Search Clinical Trials
Before medications are approved by the U.S. Food and Drug Administration (FDA) or before certain therapy methods are widely accepted as effective, they are tested on people who volunteer to participate in a clinical trial.
Organizations across the country are looking for people like you to take part in their research studies. The list of studies below have been selected from ClinicalTrials.gov based on their inclusion of one or more of the following terms: anxiety disorders, depression, OCD, PTSD, and bipolar disorder.
The Anxiety and Depression Association of America (ADAA) is supportive of research that is conducted through clinical trials. Participating in research can potentially help change the mental health outcomes for you and others who suffer anxiety, depression, and related disorders. You may learn about new interventions/treatments that are being considered.
Read this ADAA blog about things to know and questions to ask before committing to a clinical trial.
This website page is brought to you in partnership with ResearchMatch.
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Determining Optimal Treatment Sequences in Anxious Depression (DOTS-AD)
University of Cincinnati
Anxious Depression
Depression
Acute, double-blind, adaptively randomized treatment with duloxetine or escitalopram,
followed by double-blind, randomized adjunctive treatment with clonazepam or pregabalin
for persistent symptoms. expand
Acute, double-blind, adaptively randomized treatment with duloxetine or escitalopram, followed by double-blind, randomized adjunctive treatment with clonazepam or pregabalin for persistent symptoms. Type: Interventional Start Date: Mar 2020 |
Cannabidiol Solution for the Treatment of Behavioral Symptoms in Older Adults With Mild Cognitive Impairment...
Mclean Hospital
Alzheimer Disease
Anxiety
Agitation,Psychomotor
This is an open label, eight week, clinical trial of a proprietary high CBD/low THC
sublingual solution for the treatment of clinically significant anxiety and agitation in
individuals with mild cognitive impairment (MCI) or mild to moderate Alzheimer's Disease
(AD). expand
This is an open label, eight week, clinical trial of a proprietary high CBD/low THC sublingual solution for the treatment of clinically significant anxiety and agitation in individuals with mild cognitive impairment (MCI) or mild to moderate Alzheimer's Disease (AD). Type: Interventional Start Date: Jan 2021 |
Accelerated iTBS for Post Partum Depression
Medical University of South Carolina
Post Partum Depression
Study 1: The investigators are studying the feasibility and tolerability of 10x/day
intermittent theta burst (excitatory) transcranial magnetic stimulation to the left
dorsolateral prefrontal cortex over the course of 6 days for women with post-partum
depression. The investigators further aim to characterize... expand
Study 1: The investigators are studying the feasibility and tolerability of 10x/day intermittent theta burst (excitatory) transcranial magnetic stimulation to the left dorsolateral prefrontal cortex over the course of 6 days for women with post-partum depression. The investigators further aim to characterize the anticipated anti-depressant effect of this treatment paradigm. Study 2: The investigators are studying the feasibility and tolerability of 12 sessions/day of intermittent theta burse (excitatory) transcranial magnetic stimulation to the left dorsolateral prefrontal cortex over 5 days for women with post-partum depression. The investigators aim to compare the two different treatment schedules. Type: Interventional Start Date: Jan 2018 |
rTMS to Target Neural Connectivity and Rumination in Treatment-Resistant Depression
Indiana University
Depression, Treatment Resistant
The goal of this clinical trial is to learn if Transcranial Magnetic Stimulation (TMS) to
part of the brain called the ventromedial prefrontal cortex (VMPFC) can treat a symptom
called rumination in adults with major depression that has not responded to at least one
medication trial. The main question... expand
The goal of this clinical trial is to learn if Transcranial Magnetic Stimulation (TMS) to part of the brain called the ventromedial prefrontal cortex (VMPFC) can treat a symptom called rumination in adults with major depression that has not responded to at least one medication trial. The main question it aims to answer are: Does TMS to the VMPFC change brain activity on functional magnetic resonance imaging (fMRI) during a negative self-referential processing task in adults with depression? Does TMS to the VMPFC affect rumination in adults with depression? Researchers will compare brain scans and rumination scores before, during, and immediately after TMS. Participants will: Undergo three functional MRI scans Undergo a course of 20 TMS treatments Respond to clinical questionnaires and complete a computer behavioral task Type: Interventional Start Date: Jan 2024 |
Accelerated rTMS for Substance Use Disorder and Depression
University of Texas Southwestern Medical Center
Stimulant Use
Depression
This study is a small open-label feasibility trial of an accelerated course of repetitive
transcranial magnetic stimulation (rTMS) for individuals with depression and stimulant
use disorder [including methamphetamine or cocaine use disorder (MUD/CUD)]. expand
This study is a small open-label feasibility trial of an accelerated course of repetitive transcranial magnetic stimulation (rTMS) for individuals with depression and stimulant use disorder [including methamphetamine or cocaine use disorder (MUD/CUD)]. Type: Interventional Start Date: Jun 2024 |
A Study of CLE-100 (Oral Esketamine) as an Adjunctive Treatment to Standard Antidepressants for Major...
