Search Clinical Trials
Before medications are approved by the U.S. Food and Drug Administration (FDA) or before certain therapy methods are widely accepted as effective, they are tested on people who volunteer to participate in a clinical trial.
Organizations across the country are looking for people like you to take part in their research studies. The list of studies below have been selected from ClinicalTrials.gov based on their inclusion of one or more of the following terms: anxiety disorders, depression, OCD, PTSD, and bipolar disorder.
The Anxiety and Depression Association of America (ADAA) is supportive of research that is conducted through clinical trials. Participating in research can potentially help change the mental health outcomes for you and others who suffer anxiety, depression, and related disorders. You may learn about new interventions/treatments that are being considered.
Read this ADAA blog about things to know and questions to ask before committing to a clinical trial.
This website page is brought to you in partnership with ResearchMatch.
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The Development of PATH, a Program to Support NICU Parent Mental Health Through the Transition From Hospital...
University of Colorado, Denver
Perinatal Depression
Perinatal Anxiety
Post Traumatic Stress Disorder
The objective of this study is to develop and pilot test a telehealth-based mental health
screening and engagement program that supports parents as they transition from the NICU
to home. The program will use a stepped-care approach to screen parents for depression,
anxiety, and PTSD; provide a brief... expand
The objective of this study is to develop and pilot test a telehealth-based mental health screening and engagement program that supports parents as they transition from the NICU to home. The program will use a stepped-care approach to screen parents for depression, anxiety, and PTSD; provide a brief behavioral intervention to those who screen as having at least a low risk of these conditions; and provide a warm hand-off to community mental health services for those at medium to high risk. Type: Interventional Start Date: Jun 2024 |
Improving Psychological Outcomes for Acute Respiratory Failure Survivors Using a Self-Management Intervention
Johns Hopkins University
Respiratory Failure
Anxiety
Critical Illness
A growing number of patients are surviving a stay in the intensive care unit (ICU) but
may experience long-lasting psychological problems, but research evaluating such
treatment for ICU patients is scant.
The goal of this pilot randomized controlled trial is to evaluate the feasibility,
acceptability,... expand
A growing number of patients are surviving a stay in the intensive care unit (ICU) but may experience long-lasting psychological problems, but research evaluating such treatment for ICU patients is scant. The goal of this pilot randomized controlled trial is to evaluate the feasibility, acceptability, and potential benefit of an evidence-based psychological intervention for anxiety and associated outcomes for ICU patients. The main question[s] it aims to answer are: - Is this intervention feasible and acceptable in ARF patients? - Is this intervention in the ICU and hospital associated with reduced anxiety symptoms? Participants will participate in a cognitive behavioral therapy informed self-management intervention aimed to reduce anxiety symptoms. Researchers will compare the intervention group to patients who receive usual care to see if the intervention reduces symptoms at the the conclusion of the intervention and at 3 months follow-up. Type: Interventional Start Date: May 2024 |
Impact of Bluetooth Haptics Device Distraction on Mechanical Pain Thresholds Induced by PinPrick Stimulators
Stanford University
Pain
Anxiety
This is a prospective, crossover study of healthy participants evaluating the mechanical
pain threshold for weighted pinprick stimuli. expand
This is a prospective, crossover study of healthy participants evaluating the mechanical pain threshold for weighted pinprick stimuli. Type: Interventional Start Date: Jun 2024 |
Hybrid Type 1 Randomized Pilot Trial of a Peer-led Family and Social Strengthening Group Intervention...
University of Illinois at Chicago
Depression
Anxiety
PTSD
Family Dynamics
Social Functioning
The proposed study draws on prior research to evaluate the feasibility, acceptability and
explore preliminary effectiveness of Coffee and Family Education and Support, Version
(CAFES2) using a pilot randomized type 1 hybrid effectiveness-implementation design.
