Search Clinical Trials
Before medications are approved by the U.S. Food and Drug Administration (FDA) or before certain therapy methods are widely accepted as effective, they are tested on people who volunteer to participate in a clinical trial.
Organizations across the country are looking for people like you to take part in their research studies. The list of studies below have been selected from ClinicalTrials.gov based on their inclusion of one or more of the following terms: anxiety disorders, depression, OCD, PTSD, and bipolar disorder.
The Anxiety and Depression Association of America (ADAA) is supportive of research that is conducted through clinical trials. Participating in research can potentially help change the mental health outcomes for you and others who suffer anxiety, depression, and related disorders. You may learn about new interventions/treatments that are being considered.
Read this ADAA blog about things to know and questions to ask before committing to a clinical trial.
This website page is brought to you in partnership with ResearchMatch.
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Exploratory Study for Toivoa-001 on Human Factors
Toivoa Inc
Anxiety Depression
Disability Physical
The Study will evaluate Rauha as an experimental digital therapeutic for persons with
Disabilities suffering from anxiety and/or depression. The study will evaluate completion
rates of the program and survey the user's experience upon completion. Changes in anxiety
and depression scores will be monitored... expand
The Study will evaluate Rauha as an experimental digital therapeutic for persons with Disabilities suffering from anxiety and/or depression. The study will evaluate completion rates of the program and survey the user's experience upon completion. Changes in anxiety and depression scores will be monitored during the study. Type: Interventional Start Date: Jun 2024 |
Weighted Blanket to Treat Anxiety Related to Trying New Foods the Pediatric Population
The University of Texas Medical Branch, Galveston
Food Neophobia
Picky Eating
Avoidant Restrictive Food Intake Disorder
Anxiety State
This small experimental pilot study addresses the knowledge gap related to the use of
weighted blankets for children with anxiety related to food and eating. expand
This small experimental pilot study addresses the knowledge gap related to the use of weighted blankets for children with anxiety related to food and eating. Type: Interventional Start Date: Jun 2024 |
PD, PK, and Safety of ALTO-203 in Patients With MDD
Alto Neuroscience
Major Depressive Disorder
Anhedonia
The goal of this clinical trial is to determine the pharmacodynamic effects of ALTO-203
in patients with MDD in a randomized, placebo-controlled, single-dose crossover treatment
period. Additionally, safety, tolerability, and PK will be assessed in a subsequent
randomized placebo-controlled multi-dose... expand
The goal of this clinical trial is to determine the pharmacodynamic effects of ALTO-203 in patients with MDD in a randomized, placebo-controlled, single-dose crossover treatment period. Additionally, safety, tolerability, and PK will be assessed in a subsequent randomized placebo-controlled multi-dose parallel-group treatment period of 28 days. Participants will complete subjective response questionnaires and perform cognitive tasks during the single-dose period, in which participants will receive ALTO-203 25 μg and 75 μg, as well as placebo. During the multiple-dose period, participants will receive either ALTO-203 25 μg, 75 μg , or placebo. Safety will be assessed over the single dose and 28-day multiple dose periods. Type: Interventional Start Date: Mar 2024 |
Feasibility & Acceptability of App-based Cognitive Behavioral Therapy for Postpartum Depression Prevention
Women and Infants Hospital of Rhode Island
Postpartum Depression
Postpartum Anxiety
Stress
Postpartum depression (PPD) affects up 10-15% of mothers overall, but the rate of PPD can
be as high as 25% among mothers with personal or obstetric risk factors. The Mothers &
Babies Program (MB) is a cognitive behavioral therapy (CBT)-based program that has been
shown to prevent PPD among high-risk... expand
Postpartum depression (PPD) affects up 10-15% of mothers overall, but the rate of PPD can be as high as 25% among mothers with personal or obstetric risk factors. The Mothers & Babies Program (MB) is a cognitive behavioral therapy (CBT)-based program that has been shown to prevent PPD among high-risk mothers without a prior history of depression. MB has been so consistently effective that the United States Preventive Services Task Force recommends this program be given to high-risk pregnant patients. Originally designed to be given in-person and via groups, MB has been adapted to be given in person one-on-one in clinic or at home and via text message. However, MB has yet to be adapted to a smartphone application (app). Via evidence-based qualitative research and end-user centered design, MB has been adapted to a novel app, M.Bapp. This study aims to examine the feasibility and acceptability of M.Bapp as a study intervention for perinatal patients as well as provide preliminary estimates of effect for the intervention. Type: Interventional Start Date: Jun 2024 |
A Study to Evaluate the Efficacy and Safety of NBI-1070770 in Adults With Major Depressive Disorder
Neurocrine Biosciences
Major Depressive Disorder