Clexio Biosciences Ltd.
Adjunctive Treatment of Major Depressive Disorder (MDD)
The study is a Phase 2, double-blind, randomized, placebo-controlled study in Major
Depressive Disorder (MDD) participants with an inadequate response to standard
antidepressants The objective of the study is to assess CLE-100 (oral esketamine) for the
treatment of MDD in participants currently treated... expand
The study is a Phase 2, double-blind, randomized, placebo-controlled study in Major Depressive Disorder (MDD) participants with an inadequate response to standard antidepressants The objective of the study is to assess CLE-100 (oral esketamine) for the treatment of MDD in participants currently treated with an oral antidepressant medication and who have an inadequate response to at least 2 antidepressants. Type: Interventional Start Date: Mar 2024 |
Reducing Mental Health Disparities Among Latinxs With a Telenovela Intervention
University of Nevada, Reno
Anxiety Disorders
The primary aim of our study is to determine the effectiveness of an transdiagnostic
telenovela video intervention in reducing anxiety and depressive symptoms using a
pre/post-test design with Spanish-speaking Latinxs. expand
The primary aim of our study is to determine the effectiveness of an transdiagnostic telenovela video intervention in reducing anxiety and depressive symptoms using a pre/post-test design with Spanish-speaking Latinxs. Type: Interventional Start Date: Jul 2024 |
Music-Based Interventions, Aging, Alzheimer's Disease
University of Southern California
Speech Perception
Anxiety
Social Behavior
Using a randomized controlled trial design, the investigators will examine the effects of
music engagement through choir training on the hearing, communication, and psychosocial
well-being of older adults, particularly those at heightened risk of developing dementia. expand
Using a randomized controlled trial design, the investigators will examine the effects of music engagement through choir training on the hearing, communication, and psychosocial well-being of older adults, particularly those at heightened risk of developing dementia. Type: Interventional Start Date: Oct 2024 |
Psychotherapy Effects on Reward Processing in PTSD
University of Texas at Austin
Post Traumatic Stress Disorder
Diminished Pleasure
Anhedonia
PTSD
Chronic PTSD
The purpose of this study is to identify how trauma-focused psychotherapy changes the
function of brain circuitry in posttraumatic stress disorder (PTSD) and how this mediates
improvements in the diminished ability to experience positive emotions following a
traumatic or extremely stressful life event.... expand
The purpose of this study is to identify how trauma-focused psychotherapy changes the function of brain circuitry in posttraumatic stress disorder (PTSD) and how this mediates improvements in the diminished ability to experience positive emotions following a traumatic or extremely stressful life event. In this instance, the investigators will be using cognitive processing therapy (CPT), a widely-utilized and evidence-based treatment for PTSD. Type: Interventional Start Date: Jun 2024 |
Cancer Pain Management Using a Web-based Intervention
University of Texas at Austin
Cancer of Breast
Depressive Symptoms
Cancer Pain
This study is funded by the HEAL Initiative (https://heal.nih.gov/). Based on Preliminary
Studies (PSs), the research team developed and pilot-tested an evidence-based Web
App-based information and coaching/support program for cancer pain management (CAPA) that
was culturally tailored to Asian American... expand
This study is funded by the HEAL Initiative (https://heal.nih.gov/). Based on Preliminary Studies (PSs), the research team developed and pilot-tested an evidence-based Web App-based information and coaching/support program for cancer pain management (CAPA) that was culturally tailored to Asian American breast cancer survivors using multiple unique features. However, CAPA rarely considered depressive symptoms accompanying pain in its design or components, and PSs indicated the necessity of further individualization of the intervention components of CAPA due to diversities in the needs of ABD. The purpose of the proposed 2-phase study is to further develop CAPA with additional components for ABD and the individual optimization functionality (CAI) and to test the efficacy of CAI in improving cancer pain experience of ABD. The specific aims are to: a) develop and evaluate CAI through an expert review and a usability test (R61 