Search Clinical Trials
Before medications are approved by the U.S. Food and Drug Administration (FDA) or before certain therapy methods are widely accepted as effective, they are tested on people who volunteer to participate in a clinical trial.
Organizations across the country are looking for people like you to take part in their research studies. The list of studies below have been selected from ClinicalTrials.gov based on their inclusion of one or more of the following terms: anxiety disorders, depression, OCD, PTSD, and bipolar disorder.
The Anxiety and Depression Association of America (ADAA) is supportive of research that is conducted through clinical trials. Participating in research can potentially help change the mental health outcomes for you and others who suffer anxiety, depression, and related disorders. You may learn about new interventions/treatments that are being considered.
Read this ADAA blog about things to know and questions to ask before committing to a clinical trial.
This website page is brought to you in partnership with ResearchMatch.
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Cannabidiol as a Treatment for Social Anxiety Disorder (R61)
NYU Langone Health
Social Anxiety Disorder
The R61 will include two CBD dose levels vs placebo (PBO) and examine potential
engagement with two primary targets in a 3-week randomized controlled trial design.
Willing and eligible subjects will be randomized to one of three randomized double-blind
treatments (n = 20 each group): 1) CBD 800 mg1 expand
The R61 will include two CBD dose levels vs placebo (PBO) and examine potential engagement with two primary targets in a 3-week randomized controlled trial design. Willing and eligible subjects will be randomized to one of three randomized double-blind treatments (n = 20 each group): 1) CBD 800 mg (400 mg twice daily), 2) CBD 400 mg (200 mg twice daily), or 3) PBO twice daily for three weeks. Participation is estimated at approximately 1 month from end of screening to endpoint for the primary R61 study period. This includes screening, baseline, week 2 stress task, Week 3 2-day imaging paradigm, and clinical safety assessments at weeks 2 and 3. Type: Interventional Start Date: Jan 2023 |
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Smart-Phone Safety Behavior Fading Intervention for Appearance Concerns (Open ARSB Study)
Florida State University
Body Dysmorphic Disorder
Social Anxiety Disorder
Eating Disorders
The current study aims to explore the efficacy of a text message based safety behavior
fading intervention compared to a relaxing video intervention for appearance concerns. expand
The current study aims to explore the efficacy of a text message based safety behavior fading intervention compared to a relaxing video intervention for appearance concerns. Type: Interventional Start Date: Apr 2025 |
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Feasibility of Virtual, Tailored, Music-Based Relaxation for Anxiety in Adolescent and Young Adult1
University of Michigan Rogel Cancer Center
Anxiety
Demonstrate the feasibility of conducting an eight-week, (45 min/week), theory driven,
virtually-delivered, tailored music-based relaxation (TiMBRe) intervention to decrease
anxiety in adolescent and young adult (AYA) cancer survivors with clinically-relevant
anxiety. expand
Demonstrate the feasibility of conducting an eight-week, (45 min/week), theory driven, virtually-delivered, tailored music-based relaxation (TiMBRe) intervention to decrease anxiety in adolescent and young adult (AYA) cancer survivors with clinically-relevant anxiety. Type: Interventional Start Date: Jan 2025 |
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[18F]PF-06445974 to Image PDE4B in Major Depressive Disorder Using PET
National Institute of Mental Health (NIMH)
Depression
Background:
Major depressive disorder (MDD) is a psychiatric condition. People with MDD have
occasional bouts of depressive symptoms; these bouts are called major depressive episodes
(MDEs). Researchers want to know if people having MDEs have lower levels of an enzyme
called PDE4B in their brains.1 expand
