Search Clinical Trials
Before medications are approved by the U.S. Food and Drug Administration (FDA) or before certain therapy methods are widely accepted as effective, they are tested on people who volunteer to participate in a clinical trial.
Organizations across the country are looking for people like you to take part in their research studies. The list of studies below have been selected from ClinicalTrials.gov based on their inclusion of one or more of the following terms: anxiety disorders, depression, OCD, PTSD, and bipolar disorder.
The Anxiety and Depression Association of America (ADAA) is supportive of research that is conducted through clinical trials. Participating in research can potentially help change the mental health outcomes for you and others who suffer anxiety, depression, and related disorders. You may learn about new interventions/treatments that are being considered.
Read this ADAA blog about things to know and questions to ask before committing to a clinical trial.
This website page is brought to you in partnership with ResearchMatch.
| Sponsor Condition of Interest |
|---|
|
Gaze-Contingent Music Therapy Augmentation of CBT for Pediatric Anxiety
National Institute of Mental Health (NIMH)
Psychiatric Disorders
Anxiety Disorders
Background:
Anxiety disorders are becoming more common among children and teenagers. Anxiety can lead
to long-term physical and mental problems, such as depression. Treatments for anxiety
disorders include medications as well as cognitive behavioral therapy (CBT); CBT is a
form of talking therapy.1 expand
Background: Anxiety disorders are becoming more common among children and teenagers. Anxiety can lead to long-term physical and mental problems, such as depression. Treatments for anxiety disorders include medications as well as cognitive behavioral therapy (CBT); CBT is a form of talking therapy. Both approaches work in only about 50 percent of cases. A new approach, called gaze-contingent music reward therapy (GCMRT), may help. Objective: To find out whether GCMRT combined with CBT is more effective than CBT alone. Eligibility: Children aged 8 to 17 years with separation anxiety disorder; generalized anxiety disorder; or social anxiety disorder. They must be enrolled in protocol 01-M-0192. Design: Participants will come to the clinic once a week for 4 weeks for CBT. Sometimes the participant will meet with the doctor alone; sometimes their parent may be present. They will do some computer-based tasks: They may be asked to push a button when a target appears; they may look at pictures of faces while the computer tracks their eye movements. Participants will take questionnaires each week. They will answer questions about their anxiety symptoms, feelings, and behavior. For the next 8 weeks, participants will participate in both CBT and 1 of 2 types of GCMRT. GCMRT is a computer-based task. Participants will look at pictures with many faces in them; while they do this, pleasant music will play and stop playing over a 12-minute period. Participants will have a final visit in week 13. They will take questionnaires. They will do final research tasks. Each visit lasts about 2 hours. Type: Interventional Start Date: Dec 2024 |
|
Assessment of Acute Psychomotor Agitation Measures Associated With Schizophrenia and Bipolar Disord1
BioXcel Therapeutics Inc
Bipolar I Disorder
Bipolar II Disorder
Schizophrenia
Schizoaffective Disorder
Schizophreniform Disorders
This open-label study will utilize treatment with BXCL501 in order to assess the
suitability of patient-and lay informant-assessed outcome measures for evaluation of
severity of psychomotor agitation episodes in patients with Bipolar Disorders,
Schizophrenia, Schizoaffective, and Schizophreniform d1 expand
This open-label study will utilize treatment with BXCL501 in order to assess the suitability of patient-and lay informant-assessed outcome measures for evaluation of severity of psychomotor agitation episodes in patients with Bipolar Disorders, Schizophrenia, Schizoaffective, and Schizophreniform disorders and correlate them with clinician-assessed ratings. Type: Interventional Start Date: Jun 2025 |
|
A Behavioral mHealth Intervention for People With HIV With Anxiety and Depression
University of Florida
HIV
Depression
Anxiety
This study will adapt and assess the preliminary effectiveness of a community health
worker-delivered mental health counselling intervention delivered remotely to reduce
anxiety and depression among people with HIV in Florida. expand
This study will adapt and assess the preliminary effectiveness of a community health worker-delivered mental health counselling intervention delivered remotely to reduce anxiety and depression among people with HIV in Florida. Type: Interventional Start Date: Jul 2025 |
|
A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar1
Bristol-Myers Squibb
Bipolar Disorder Type I With Mania or Mania With Mixed Features
This is a Phase 3, randomized, double-blind, placebo-controlled, multicenter, inpatient
study in participants with bipolar disorder experiencing an acute episode of mania or
mania with mixed features.