phase); b) determine whether the intervention group (that uses CAI and usual care) will show significantly greater improvements than the active control group (that uses CAPA and usual care) in primary outcomes (cancer pain management and cancer pain experience including depressive symptoms) from baseline to post 1-month and post 3-months; c) identify theory-based variables (attitudes, self-efficacy, perceived barriers, and social influences) that mediate the intervention effects of CAI on the primary outcomes; and d) determine whether the effects of CAI on the primary outcomes are moderated by selected background, disease, genetic, and situational factors. This study is guided by the Bandura's Theory and the stress and coping framework by Lazarus and Folkman. The R61 phase includes: (a) the intervention development process, (b) a usability test among 15 ABD, 15 family members, and 15 community gatekeepers; and (c) an expert review among 10 experts in oncology. The R33 phase adopts a randomized repeated measures control group design among 300 ABD. Long-term goals are: (a) to extend and test CAI in various healthcare settings with diverse subgroups of ABD, (b) examine the costeffectiveness, sustainability, and scalability of CAI in the settings, and (c) translate CAI into health care for ABD. Type: Interventional Start Date: Feb 2024 |
Intervention to Reduce Safety Behaviors
VA Office of Research and Development
Social Anxiety
Social anxiety is associated with significant deficits in social and occupational
functioning. The proposed study seeks to evaluate the feasibility of implementing a brief
text-based intervention for decreasing social anxiety related safety behaviors among
Veterans attempting to re-integrate into... expand
Social anxiety is associated with significant deficits in social and occupational functioning. The proposed study seeks to evaluate the feasibility of implementing a brief text-based intervention for decreasing social anxiety related safety behaviors among Veterans attempting to re-integrate into the workforce. Findings from this pilot will support a larger randomized controlled study examining the efficacy of the intervention for improving functional outcomes and quality of life among Veterans. Type: Interventional Start Date: Jul 2024 |
5-HTP and Creatine for Depression R33 Phase
University of Utah
Major Depressive Disorder
This is a three-armed clinical trial examining the effect of 5-hydroxytryptophan and
creatine monohydrate as augmenting agents for the treatment of depression. Subjects will
be randomized between 5-HTP 100mg BID + creatine 5g daily, 5-HTP 200mg BID + creatine 10g
daily, vs double placebo, for 8 weeks.... expand
This is a three-armed clinical trial examining the effect of 5-hydroxytryptophan and creatine monohydrate as augmenting agents for the treatment of depression. Subjects will be randomized between 5-HTP 100mg BID + creatine 5g daily, 5-HTP 200mg BID + creatine 10g daily, vs double placebo, for 8 weeks. The ability of the interventions to affect biomarkers associated with depression will be assessed using brain phosphorus magnetic resonance spectroscopy, functional connectivity imaging, and plasma serotonin levels. Type: Interventional Start Date: Sep 2023 |
Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of Sleep Deprivation
University of Pennsylvania
Major Depressive Disorder
In the treatment of Major Depressive Disorder (MDD), total sleep deprivation can produce
rapid but short-lasting improvements in mood. In order to develop a new generation of
treatments with rapid and sustained efficacy, a better understanding of the mechanism of
action is urgently needed. One candidate... expand
In the treatment of Major Depressive Disorder (MDD), total sleep deprivation can produce rapid but short-lasting improvements in mood. In order to develop a new generation of treatments with rapid and sustained efficacy, a better understanding of the mechanism of action is urgently needed. One candidate mechanism is the modulation of synaptic strength mediated by glutamatergic activity as sleep deprivation has been suggested to increase synaptic strength. Although determining how sleep deprivation impacts the glutamatergic system is essential to isolating its mechanism of action, the invasive nature of most assessment methods has limited our ability to do so in humans. The proposed research aims to determine if changes in glutamatergic activity, reflecting the modulation of synaptic strength, underlie the