To evaluate the efficacy, safety, and tolerability of NBI-1070770 compared to placebo on
improving symptoms of depression in participants with major depressive disorder (MDD). expand
To evaluate the efficacy, safety, and tolerability of NBI-1070770 compared to placebo on improving symptoms of depression in participants with major depressive disorder (MDD). Type: Interventional Start Date: Mar 2024 |
IN Midazolam vs IN Dexmedetomidine vs IN Ketamine During Minimal Procedures in Pediatric ED
University of Oklahoma
Laceration of Skin
Anxiety
Discharge Time
Pain in young children has been universally under-recognized due to their inability to
describe or localize pain. Improvements in pharmacological interventions are necessary to
optimize patient and family experience and allow for successful and efficient procedure
completion. This is the first study... expand
Pain in young children has been universally under-recognized due to their inability to describe or localize pain. Improvements in pharmacological interventions are necessary to optimize patient and family experience and allow for successful and efficient procedure completion. This is the first study that will compare three intranasal medications (Intranasal Midazolam, Dexmedetomidine, and Ketamine) to evaluate the length of stay after medication administration along with patient and provider satisfaction. The objective of this study is to demonstrate superior intranasal anxiolysis for pediatric laceration repairs with the shortest emergency department stay and highest patient and provider satisfaction. Based on previous studies and medication pharmacokinetics, we hypothesize that Intranasal Ketamine will have the shortest Emergency Department (ED) stay followed by Midazolam and then Dexmedetomidine with the longest stay; however, Dexmedetomidine will have the highest patient and provider satisfaction followed by Ketamine and then Midazolam. Type: Interventional Start Date: Nov 2023 |
Network Neurofeedback Using 7-Tesla MRI to Reduce Rumination Levels in Depression
Icahn School of Medicine at Mount Sinai
Major Depressive Disorder
Patients with major depressive disorder (MDD) exhibit increased levels of rumination
(i.e. repetitive thinking and focus on negative mood states) which have been found to
increase the risk of depressive relapse. The ability to reduce rumination levels among
these patients is greatly needed. Rumination... expand
Patients with major depressive disorder (MDD) exhibit increased levels of rumination (i.e. repetitive thinking and focus on negative mood states) which have been found to increase the risk of depressive relapse. The ability to reduce rumination levels among these patients is greatly needed. Rumination is known to be associated with the default mode network (DMN) region activity. Implementing the Dependency Network Analysis (DEPNA), a recently developed method by the research team to quantify the connectivity influence of network nodes, found that rumination was significantly associated with lower connectivity influence of the left medial orbitofrontal cortex (MOFC) on the right precuneus, both key regions within the DMN. This study implements the first real-time fMRI neurofeedback (Rt-fMRI-NF) network-based protocol for up-regulation of the MOFC influence on the precuneus in patients with MDD to reduce rumination levels. This will allow for more accurate explicit brain connections modulation than the standard single brain region activity; creating a larger opportunity for target clinical neuromodulation treatment in individuals with MDD. Type: Interventional Start Date: Jul 2023 |
Nurse Family Partnership for Women With Previous Live Births
University of Colorado, Denver
Pregnancy, High Risk
Child Development
Post Partum Depression
The goal of this clinical trial is to test the Nurse Family Partnership (NFP) in mothers
with previous live births (multiparous or multip individuals). The main aims are:
Specific Aim 1-Determine the effectiveness of NFP among multiparous women for reducing
maternal morbidity and improving pregnancy... expand
The goal of this clinical trial is to test the Nurse Family Partnership (NFP) in mothers with previous live births (multiparous or multip individuals). The main aims are: Specific Aim 1-Determine the effectiveness of NFP among multiparous women for reducing maternal morbidity and improving pregnancy outcomes. Specific Aim 2-Determine the effectiveness of NFP among index children (child from pregnancy when mother was enrolled) of multiparous women for improving child outcomes. Specific Aim 3 (Exploratory)-In preparation for a future study of the effects of preventive home-visiting programs on mother-index child-sibling triads, describe siblings (characteristics, role, influence) in the context of nurse home-visiting and evaluate the effectiveness of NFP on outcomes for prior-born siblings younger than 6 years old living in the home, including cognitive development, socioemotional development, and identification and referral to needed services. A supplemental study to this study, led by investigators at Yale and Columbia, includes the following Aims: Aim 1: Test whether the NFP causes variation in DNAm at Glucocorticoid-sensitive sites in infants over the first year of life. Aim 2: Determine whether NFP causes differences in epigenetic age in infants over the first year of life. Aim 3: Evaluate DNAm signatures as predictors of infant development at 12 months of age. Type: Interventional Start Date: Mar 2023 |
