
The primary aim of the present study is to examine the efficacy and safety of tolcapone in adults with moderate to severe OCD. Type: Interventional Start Date: Jun 2023 |
Repurposing Low-Dose Clonidine for PTSD in Veterans
Aurora Health Care
PTSD
Posttraumatic Stress Disorder
Sleep
Hypothesis: Veterans with PTSD prescribed clonidine will demonstrate improvements in PTSD
symptoms, including daytime, nighttime, and sleep-related behaviors. expand
Hypothesis: Veterans with PTSD prescribed clonidine will demonstrate improvements in PTSD symptoms, including daytime, nighttime, and sleep-related behaviors. Type: Interventional Start Date: Jun 2023 |
Early Intervention for Youth at High Risk for Bipolar Disorder
University of Pittsburgh
Bipolar Disorder
Investigators will conduct a confirmatory efficacy trial of Interpersonal and Social
Rhythm Therapy (IPSRT) delivered via telehealth for offspring of bipolar parents (OBP;
age 12-18, n=120) at elevated risk for BP onset via risk calculator score. All
participants receive a baseline clinical assessment... expand
Investigators will conduct a confirmatory efficacy trial of Interpersonal and Social Rhythm Therapy (IPSRT) delivered via telehealth for offspring of bipolar parents (OBP; age 12-18, n=120) at elevated risk for BP onset via risk calculator score. All participants receive a baseline clinical assessment of psychiatric symptoms and sleep disturbance (via objective and subjective methods), followed by a feedback session. Youth are then randomized to receive 8 sessions of IPSRT or a manualized Healthy Lifestyle Behaviors Program (HL) delivered via secure videoconference. As clinically indicated, youth are offered Community Treatment Referral (CTR) for any psychiatric symptoms/disorders identified at intake. Primary outcome domains over 18 months include mania and affective lability. Investigators will also further investigate the hypothesized mechanism underlying IPSRT (i.e., sleep/circadian disruption) across levels of analysis, and the contribution of interpersonal stress to sleep/circadian disruptions. Application of Implementation Science methods throughout maximizes ultimate scalability and feasibility if efficacious. Investigators will also examine whether passive cellphone sensing may serve as a portable, cost-effective measure of mechanisms and outcomes to enhance ultimate dissemination. Type: Interventional Start Date: Sep 2021 |
Meditation Accelerated Brain Stimulation for Depression
University of California, San Diego
Depression
Repetitive Transcranial magnetic stimulation (rTMS) is an FDA-approved treatment for
depression that involves brief magnetic stimulation pulses on the dorsolateral prefrontal
cortex (DLPFC) brain region. The ultimate goal of this treatment is to increase
excitability and long-term plasticity in DLPFC,... expand
Repetitive Transcranial magnetic stimulation (rTMS) is an FDA-approved treatment for depression that involves brief magnetic stimulation pulses on the dorsolateral prefrontal cortex (DLPFC) brain region. The ultimate goal of this treatment is to increase excitability and long-term plasticity in DLPFC, a brain region shown to be hypo-active in depression. Unfortunately, rTMS only has low to moderate efficacy; remission rates for patients range from ~15-30% in large randomized controlled trials. The focus of this research is to develop a next-generation rTMS protocol that is guided by the basic principles underlying brain plasticity, in order to improve the efficacy of rTMS for the treatment of depression. Specifically, in this study the investigators will test rTMS paired with a depression-relevant cognitive state of internal attention. Type: Interventional Start Date: Jul 2021 |
Acute and Long-Term Antidepressant Treatment Success in Adolescents With Anxiety (AtLAS-A)
University of Cincinnati
Anxiety
Depressive Symptoms
Acute, double-blind, adaptively randomized treatment with duloxetine or escitalopram,
followed by open-label naturalistic follow-up. expand
Acute, double-blind, adaptively randomized treatment with duloxetine or escitalopram, followed by open-label naturalistic follow-up. Type: Interventional Start Date: Jan 2020 |
Estrogen and Fear in PTSD
NYU Langone Health
PTSD
The purpose of this research study is to determine if taking a pill of estradiol (E2)
together with prolonged exposure (PE) therapy can improve this treatment outcome in women
diagnosed with Post-Traumatic Stress Disorder (PTSD). 80 subjects will take part in this
research study across NYU Langone... expand
The purpose of this research study is to determine if taking a pill of estradiol (E2) together with prolonged exposure (PE) therapy can improve this treatment outcome in women diagnosed with Post-Traumatic Stress Disorder (PTSD). 80 subjects will take part in this research study across NYU Langone Health and UPenn (40 subjects at each site). Participants will be randomized into one of two groups, PE + E2 or PE + placebo. The study will include preliminary screening and baseline visits, experimental visits, and therapy visits over the course of six weeks. Several follow-up visits will take place. Type: Interventional Start Date: Jun 2020 |
- Previous
- Next