antidepressant effects of sleep deprivation. In this project, the investigators will utilize a novel measure of glutamate imaging, GluCEST, to assess changes in glutamatergic activity, in addition to using a proxy measure, waking EEG theta activity, to assess synaptic strength following total sleep deprivation. Ten individuals (aged 18-85) with a DSM-V diagnosis of MDD will undergo baseline GluCEST imaging and waking EEG prior to and following approximately 30 hours of total sleep deprivation. Both clinician-administered and subjective mood measures will be collected. It is predicted that sleep deprivation will improve mood and increase glutamatergic activity and synaptic strength. Results from this project have the potential to identify the modifiable mechanisms by which rapid antidepressants work which could ultimately stimulate the development of novel interventions that work through the modulation of glutamatergic activity. Type: Observational Start Date: Jun 2023 |
Storytelling and Mindfulness for Graduate Student Wellbeing
University of Wisconsin, Madison
Depression
Anxiety
Burnout, Student
The purpose of this study is to evaluate an intervention for improving Science,
Technology, Engineering, and Math (STEM) graduate student wellbeing. Participants will be
recruited from the University of Wisconsin-Madison graduate student body. Data will be
collected from participants for up to 2 years,... expand
The purpose of this study is to evaluate an intervention for improving Science, Technology, Engineering, and Math (STEM) graduate student wellbeing. Participants will be recruited from the University of Wisconsin-Madison graduate student body. Data will be collected from participants for up to 2 years, and the investigators anticipate that the study will last for 4 years. Type: Interventional Start Date: Mar 2023 |
Factorial Optimization Trial to Test Effects of Coping Intervention Components
Arizona State University
Anxiety
Depression
Coping Skills
Emotional Problem
This study will identify components for inclusion in a coping intervention package to
reduce mental health problems among children exposed to high interparental conflict after
parental separation/divorce. Reappraisal, distraction, and relaxation coping strategies
are related to fewer mental health... expand
This study will identify components for inclusion in a coping intervention package to reduce mental health problems among children exposed to high interparental conflict after parental separation/divorce. Reappraisal, distraction, and relaxation coping strategies are related to fewer mental health problems among children, making intervention components based on these strategies key candidates for inclusion in an optimized coping intervention. The primary aim is to experimentally assess the main and interactive effects of three digital intervention coping components (reappraisal, distraction, relaxation) on children's coping efficacy, emotional security, and internalizing and externalizing problems. Secondary aims are to assess indirect effects of the intervention components on children's coping efficacy, emotional security, and internalizing and externalizing problems through their cognitive, emotional, and behavioral reactions to post-separation/divorce interparental conflict events. Type: Interventional Start Date: Feb 2023 |
taVNS or TMS or Both for Depression
Medical University of South Carolina
Depression
The purpose of the research is to test out a combined treatment for depression where the
investigators stimulate a nerve in the ear while at the same time stimulate the brain
with magnets. These treatments are called transcutaneous (through the skin) auricular
(ear) vagus nerve stimulation (taVNS)... expand
The purpose of the research is to test out a combined treatment for depression where the investigators stimulate a nerve in the ear while at the same time stimulate the brain with magnets. These treatments are called transcutaneous (through the skin) auricular (ear) vagus nerve stimulation (taVNS) and transcranial (through the skull) magnetic stimulation (TMS). For participants who already have a cervical VNS device, the investigators will not change their treatment and will use this in place of the taVNS. The investigators think this combined method might treat depressive symptoms better than either alone. This study is in person at the Institute of Psychiatry in downtown Charleston on the MUSC campus. First, participants will have a screening session and then will have 6 treatment days total where participants will receive either VNS treatment alone, TMS treatment alone, or both at the same time. The treatment that participants start with will be randomized, and they will have 2 treatment days of each combination. Type: Interventional Start Date: Mar 2023 |