Inhibitory Mechanisms of Negative Urgency in Adolescent Suicidal Behavior
University of Minnesota
Suicidal Behavior
Suicidal Ideation
Negative Urgency
Cortical Inhibition
Depression
The goal of this study is to understand why some people act more impulsively when feeling
negative emotions, which is called negative urgency. The researchers hope to understand
how negative urgency relates to the way networks of brain cells communicate with one
another. The researchers will measure... expand
The goal of this study is to understand why some people act more impulsively when feeling negative emotions, which is called negative urgency. The researchers hope to understand how negative urgency relates to the way networks of brain cells communicate with one another. The researchers will measure negative urgency and brain signals in adolescents aged 13-21 years with depression and suicidal thoughts and behaviors. The main questions it aims to answer are: - Whether a type of brain signaling called cortical inhibition is related to negative urgency - Whether depressed adolescents with suicidal behavior have more problems with cortical inhibition than depressed adolescents with suicidal thoughts only - Whether the relationship between negative urgency and cortical inhibition changes over time Adolescents who participate in the study will complete the following activities at the time they join the study, as well as 6 months and 12 months later: - Interviews with researchers and questionnaires to learn about their thoughts, emotions, and symptoms - A questionnaire about impulsive behaviors and negative urgency - Computerized games that measure brain functions - An MRI scan of the brain - Transcranial magnetic stimulation with electroencephalography (TMS-EEG), a way to measure how brain cells communicate (cortical inhibition) using a magnet placed outside of the head and recording brain signals Type: Interventional Start Date: May 2024 |
Toward Understanding Drivers of Patient Engagement With Digital Mental Health Interventions - Part II
Brigham and Women's Hospital
Depression
Anxiety Disorders
This study is a clinical trial that evaluates what drives patient engagement and tests
the impact of two strategies-automated motivational push messaging and coach support-to
improve engagement with an evidence-based mobile app intervention for depression and/or
anxiety. expand
This study is a clinical trial that evaluates what drives patient engagement and tests the impact of two strategies-automated motivational push messaging and coach support-to improve engagement with an evidence-based mobile app intervention for depression and/or anxiety. Type: Interventional Start Date: Jun 2023 |
Treatment for Antepartum Posttraumatic Stress Disorder/PTSD Study
Boston University
PTSD
The majority of women with perinatal posttraumatic stress disorder (PTSD) do not receive
mental health treatment despite the documented associations between PTSD and adverse
pregnancy outcomes; this is likely due to workforce shortages, lack of data on the
effectiveness of existing evidence-based... expand
The majority of women with perinatal posttraumatic stress disorder (PTSD) do not receive mental health treatment despite the documented associations between PTSD and adverse pregnancy outcomes; this is likely due to workforce shortages, lack of data on the effectiveness of existing evidence-based treatment for PTSD in usual care obstetrics settings, and patient-level barriers to engagement such as stigma. The proposed study is a randomized controlled trial, which will examine the effectiveness of a brief evidence-based treatment for PTSD (i.e., Written Exposure Therapy) during pregnancy and the non-inferiority of delivery of this treatment by community health workers vs. delivery by mental health clinicians. Type: Interventional Start Date: Mar 2023 |
Repetitive Transcranial Magnetic Stimulation and Acceptance and Commitment Therapy
VA Office of Research and Development
Chronic Pain
Depression
Veterans with comorbid chronic pain and depression are highly prevalent, have poor
functional status and low quality of life, are at increased risk of suicide and lack
access to effective treatments. To address this problem, the proposed research will
examine the feasibility of a novel approach that... expand
Veterans with comorbid chronic pain and depression are highly prevalent, have poor functional status and low quality of life, are at increased risk of suicide and lack access to effective treatments. To address this problem, the proposed research will examine the feasibility of a novel approach that integrates repetitive Transcranial Magnetic Stimulation and Acceptance and Commitment Therapy with the overall goal of maximizing functional improvement in Veterans with chronic pain and depression. This is an important first-step in preparation for a future randomized efficacy trial. The investigators will also include two cognitive control tasks with concurrent electroencephalography to explore as a potential objective indicator of treatment response. This application addresses a critical need within the Veterans Health Administration and is closely aligned with the focus area of developing suicide prevention treatments that influence participation in life roles. Type: Interventional Start Date: May 2023 |
Neural Mechanisms of Meditation Training in Healthy and Depressed Adolescents: An MRI Connectome Study...