CAFES2 is a peer-led family and social... expand
The proposed study draws on prior research to evaluate the feasibility, acceptability and explore preliminary effectiveness of Coffee and Family Education and Support, Version (CAFES2) using a pilot randomized type 1 hybrid effectiveness-implementation design. CAFES2 is a peer-led family and social strengthening multiple family group intervention that is designed to respond to multi-level needs of refugee families. Results of the trial will contribute to the emerging evidence base on family-based mental health interventions for refugee and newcomer communities. The trial will also generate new insights regarding implementation strategies needed to promote successful delivery of services by peer providers and the unique role of human-centered design practices for adaptation of mental health and psychosocial interventions. Type: Interventional Start Date: May 2024 |
Brief Cognitive Behavioral Therapy to Enhance Benzodiazepine Deprescribing
Beth Israel Deaconess Medical Center
Benzodiazepine Use
Insomnia
Anxiety
The goal of this clinical trial is to conduct a single-arm pilot trial of a brief
cognitive-behavioral therapy-enhanced benzodiazepine deprescribing intervention in 20
older adults (aged ≥55 years) prescribed chronic benzodiazepines by their primary care
clinicians. expand
The goal of this clinical trial is to conduct a single-arm pilot trial of a brief cognitive-behavioral therapy-enhanced benzodiazepine deprescribing intervention in 20 older adults (aged ≥55 years) prescribed chronic benzodiazepines by their primary care clinicians. Type: Interventional Start Date: Nov 2023 |
taVNS on the Inpatient Psychiatric Unit
Medical University of South Carolina
Depression, Anxiety
This is a research study to find out if mental health symptoms in patients admitted to
the Institute of Psychiatry are affected by a form of ear stimulation called
transcutaneous auricular vagus nerve stimulation, or taVNS. Participants will receive ear
stimulation during their inpatient treatment... expand
This is a research study to find out if mental health symptoms in patients admitted to the Institute of Psychiatry are affected by a form of ear stimulation called transcutaneous auricular vagus nerve stimulation, or taVNS. Participants will receive ear stimulation during their inpatient treatment at the Institute of Psychiatry. Participants will be randomly assigned to either receive ear stimulation for 1 day (up to 9 treatments over the course of a single day) or 3 days (up to 3 treatments per day), and will have a 50:50 chance of being in either group (like the flip of a coin). Each treatment will last up to 30 minutes and there will be a break of at least 30 minutes in between treatments. The study team will ask participants to complete a group of questionnaires at the beginning and end of the study. In addition, there are several questionnaires that will be completed daily while participants are receiving ear stimulation. Participants in the 1 day stimulation group will also receive 2 days of follow up questionnaires after the initial day of stimulation. The questionnaires will ask questions about mental health symptoms that subjects may or may not be experiencing, including questions about mood, anxiety, and sleep. The ear stimulation treatments will not interfere with the care subjects are receiving from the medical team. In order to qualify for this study, participants must be actively receiving inpatient care at the MUSC Institute of Psychiatry. Type: Interventional Start Date: Dec 2022 |
Mood Lifters for Undergraduates
University of Michigan
Depression
Anxiety
Mood Disorders
Mental Health Wellness 1
Stress
Large-scale, effective, low-cost, and evidence-based programs that can nimbly translate
new research discoveries into prevention and care for psychosocial-based problems are
urgently needed since the vast majority of people who need evidence-based care do not
receive it.
The purpose of this randomized... expand
Large-scale, effective, low-cost, and evidence-based programs that can nimbly translate new research discoveries into prevention and care for psychosocial-based problems are urgently needed since the vast majority of people who need evidence-based care do not receive it. The purpose of this randomized control trial is to investigate the feasibility and efficacy of a Mood Lifters group template specifically for undergraduate students. Mood Lifters is an effective peer-led program that improves or maintains mental health. It seeks to help people enhance pleasure, engagement, and meaning in their lives while minimizing depression, fear, loneliness, and other negative feelings via a proprietary peer-based program that offers weekly meetings and other flexible support options. One obstacle to providing mental health care in the US is that it is costly to provide one-on-one therapy by a licensed professional. This is particularly true in large group settings with limited resources (counseling centers) and a large need for mental health care, like universities. Type: Interventional Start Date: Aug 2023 |
Virtual Reality (VR) for Prone Pain Procedures
University of California, Davis
Virtual Reality
Anxiety
Pain
The purpose of this study is to evaluate the effectiveness of virtual reality (VR)
distraction in patients undergoing interventional pain procedures in the prone position.