Background: Major depressive disorder (MDD) is a psychiatric condition. People with MDD have occasional bouts of depressive symptoms; these bouts are called major depressive episodes (MDEs). Researchers want to know if people having MDEs have lower levels of an enzyme called PDE4B in their brains. Primary Objective: To determine whether PDE4B is reduced in the brains of individuals with MDD experiencing a major depressive episode (MDE). Secondary Objectives: To determine the optimal length of scanning and the retest variability and reliability of [18F]PF-06445974, and whether PDE4B binding correlates with clinical rating scales. To measure if PDE4B radioligand binding can be blocked by taking apremilast. Eligibility: People aged 18-70 years with MDD. Healthy volunteers are also needed. Design: Participants will have up to 5 clinic visits. Participants will be screened. They will have a physical exam with blood tests. They will have a test of their heart function. Some participants may have a psychiatric assessment; they will answer questions about their state of mind and related topics. Participants will have magnetic resonance imaging (MRI) of the brain. They will lie on a table that slides into a metal cylinder. Participants will have a positron emission tomography (PET) scan. A needle will be used to guide a thin plastic tube (catheter) into a vein in one arm. An experimental substance called a radioactive tracer ([18F]PF-06445974) will be injected through the catheter. Participants will lie on a table that slides into a doughnut-shaped machine. The scan will last up to 4 hours with a 15-minute break. Participants blood pressure, heart rate, and breathing will be monitored before, during, and after the PET scan. A second catheter will be inserted in the artery of the wrist so blood can be drawn during the scan. Some participants may return for a second PET scan; have a lung scan or receive apremilast. https://nimhcontent.nimh.nih.gov/start/surveys/?s=KE88DXXPLDFHHTF8 Type: Interventional Start Date: Jun 2023 |
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Anxiety Sensitivity Treatment to Reduce Anxiety in Alzheimer's
Florida State University
Anxiety
Mild Cognitive Impairment
Alzheimer Disease
Dementia
The goal of this clinical trial is to test the effectiveness of a computerized anxiety
sensitivity treatment (CAST) compared to a health education control (HEC) in older adults
with mild cognitive impairment (MCI) or mild Alzheimer's Disease and related dementias
(ADRD) and their care partners. The1 expand
The goal of this clinical trial is to test the effectiveness of a computerized anxiety sensitivity treatment (CAST) compared to a health education control (HEC) in older adults with mild cognitive impairment (MCI) or mild Alzheimer's Disease and related dementias (ADRD) and their care partners. The main questions it aims to answer are: 1. Efficacy of CAST in reducing anxiety and related symptoms among those with MCI/mild ADRD 2. Efficacy of CAST in reducing care partner burden among care partners of people living with MCI/mild ADRD 3. Explore treatment mechanisms using a multi-modal assessment battery of anxiety sensitivity and anxiety Participants will complete six in-person visits including a baseline assessment, two intervention sessions, and three follow-up assessments at 1, 3, and 6-months posttreatment. Participants will also complete three weeks of ecological momentary assessments (EMAs) for one week prior to intervention, one week between intervention sessions, and one week after intervention. If there is a comparison group: Researchers will compare CAST to HEC to see if CAST reduces anxiety and related symptoms in older adults with MCI/mild ADRD and care partner burden to a greater degree than HEC. Type: Interventional Start Date: Nov 2023 |
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Wellness App for Sleep Disturbance in Hematological Cancer Patients
The University of Texas Health Science Center at San Antonio
Cancer
Sleep Disturbance
Anxiety
Depression
Inflammation
In a randomized controlled trial (RCT), the investigators will recruit participants to an
8-week "app-based wellness" intervention, followed by a 12-week follow-up period. The
investigators will recruit a total of 276 self-declared Chronic Hematological Cancer
(CHC) patients who (representative of1 expand
In a randomized controlled trial (RCT), the investigators will recruit participants to an 8-week "app-based wellness" intervention, followed by a 12-week follow-up period. The investigators will recruit a total of 276 self-declared Chronic Hematological Cancer (CHC) patients who (representative of age, race/ethnicity, and gender) will be on stable CHC pharmacologic therapy (if any), self-identify as sleep disturbed (>5 on Pittsburgh Sleep Quality Index), do not have a sleep disorder diagnosis, do not take sleep medication/supplements >3 times per week, and are not currently practicing regular meditation. Aim 1: Test the efficacy of two app-based wellness programs (10 minutes per day) on the primary outcome of self reported sleep disturbance (Insomnia Severity Index (primary) and PROMIS Sleep Disturbance (secondary)) and secondary sleep outcomes including sleep impairment (PROMIS Sleep Impairment Scale) and sleep efficiency measured via sleep diaries and actigraphy. Aim 2: Test the efficacy of two app-based wellness programs (10 minutes per day) on inflammatory markers (i.e., TNF-a, IL-6, IL-8, CRP), fatigue, and emotional distress (i.e., anxiety, depressive symptoms measured with PROMIS®). Aim 3: Explore the sustained effects (i.e., 20 weeks from baseline) of two app-based wellness programs (10 minutes per day) in CHC patients. Type: Interventional Start Date: Feb 2023 |