University of California, San Francisco
Depression Mild
Depression Moderate
Depression, Teen
The primary objective will be to study changes in putamen connectivity and depression
severity in depressed teens with meditation training. H1: Putamen node strength will
increase in the training group compared to the active controls. H2: This increase in node
strength will correlate with practice... expand
The primary objective will be to study changes in putamen connectivity and depression severity in depressed teens with meditation training. H1: Putamen node strength will increase in the training group compared to the active controls. H2: This increase in node strength will correlate with practice amount recorded by participants. H3: There will be a significant reduction in self-rated depression symptoms following the training as measured by the Reynolds Adolescent Depression Scale (RADS-2), compared to controls. H4: This reduction will correlate with the increase in putamen node strength. Design and Outcomes: The current research study design will utilize an individually randomized group treatment, open-label, active-controlled clinical trial to test the efficacy and safety of the investigator's innovative mindfulness meditation intervention (Training for Awareness Resilience and Action [TARA]) on the primary outcome (Putamen structural node strength) and secondary outcome (depression symptoms measured using Reynolds Adolescent Depression Scale [RADS-2]) in depressed adolescents between the ages of 14 to 18 years old. Type: Interventional Start Date: Feb 2023 |
Engaging Mothers & Babies; Reimagining Antenatal Care for Everyone (EMBRACE) Study
University of California, San Francisco
Premature Birth
Pregnancy Preterm
Prenatal Stress
Depression, Anxiety
Depression, Postpartum
This is a randomized comparative effectiveness study of two forms of enhanced prenatal
care among 657 Medi-Cal eligible pregnant individuals in Fresno, California. The goal is
to see whether group prenatal care with wrap around services versus individual prenatal
care supplemented by services covered... expand
This is a randomized comparative effectiveness study of two forms of enhanced prenatal care among 657 Medi-Cal eligible pregnant individuals in Fresno, California. The goal is to see whether group prenatal care with wrap around services versus individual prenatal care supplemented by services covered by the California Department of Public Health Comprehensive Perinatal Services Program (CPSP) results in less depression and anxiety, and more respectful, more person-centered maternity care and lower rates of preterm birth. Type: Interventional Start Date: Nov 2019 |
Mechanisms of Rumination Change in Adolescent Depression
Ohio State University
Major Depressive Disorder
Mood Disorders
This study will evaluate whether a newer treatment, rumination-focused cognitive
behavioral treatment, which includes mindfulness and can be used to reduce ruminative
habits, change ways in which key brain regions interact with each other (e.g.., often
called connectivity), and whether these changes... expand
This study will evaluate whether a newer treatment, rumination-focused cognitive behavioral treatment, which includes mindfulness and can be used to reduce ruminative habits, change ways in which key brain regions interact with each other (e.g.., often called connectivity), and whether these changes in habits and brain connectivity can reduce the risk for recurrence of depression in the next two years. Type: Interventional Start Date: May 2019 |
Cognitive Behavioral Immersion: A Randomized Control Trial of Peer-Based Coaching in the Metaverse
University of Southern California
Depression, Anxiety
This study will test a new cognitive-behavioral skills training program (CBI) delivered
in the metaverse. Although initial evidence suggested CBI was feasible for individuals
experiencing depression or anxiety, CBI's effectiveness compared to no intervention has
yet to be determined. The intervention... expand
This study will test a new cognitive-behavioral skills training program (CBI) delivered in the metaverse. Although initial evidence suggested CBI was feasible for individuals experiencing depression or anxiety, CBI's effectiveness compared to no intervention has yet to be determined. The intervention may be delivered through virtual reality as well as flat-screen devices, such as a computer, which may also affect CBI's effectiveness. The study will enroll up to 306 participants with depression. One third of the participants will access CBI through virtual reality, one third of the participants will access CBI through a flat-screen device, and one third of the participants will be asked not to attend CBI sessions for the first 8 weeks of participation of the trial. For both CBI conditions, treatment will be provided over 8 weeks, with a 6-month follow-up period. Enrollment will be ongoing and groups will occur simultaneously. Potential participants are asked to complete an initial screening and an intake evaluation to determine eligibility. They will then receive 8-weeks of treatment. Participants will complete brief weekly self-report questionnaires throughout their time in the study. Type: Interventional Start Date: Feb 2024 |