VR has been shown to improve patient experience during interventional pain procedures,
however, many of these procedures are done... expand
The purpose of this study is to evaluate the effectiveness of virtual reality (VR) distraction in patients undergoing interventional pain procedures in the prone position. VR has been shown to improve patient experience during interventional pain procedures, however, many of these procedures are done in the prone position making VR a challenge. This study will evaluate the effect of a VR headset and support in patients undergoing prone interventional pain procedures compared to control. Type: Interventional Start Date: May 2024 |
Music Interventions During Wide-Awake Hand Surgery
University of Wisconsin, Madison
Anxiety
Surgery
The purpose of this study is to examine if patients have a lower anxiety level during
wide awake hand surgery while listening to their choice of music vs standardized
relaxation music. Patients who are planning to undergo wide awake (local anesthetic only
hand surgery) and agree to participate will... expand
The purpose of this study is to examine if patients have a lower anxiety level during wide awake hand surgery while listening to their choice of music vs standardized relaxation music. Patients who are planning to undergo wide awake (local anesthetic only hand surgery) and agree to participate will be randomized to either a music intervention where they listen to their choice of music genre or standardized relaxation music during their time in the operating room. 170 participants will be enrolled and can expect to be on study for 2 weeks. Type: Interventional Start Date: Dec 2024 |
The DC Mother-Infant Behavioral Wellness Program
Children's National Research Institute
Perinatal Depression
Perinatal Anxiety
Prenatal Stress
This randomized controlled study will examine the effectiveness of patient navigation
with culturally adapted cognitive-behavioral interventions and peer support groups for
low-income Black/of African Descent pregnant women who are experiencing stress, anxiety,
and/or depression. expand
This randomized controlled study will examine the effectiveness of patient navigation with culturally adapted cognitive-behavioral interventions and peer support groups for low-income Black/of African Descent pregnant women who are experiencing stress, anxiety, and/or depression. Type: Interventional Start Date: Aug 2022 |
A Primary Care-Based Psychosocial Intervention To Improve Cognitive & Depression Outcomes in Older Adults...
Weill Medical College of Cornell University
Depression
Pain
Cognitive Impairment
The purpose of the study is to examine the effect of Problem Adaptation Therapy for Pain
(PATH-Pain) on cognitive functioning, depression and pain-related disability in 100 older
adults with cognitive impairment, chronic pain, and depression. The study will test if
PATH-Pain has better cognitive,... expand
The purpose of the study is to examine the effect of Problem Adaptation Therapy for Pain (PATH-Pain) on cognitive functioning, depression and pain-related disability in 100 older adults with cognitive impairment, chronic pain, and depression. The study will test if PATH-Pain has better cognitive, affective, and functional outcomes than Attention Control Usual Care. Type: Interventional Start Date: Jun 2022 |
Personalized DBS for OCD Guided by Stereoencephalography Mapping
Andrew Moses Lee, MD, PhD
Obsessive-Compulsive Disorder
OCD
This is a double-blinded, randomized, crossover study design for SEEG-guided 4-lead DBS
for treatment-refractory OCD, followed by open label stimulation for an additional 6
months. The study will be conducted in 3 stages: Stage 1 will consist of SEEG brain
mapping and optimization of stimulation parameters.... expand
This is a double-blinded, randomized, crossover study design for SEEG-guided 4-lead DBS for treatment-refractory OCD, followed by open label stimulation for an additional 6 months. The study will be conducted in 3 stages: Stage 1 will consist of SEEG brain mapping and optimization of stimulation parameters. Stage 2 will consist of 4-lead DBS surgery with bilateral IPGs and further optimization of stimulation parameters. Stage 3 will be randomized, crossover treatment, followed by open label treatment. Type: Interventional Start Date: May 2024 |
Enhancing Purpose and Well-Being Through a Volunteering Experience Connecting Veterans With English Language...
University of Michigan
Depression
Anxiety
Post Traumatic Stress Disorder
The goal of this study is to refine and test a strategy for engaging Veterans with
symptoms of depression, anxiety, and/or PTSD (Post Traumatic Stress Disorder) as
volunteers to help English language learners (ELLs) improve their speaking skills via
structured conversations using videoconferencing. expand
The goal of this study is to refine and test a strategy for engaging Veterans with symptoms of depression, anxiety, and/or PTSD (Post Traumatic Stress Disorder) as volunteers to help English language learners (ELLs) improve their speaking skills via structured conversations using videoconferencing. Type: Interventional Start Date: Apr 2024 |
Postpartum Video Education in High Risk Populations
Weill Medical College of Cornell University
Postpartum Hemorrhage
Postpartum Depression
Postpartum Sepsis
Postpartum Preeclampsia
Patient Empowerment
This is a prospective, single-center, randomized control study to determine if video
education at the time of postpartum discharge improves patient knowledge on the warning
signs for the top three causes of severe maternal morbidity (infection, hemorrhage, and
blood pressure disorders) in the first... expand
This is a prospective, single-center, randomized control study to determine if video education at the time of postpartum discharge improves patient knowledge on the warning signs for the top three causes of severe maternal morbidity (infection, hemorrhage, and blood pressure disorders) in the first seven days following delivery for self-identified, Black, Latinx, other with two or more self-identified races, Medicaid, and/or uninsured postpartum individuals. Participants will be randomized to written discharge education + video education (intervention) vs standard discharge education (control). They will complete a baseline questionnaire and a post-discharge education questionnaire during their postpartum stay to assess for knowledge improvement. The investigators hypothesize that video education will improve patient's knowledge of severe maternal morbidity warning signs. Type: Interventional Start Date: May 2024 |
Cannabidiol and Older Adult Cannabis Users
University of Colorado, Boulder
Sleep
Anxiety
Depression
Pain
Cannabis use increased 10 fold among adults over the age of 65 between 2014 and 2016 but
very little data exists on the extent of their harmful effects on health and behavior.