IGC-AD1 Trial on Agitation in Dementia Due to Alzheimer's
IGC Pharma LLC
Alzheimer Disease
Agitation,Psychomotor
Depression
Anxiety
Memory Impairment
The purpose of this study is to assess the efficacy of an oral medication, IGC-AD1 that
is a natural THC-based (Tetrahydrocannabinol) formulation, administered in micro doses,
twice a day, on symptomatological Agitation, in patients with mild to severe dementia
from Alzheimer's. expand
The purpose of this study is to assess the efficacy of an oral medication, IGC-AD1 that is a natural THC-based (Tetrahydrocannabinol) formulation, administered in micro doses, twice a day, on symptomatological Agitation, in patients with mild to severe dementia from Alzheimer's. Type: Interventional Start Date: Oct 2022 |
Decoding and Modulating Affective Brain States
University of Pennsylvania
Rumination
Major Depressive Disorder
Anxiety
Generating personalized brain signatures of negative emotion along with personalized
brain stimulation protocols to disrupt these patterns. We plan to use fMRI and muscle
activity data to determine negative affect maps for each participant. We will then try a
variety of patterned repetitive transcranial... expand
Generating personalized brain signatures of negative emotion along with personalized brain stimulation protocols to disrupt these patterns. We plan to use fMRI and muscle activity data to determine negative affect maps for each participant. We will then try a variety of patterned repetitive transcranial magnetic stimulation sequences while recording fMRI which will be the basis of two sessions of 3-day individualized brain stimulation designed to reduce negative affect. Type: Interventional Start Date: Feb 2023 |
Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment...
University of Alabama at Birmingham
Major Depressive Disorder
Suicidal Ideas
Suicide, Attempted
MDD
Depression
This study is dedicated to help identify biomarkers for depression and suicide. The
purpose of the study is to better understand these links to improve medical and
psychiatric care in the future. This research is also to test the effects of standard
treatment of depression on improvement in depressive... expand
This study is dedicated to help identify biomarkers for depression and suicide. The purpose of the study is to better understand these links to improve medical and psychiatric care in the future. This research is also to test the effects of standard treatment of depression on improvement in depressive and suicidal behavior and on biomarkers (e.g. miRNA) for these disorders. Type: Interventional Start Date: Oct 2022 |
Psilocybin in Co-occuring Major Depressive Disorder and Borderline Personality Disorder
University of Chicago
Borderline Personality Disorder
Major Depressive Disorder
The primary objective of the study is to evaluate the safety and efficacy of psilocybin
in adults with major depressive disorder (MDD) and borderline personality disorder (BPD). expand
The primary objective of the study is to evaluate the safety and efficacy of psilocybin in adults with major depressive disorder (MDD) and borderline personality disorder (BPD). Type: Interventional Start Date: Nov 2023 |
Utility of Brexanolone to Target Stress-induced Alcohol Use Among Men and Women With Posttraumatic Stress...
Yale University
PTSD
Alcohol Use Disorder
For this protocol, the investigators plan to collect pilot data to: 1. establish the
feasibility and safety of administering brexanolone to individuals with concurrent
Posttraumatic Stress Disorder (PTSD) and Alcohol Use Disorder (AUD). expand
For this protocol, the investigators plan to collect pilot data to: 1. establish the feasibility and safety of administering brexanolone to individuals with concurrent Posttraumatic Stress Disorder (PTSD) and Alcohol Use Disorder (AUD). Type: Interventional Start Date: Aug 2023 |
Treatments for Insomnia in Veterans With PTSD
VA Office of Research and Development
Insomnia
PTSD
This randomized trial will compare a novel treatment, Acceptance of the Behavioral
Changes to Treat Insomnia (ABC-I) to Cognitive Behavioral Therapy for Insomnia (CBT-I)
among Veterans with comorbid Post-Traumatic Stress Disorder (PTSD) and insomnia disorder.