Effect of an Educational Nail Biopsy Video on Pre-operative Anxiety, Health Literacy, and Patient Satisfaction
Weill Medical College of Cornell University
Anxiety
Literacy
Satisfaction, Patient
The investigators are interested in studying the effect of an animated video depicting a
nail biopsy procedure on the anxiety, health literacy, and satisfaction of participants
recommended to undergo a nail biopsy procedure. The investigators hypothesize that the
animated video will reduce preoperative... expand
The investigators are interested in studying the effect of an animated video depicting a nail biopsy procedure on the anxiety, health literacy, and satisfaction of participants recommended to undergo a nail biopsy procedure. The investigators hypothesize that the animated video will reduce preoperative anxiety, increase health literacy, and increase patient satisfaction in relation to nail biopsy procedures. Type: Interventional Start Date: Apr 2024 |
Dose-Response Effect Exercise and Depression
University of Central Florida
Depression
The present study aims to address gaps in the literature by evaluating the objectively
measured dose-response relationship between exercise and depression symptoms; examining
changes in resting (Brain-derived Neurotrophic Factor) BDNF from baseline to week 10 of
an exercise intervention; and assessing... expand
The present study aims to address gaps in the literature by evaluating the objectively measured dose-response relationship between exercise and depression symptoms; examining changes in resting (Brain-derived Neurotrophic Factor) BDNF from baseline to week 10 of an exercise intervention; and assessing varying exercise intensities on enjoyment, affect, and health-related quality of life in sedentary young adult college students. Type: Interventional Start Date: Jul 2023 |
MDMA-assisted Brief Cognitive Behavioral Conjoint Therapy for PTSD
Dr. Leslie Morland
PTSD
Relational Problems
The goal of this pilot trial is to examine the preliminary effectiveness of
MDMA-facilitated bCBCT for improving chronic PTSD and relationship functioning in a
sample of veterans and their intimate partners seeking care within the VA San Diego
Healthcare System. expand
The goal of this pilot trial is to examine the preliminary effectiveness of MDMA-facilitated bCBCT for improving chronic PTSD and relationship functioning in a sample of veterans and their intimate partners seeking care within the VA San Diego Healthcare System. Type: Interventional Start Date: Oct 2023 |
Development of a Transdiagnostic Intervention for Adolescents at Risk for Serious Mental Illness
Massachusetts General Hospital
Anxiety Disorders
Psychotic Disorders
Depressive Disorder
Psychosocial Functioning
This research study aims to develop a brief group-based treatment called Resilience
Training for Teens, then to test how well it protects high school students with mild
symptoms of depression, anxiety, or having unusual feelings from developing mental
illnesses. expand
This research study aims to develop a brief group-based treatment called Resilience Training for Teens, then to test how well it protects high school students with mild symptoms of depression, anxiety, or having unusual feelings from developing mental illnesses. Type: Interventional Start Date: Mar 2024 |
Aromatherapy and Anxiety Study
NYU Langone Health
Anxiety Related to Pain Related to an Intraarticular Injection
Pain Related to an Intraarticular Injection
While intra-articular injections can alleviate pain in orthopedic patients, this can be
an anxiety-provoking experience. Adult patients scheduled to receive an injection at the
study location will be randomly assigned to one of three groups. The control group (C)
will receive the current standard... expand
While intra-articular injections can alleviate pain in orthopedic patients, this can be an anxiety-provoking experience. Adult patients scheduled to receive an injection at the study location will be randomly assigned to one of three groups. The control group (C) will receive the current standard of nursing care. The first experimental group (A) will receive a guided meditation prior to receiving the injection. The second experimental group (B) will receive an Elequil Aromatab and the same guided meditation prior to receiving the injection. Type: Interventional Start Date: Jul 2023 |
Modified Interactive Screening Program Plus MINDBODYSTRONG: A Mental Health Resiliency Intervention for...