The overarching goal of this project is to test a novel harm reduction strategy in which
older individuals who seek to use... expand
Cannabis use increased 10 fold among adults over the age of 65 between 2014 and 2016 but very little data exists on the extent of their harmful effects on health and behavior. The overarching goal of this project is to test a novel harm reduction strategy in which older individuals who seek to use cannabis for pain, anxiety or mood problems (depression/anxiety) will be randomly assigned to one of three conditions in an 8 week randomized controlled trial: hemp-derived CBD+THC, hemp-derived CBD-THC, or placebo. This work has the ability to directly inform individual choices regarding the use of cannabis products among older adults, and direct policy decisions regulating cannabis formulations on the legal market. Type: Interventional Start Date: May 2024 |
Cold and Heat Investigation to Lower Levels of Depression
Vail Health Behavioral Health
Depression
Mood Disorders
This study will recruit 112 medically healthy adults (aged 18-65) currently experiencing
depressive symptoms to be randomized to receive either a single Whole Body Hyperthermia
(heat therapy) treatment or a Whole Body Hyperthermia treatment followed by a cold water
plunge. Participants will complete... expand
This study will recruit 112 medically healthy adults (aged 18-65) currently experiencing depressive symptoms to be randomized to receive either a single Whole Body Hyperthermia (heat therapy) treatment or a Whole Body Hyperthermia treatment followed by a cold water plunge. Participants will complete a baseline assessment of their depressive symptoms as well as 1-week and 2-week post-treatment followup assessments. Type: Interventional Start Date: May 2024 |
Peer-led Trauma Therapy for Re-entry
University of Wisconsin, Madison
PTSD
The purpose of the research is to learn more about how to treat PTSD for people directly
impacted by incarceration (i.e., have spent time in prison or jail). This research will
help identify if a PTSD treatment group that is used in community settings, and led by
individuals with lived experience,... expand
The purpose of the research is to learn more about how to treat PTSD for people directly impacted by incarceration (i.e., have spent time in prison or jail). This research will help identify if a PTSD treatment group that is used in community settings, and led by individuals with lived experience, is helpful in reducing PTSD symptoms among people who have been directly impacted by incarceration. Participants will complete an interview to determine whether they are experiencing PTSD, and if so, will participate in a 6-week therapy group treatment. Type: Interventional Start Date: Nov 2023 |
Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality
Weill Medical College of Cornell University
Depression
Suicidal Ideation
Major Depressive Disorder
Depressive Disorder
The investigators hypothesized that during the 9-week course of Engage & Connect
treatment there will be an increase in brain functions of the Positive Valence System
which in turn will lead to reduction in suicidality. expand
The investigators hypothesized that during the 9-week course of Engage & Connect treatment there will be an increase in brain functions of the Positive Valence System which in turn will lead to reduction in suicidality. Type: Interventional Start Date: Sep 2023 |
Amygdala Neurofeedback for Depression - Large Scale Clinical Trial
University of Pittsburgh
Major Depressive Disorder
The goal of this study is to evaluate whether rtfMRI-nf training to increase the amygdala
response to positive memories may serve as a stand-alone intervention for major
depressive disorder expand
The goal of this study is to evaluate whether rtfMRI-nf training to increase the amygdala response to positive memories may serve as a stand-alone intervention for major depressive disorder Type: Interventional Start Date: Jun 2023 |
Psilocybin for the Treatment of Veterans With Post-Traumatic Stress Disorder
Ohio State University
PTSD
Stress Disorders, Traumatic
Stress Disorders, Post-Traumatic
Trauma and Stressor Related Disorders
Mental Disorder
The primary aim of this study is to assess the safety and efficacy of psilocybin-assisted
therapy in the treatment of post-traumatic stress disorder in United States military
Veterans. expand
The primary aim of this study is to assess the safety and efficacy of psilocybin-assisted therapy in the treatment of post-traumatic stress disorder in United States military Veterans. Type: Interventional Start Date: Jan 2023 |
Trial of Centanafadine Efficacy and Safety as Monotherapy or as Adjunct to SSRI in Adults With Major...