ABC-I combines the behavioral components... expand
This randomized trial will compare a novel treatment, Acceptance of the Behavioral Changes to Treat Insomnia (ABC-I) to Cognitive Behavioral Therapy for Insomnia (CBT-I) among Veterans with comorbid Post-Traumatic Stress Disorder (PTSD) and insomnia disorder. ABC-I combines the behavioral components of CBT-I with components of another behavioral therapy (Acceptance and Commitment Therapy) and has been shown to improve treatment adherence. The study objectives are: 1) to evaluate the benefits of ABC-I in reducing post-traumatic stress disorder (PTSD) symptoms among Veterans with comorbid PTSD and insomnia disorder compared to CBT-I, and 2) to evaluate the effectiveness of ABC-I in improving insomnia symptoms and sleep quality among Veterans with comorbid PTSD and insomnia disorder as compared to CBT-I. Veterans with insomnia and comorbid PTSD who receive care at Sepulveda and West Los Angeles facilities will be recruited for the study. Those who pass an initial eligibility screen will be enrolled and written informed consent will be obtained. A baseline assessment will be completed that includes measures of sleep, PTSD, and quality of life. Veterans who meet all eligibility criteria will be randomly assigned to the ABC-I (n=100) or CBT-I (n=100) treatment. Both treatments will be provided in 5 one-on-one sessions by a trained instructor who is supervised by a behavioral sleep medicine specialist. All randomized participants (n=200) will have 3 follow-up assessments (post-treatment, 3-months, and 6-months after randomization). The follow-up assessments will collect information on PTSD symptoms, insomnia symptoms and sleep quality. Type: Interventional Start Date: Sep 2022 |
Cognitive Behavioral Therapy Following Esketamine for Major Depression and Suicidal Ideation for Relapse...
Yale University
Depression and Suicide
This is a rater-blinded, randomized controlled trial. All patients will receive
esketamine for treatment of Major Depression with Suicidal Ideation (MDSI). Subjects will
be randomized (1:1) to receive CBT (computer-assisted) or TAU alone following esketamine. expand
This is a rater-blinded, randomized controlled trial. All patients will receive esketamine for treatment of Major Depression with Suicidal Ideation (MDSI). Subjects will be randomized (1:1) to receive CBT (computer-assisted) or TAU alone following esketamine. Type: Interventional Start Date: Mar 2021 |
Rapid Antidepressant Improvement Secondary to Excitatory Brain Responses
Marta Peciña, MD PhD
Major Depressive Disorder
Depression
The central goal of this application is to demonstrate the causal contribution of reward
learning signals (expected values and reward prediction errors [RPE]) to antidepressant
responses (Aim1) by experimentally manipulating expected values using transcranial
magnetic stimulation (TMS) targeting the... expand
The central goal of this application is to demonstrate the causal contribution of reward learning signals (expected values and reward prediction errors [RPE]) to antidepressant responses (Aim1) by experimentally manipulating expected values using transcranial magnetic stimulation (TMS) targeting the vmPFC (Aim 2) and μ-opioid striatal RPE signal using pharmacological approaches (Aim 3). Type: Interventional Start Date: Oct 2020 |
Patient Outcome Reporting for Timely Assessments of Life With Post-Traumatic Stress Disorder
University of Chicago
PTSD
This study aims to implement and evaluate a more timely approach to post-traumatic stress
disorder (PTSD) diagnosis and management, entitled Patient Outcome Reporting for Timely
Assessments of Life with Post-Traumatic Stress Disorder (PORTAL-PTSD) in a primary care
setting with a high prevalence of... expand
This study aims to implement and evaluate a more timely approach to post-traumatic stress disorder (PTSD) diagnosis and management, entitled Patient Outcome Reporting for Timely Assessments of Life with Post-Traumatic Stress Disorder (PORTAL-PTSD) in a primary care setting with a high prevalence of trauma, specifically the South Side of Chicago, in partnership with Chicago Family Health Center (CFHC). Type: Interventional Start Date: Jul 2024 |
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