Ohio State University
Suicide Threat
Burnout, Professional
Depression
The overall purpose of this study is to evaluate the efficacy of an intervention designed
to prevent nurse suicide. This randomized controlled trial will test the modified
Interactive Screening Program (mISP) alone and the mISP combined with a program called
MINDBODYSTRONG.
The mISP is a method... expand
The overall purpose of this study is to evaluate the efficacy of an intervention designed to prevent nurse suicide. This randomized controlled trial will test the modified Interactive Screening Program (mISP) alone and the mISP combined with a program called MINDBODYSTRONG. The mISP is a method of screening to detect clinicians at moderate to high risk for suicide and referring them for treatment through an encrypted anonymous on-line platform. MINDBODYSTRONG© is an adaptation of a well-tested cognitive-behavioral skills building intervention (also known as COPE in the literature) that provides a cognitive-behavior theory-based approach to decrease depression, anxiety and suicidal ideation and improve healthy lifestyle beliefs and behaviors in at-risk populations. MINDBODYSTRONG© will involve eight self-paced computerized sessions designed specifically for nurses and clinicians. Nurses will be recruited nationally through the professional nursing organizations and health systems. Type: Interventional Start Date: Apr 2023 |
The Neural Underpinnings of Depression and Cannabis Use in Young People Living With HIV
University of Miami
Hiv
Depression
Cannabis Use Disorder
To elucidate mechanisms of substance use disorders (SUD) and comorbid mental illnesses in
people living with HIV (PLWH), the study team seeks to investigate reward and pain
circuitry in cannabis use and depression comorbidity, two highly prevalent conditions in
PLWH. The study team proposes a tightly... expand
To elucidate mechanisms of substance use disorders (SUD) and comorbid mental illnesses in people living with HIV (PLWH), the study team seeks to investigate reward and pain circuitry in cannabis use and depression comorbidity, two highly prevalent conditions in PLWH. The study team proposes a tightly integrative study to test the overall hypothesis that cannabis use and depression in young PLWH have an additive effect, inducing both reward deficits and pain hypersensitivity, and that this pattern will predict worse outcomes at 1 year follow-up. Type: Observational Start Date: Apr 2022 |
Antidepressant Effects of Nitrous Oxide
University of Chicago
Major Depressive Disorder
Treatment Resistant Depression
To evaluate the acute and sustained antidepressant effects of nitrous oxide in people
with major depressive disorder; and further evaluate these effects by identifying the
optimal dose and regimen to guide current practice, and to plan a future large pragmatic
trial. expand
To evaluate the acute and sustained antidepressant effects of nitrous oxide in people with major depressive disorder; and further evaluate these effects by identifying the optimal dose and regimen to guide current practice, and to plan a future large pragmatic trial. Type: Interventional Start Date: Jun 2021 |
Inflammatory and Glutamatergic Mechanisms of Sustained Threat in Adolescents With Depression
University of California, Los Angeles
Depression in Adolescence
Despite the prevalence and significant public health concern over depression among
adolescents, up to 40% of depressed adolescents do not respond to first-line
antidepressants (herein termed treatment non-response, TNR). The goal of this project is
to recruit and assess 160 treatment-seeking depressed... expand
Despite the prevalence and significant public health concern over depression among adolescents, up to 40% of depressed adolescents do not respond to first-line antidepressants (herein termed treatment non-response, TNR). The goal of this project is to recruit and assess 160 treatment-seeking depressed adolescents and test whether acute stress impacts peripheral levels of inflammation and downstream levels of glutamate in corticolimbic regions previously associated with depression, whether these stress-related biomarkers predict TNR to a 12-week trial of either fluoxetine or escitalopram, and whether these stress-related biomarkers predict 18-month clinical course. Type: Observational Start Date: Jul 2023 |
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