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Exercise for Anxiety
NYU Langone Health
Anxiety
90 sedentary adults with a primary anxiety disorder and high anxiety sensitivity will be
randomized to either 8 weeks of 1) low intensity exercise, or 2) flexible titration to
high intensity exercise (HIE). Blinded, validated clinician-rated and patient-rated
outcomes will be assessed over treatmen1 expand
90 sedentary adults with a primary anxiety disorder and high anxiety sensitivity will be randomized to either 8 weeks of 1) low intensity exercise, or 2) flexible titration to high intensity exercise (HIE). Blinded, validated clinician-rated and patient-rated outcomes will be assessed over treatment and at 1- and 3-month follow-up. To better understand what mechanisms influence decisions to exercise in the real-world, we will use of heart rate (HR) as an objective mechanistic target for exercise intensity, examine changes in valuation of exercise through a neuroeconomics task, examine changes in interoceptive sensitivity with a heartbeat detection task, and integrate of ecological momentary assessment (EMA) to measure effects of immediate changes in mood with exercise on anxiety outcomes and adherence. Type: Interventional Start Date: Jun 2021 |
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Psilocybin Therapy for Depression in Parkinson's Disease
Joshua Woolley, MD, PhD
Parkinson Disease
Depression
The purpose of this study is to understand whether people with Parkinson's Disease and
depression have improvement in their symptoms after psilocybin therapy. expand
The purpose of this study is to understand whether people with Parkinson's Disease and depression have improvement in their symptoms after psilocybin therapy. Type: Interventional Start Date: Aug 2024 |
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Pharmacogenetically-guided Escitalopram Treatment for Pediatric Anxiety: Aiming to Improve Safety a1
University of Cincinnati
Anxiety
This double-blind, 12-week study will consist include132 anxious youth who are randomized
(1:1) to standard or pharmacogenetically-guided escitalopram dosing. Block randomization
(1:1) will be stratified by sex and metabolizer status. expand
This double-blind, 12-week study will consist include132 anxious youth who are randomized (1:1) to standard or pharmacogenetically-guided escitalopram dosing. Block randomization (1:1) will be stratified by sex and metabolizer status. Type: Interventional Start Date: Mar 2021 |
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Cognitive Enhancement in Depression (The COG-D Study)
Vanderbilt University Medical Center
Aging
Depression
Cognitive Symptom
This study will investigate whether transcranial direct current stimulation (tDCS)
enhances the effects of computerized cognitive training in older adults with recurrent
depression (2 or more lifetime episodes; either current or within past 3 years). expand
This study will investigate whether transcranial direct current stimulation (tDCS) enhances the effects of computerized cognitive training in older adults with recurrent depression (2 or more lifetime episodes; either current or within past 3 years). Type: Interventional Start Date: Feb 2023 |
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Mobile App for Latinx Hazardous Drinkers With Clinical Anxiety
Michael J. Zvolensky, Ph.D.
Alcohol Abuse
Anxiety
The purpose of this study is to develop and examine a culturally adapted, brief,
integrated, Spanish language mobile health application for the Android platform,
optimized to deliver a personalized feedback intervention (PFI) designed to enhance
knowledge regarding adverse anxiety-alcohol interrela1 expand
The purpose of this study is to develop and examine a culturally adapted, brief, integrated, Spanish language mobile health application for the Android platform, optimized to deliver a personalized feedback intervention (PFI) designed to enhance knowledge regarding adverse anxiety-alcohol interrelations, increase motivation and intention to reduce hazardous drinking, and reduce positive attitudes and intention regarding anxiety-related alcohol use among Latinx hazardous drinkers with clinical anxiety. Type: Interventional Start Date: Nov 2022 |