The primary objective of the study is to evaluate the efficacy of KarXT compared to
placebo in tr1 expand
This is a Phase 3, randomized, double-blind, placebo-controlled, multicenter, inpatient study in participants with bipolar disorder experiencing an acute episode of mania or mania with mixed features. The primary objective of the study is to evaluate the efficacy of KarXT compared to placebo in treating symptoms of mania during a 3-week inpatient period. The duration of the study including screening, the double-blind inpatient treatment period and safety-follow-up is no more than seven weeks. Type: Interventional Start Date: Jun 2025 |
|
Intervention Trial for Healthcare Workers With Anxiety
University of California, Los Angeles
Anxiety
The purpose of the study is to conduct an initial test of the efficacy of Emotional
Resolution (EmRes) therapy to reduce anxiety in healthcare workers. The investigators
hypothesize EmRes will reduce levels of anxiety in participants compared to an active
control group engaged in mindfulness-based1 expand
The purpose of the study is to conduct an initial test of the efficacy of Emotional Resolution (EmRes) therapy to reduce anxiety in healthcare workers. The investigators hypothesize EmRes will reduce levels of anxiety in participants compared to an active control group engaged in mindfulness-based gratitude. Type: Interventional Start Date: Oct 2024 |
|
A Study of the Efficacy and Safety of SP-624 in the Treatment of Adults With Major Depressive Disor1
Sirtsei Pharmaceuticals, Inc.
Major Depressive Disorder
This is a Phase 2B clinical study evaluating the effectiveness and safety of SP-624 as
compared to placebo in the treatment of adults with Major Depressive Disorder. expand
This is a Phase 2B clinical study evaluating the effectiveness and safety of SP-624 as compared to placebo in the treatment of adults with Major Depressive Disorder. Type: Interventional Start Date: Mar 2024 |
|
Study to Assess the Safety and Effectiveness of NMRA-335140-501
Neumora Therapeutics, Inc.
Major Depressive Disorder
This is a 52-week open-label extension (OLE) study that will evaluate the safety,
tolerability, and effectiveness of NMRA-335140 in participants with major depressive
disorder (MDD). Participants who completed a parent study investigating the efficacy and
safety of NMRA-335140 as a treatment for MD1 expand
This is a 52-week open-label extension (OLE) study that will evaluate the safety, tolerability, and effectiveness of NMRA-335140 in participants with major depressive disorder (MDD). Participants who completed a parent study investigating the efficacy and safety of NMRA-335140 as a treatment for MDD (ie, NMRA-335140-301, NMRA-335140-302, or NMRA-335140-303), and complete the 6 weeks double-blind treatment, provide informed consent, and meet eligibility criteria, may enter this extension study. Type: Interventional Start Date: Nov 2023 |
|
5-HTP and Creatine for Depression R33 Phase
University of Utah
Major Depressive Disorder
This is a three-armed clinical trial examining the effect of 5-hydroxytryptophan and
creatine monohydrate as augmenting agents for the treatment of depression. Subjects will
be randomized between 5-HTP 100mg BID + creatine 5g daily, 5-HTP 200mg BID + creatine 10g
daily, vs double placebo, for 8 wee1 expand
This is a three-armed clinical trial examining the effect of 5-hydroxytryptophan and creatine monohydrate as augmenting agents for the treatment of depression. Subjects will be randomized between 5-HTP 100mg BID + creatine 5g daily, 5-HTP 200mg BID + creatine 10g daily, vs double placebo, for 8 weeks. The ability of the interventions to affect biomarkers associated with depression will be assessed using brain phosphorus magnetic resonance spectroscopy, functional connectivity imaging, and plasma serotonin levels. Type: Interventional Start Date: Sep 2023 |
|
EPI-MINN: Targeting Cognition and Motivation - National
University of Minnesota
Psychosis
Psychosis Nos/Other
Schizophrenia
Schizo Affective Disorder
Schizoaffective Disorder
The purpose of this study is to perform a practice-based research project designed to
assess whether cognition and motivated behavior in early psychosis can be addressed as
key treatment goals within real-world settings by using a 12-week mobile intervention
program. We will recruit participants wh1 expand
The purpose of this study is to perform a practice-based research project designed to assess whether cognition and motivated behavior in early psychosis can be addressed as key treatment goals within real-world settings by using a 12-week mobile intervention program. We will recruit participants who are receiving care for early psychosis from clinics across the United States. We will compare outcomes from participants who receive treatment at coordinated specialty care (CSC) early psychosis clinics to those that receive standard community care. A qualifying CSC program will provide comprehensive clinical services such as psychotherapy, medication management, psychoeducation, and work or education support. This study will be conducted remotely, and participants can participate at home with their own electronic devices. The aim of this study is to investigate a well-defined 12-week mobile intervention program specifically designed to target cognitive functioning and motivated behavior for individuals with early psychosis. Participants will complete a screening interview which will include diagnosis and symptom ratings, neurocognitive assessment, and self-reports of symptoms, behavior, and functioning. Then participants will be randomized to receive the 12-week mobile intervention, or an active control of treatment as usual. The investigators will test for differences in the clinical trajectories after training, and at two follow up appointments at 6 and 12 months post-training. Type: Interventional Start Date: May 2023 |