Otsuka Pharmaceutical Development & Commercialization, Inc.
Major Depressive Disorder
This is a phase 2, multicenter, randomized, double-blind, placebo-controlled,
parallel-arm trial to assess the efficacy, safety, and tolerability of centanafadine
once-daily (QD) extended-release (XR) capsules for the treatment of adult subjects
diagnosed with Major Depressive Disorder (MDD).
The... expand
This is a phase 2, multicenter, randomized, double-blind, placebo-controlled, parallel-arm trial to assess the efficacy, safety, and tolerability of centanafadine once-daily (QD) extended-release (XR) capsules for the treatment of adult subjects diagnosed with Major Depressive Disorder (MDD). The trial will evaluate the efficacy and safety of centanafadine QD XR capsules as monotherapy or as adjunct to the selective serotonin reuptake inhibitor (SSRI), escitalopram. Type: Interventional Start Date: Sep 2022 |
Targeting Specific Brain Networks to Treat Specific Symptoms in Depression
Massachusetts General Hospital
Major Depressive Disorder
Repetitive transcranial magnetic stimulation (rTMS) is a way of non-invasively
stimulating specific brain networks and is an established treatment for Major Depressive
Disorder (MDD). This proposal will reveal network mechanisms of the therapeutic effects
of rTMS by investigating how stimulating each... expand
Repetitive transcranial magnetic stimulation (rTMS) is a way of non-invasively stimulating specific brain networks and is an established treatment for Major Depressive Disorder (MDD). This proposal will reveal network mechanisms of the therapeutic effects of rTMS by investigating how stimulating each network specifically changes network connectivity and behavior. This will be done in a highly individualized manner in depressed and healthy patients, leading to more effective and more individualized treatments for depression. Type: Interventional Start Date: Mar 2024 |
Digital CBT for Insomnia and Depression
University of Rochester
Depression
Insomnia
This study has two primary objectives, each of which addresses critical clinical and
research gaps for individuals who have co-occurring insomnia and depression. The first
objective is to address whether sequential treatment of insomnia and depression is
superior to a single treatment for either depression... expand
This study has two primary objectives, each of which addresses critical clinical and research gaps for individuals who have co-occurring insomnia and depression. The first objective is to address whether sequential treatment of insomnia and depression is superior to a single treatment for either depression or for insomnia, and if so, which treatment sequence is optimal. The second objective is to determine if there are heterogeneity of treatment effects; that is, variation in which interventions are best for which individuals, and if so, to develop and individualized intervention rule to better match individuals with the treatment that is most likely to lead to the best outcomes. A large randomized trial will be conducted to meet these objectives. Type: Interventional Start Date: May 2023 |
Community Reinforcement and Family Training for Early Psychosis (CRAFT-EP) and Substance Use: A Pilot...
Mclean Hospital
Psychosis
Substance Use
Substance Use Disorders
Family
Cannabis
The purpose of this study is to evaluate Community Reinforcement and Family Training for
Early Psychosis (CRAFT-EP) for families experiencing early psychosis and substance use
delivered exclusively or primarily via telehealth (video conferencing). expand
The purpose of this study is to evaluate Community Reinforcement and Family Training for Early Psychosis (CRAFT-EP) for families experiencing early psychosis and substance use delivered exclusively or primarily via telehealth (video conferencing). Type: Interventional Start Date: May 2022 |
Elucidating the Neurocircuitry of Irritability With High-Field Neuroimaging to Identify Novel Therapeutic...
University of Texas Southwestern Medical Center
Major Depressive Disorder
Healthy Controls
The study is investigating dysfunctions in neurocircuitry in regards to irritability with
healthy controls (HC) and individuals with Major Depressive Disorder (MDD) by performing
MRIs. The MDD group will also be randomized to receive ketamine or midazolam to
investigate changes post-treatment in neurocircuitry... expand
The study is investigating dysfunctions in neurocircuitry in regards to irritability with healthy controls (HC) and individuals with Major Depressive Disorder (MDD) by performing MRIs. The MDD group will also be randomized to receive ketamine or midazolam to investigate changes post-treatment in neurocircuitry with regards to irritability. Type: Interventional Start Date: May 2022 |
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