|
A Study of Ketamine Infusions to Treat Clinically-depressed ICU Patients
Mayo Clinic
Depression
The purpose of this research is to study the effects of intravenous ketamine infusions
for the treatment of patients with depressive symptoms in intensive care unit (ICU). expand
The purpose of this research is to study the effects of intravenous ketamine infusions for the treatment of patients with depressive symptoms in intensive care unit (ICU). Type: Interventional Start Date: Jul 2025 |
|
A Novel Peer-Delivered Recovery-Focused Suicide Prevention Intervention for Veterans With Serious M1
VA Office of Research and Development
Psychotic Disorders
Bipolar Disorders
Suicidal Ideation
Suicide, Attempted
Suicide is a major public health concern, particularly among Veterans with serious mental
illness (SMI, i.e., psychotic disorders or bipolar disorders). Wellness Recovery Action
Plan (WRAP) is a well-established evidence-based practice for those with SMI that centers
on identifying warning signs of1 expand
Suicide is a major public health concern, particularly among Veterans with serious mental illness (SMI, i.e., psychotic disorders or bipolar disorders). Wellness Recovery Action Plan (WRAP) is a well-established evidence-based practice for those with SMI that centers on identifying warning signs of mental illness, developing wellness tools for functional independence, planning for day-to-day effective living within one's community, and building an action plan to create a valued life worth living. This proposed study will refine and pilot SUicide Prevention by Peers Offering Recovery Tactics (SUPPORT), a novel integrated recovery program that is an adaptation of peer-delivered WRAP for Veterans with SMI. In SUPPORT, a Peer Specialist leads a Veteran at increased risk for suicide through recovery planning that is tailored to the Veteran's suicidal experiences with cognitive learning strategies to enhance safety plan recall and improve functioning. Type: Interventional Start Date: Sep 2023 |
|
Testing Adaptive Interventions to Improve Posttraumatic Stress Disorder Treatment Outcomes in Feder1
University of Michigan
PTSD
This trial is being completed to develop a stepped-care talk therapy model for patients
with PTSD. Specifically, this study is testing whether beginning with one type of therapy
is better than beginning with another type of therapy, and whether moving to a different
therapy after four sessions is m1 expand
This trial is being completed to develop a stepped-care talk therapy model for patients with PTSD. Specifically, this study is testing whether beginning with one type of therapy is better than beginning with another type of therapy, and whether moving to a different therapy after four sessions is more helpful than staying with the same therapy, depending on how well it is working. The central hypothesis is that beginning with a low- or medium-intensity PTSD intervention and then titrating intensity based on early indications of response will result in clinically significant PTSD symptom reduction with parsimony of resources. Type: Interventional Start Date: Jun 2022 |
|
Decoding and Modulating Affective Brain States
University of Pennsylvania
Rumination
Major Depressive Disorder
Anxiety
The research study is being conducted to study brain patterns of negative emotion and
develop personalized brain stimulation protocols to disrupt these patterns with
transcranial magnetic stimulation (TMS). First, we will use functional Magnetic Resonance
Imaging (fMRI) data to generate a negative1 expand
The research study is being conducted to study brain patterns of negative emotion and develop personalized brain stimulation protocols to disrupt these patterns with transcranial magnetic stimulation (TMS). First, we will use functional Magnetic Resonance Imaging (fMRI) data to generate a negative affect map for each subject. Then, we will try a variety of repetitive transcranial magnetic stimulation (rTMS) sequences while inside the MRI scanner to determine the optimal and least optimal rTMS frequencies at changing negative affect brain states. Finally, these two frequencies will be tested over two 3-day rTMS neuromodulation sessions to see if they can reduce negative emotions. Type: Interventional Start Date: Feb 2023 |
|
Mental Health in Primary Care
University of Miami
Depression, Anxiety
Suicide
Drug Use
The goal of this study is to evaluate in an effectiveness-implementation type I hybrid
trial, an enhanced version of eHealth Familias Unidas for reducing depressive, anxious
symptoms and suicide behavior in Hispanic youth. The study will use a randomized rollout
design with 18 pediatric primary car1 expand
The goal of this study is to evaluate in an effectiveness-implementation type I hybrid trial, an enhanced version of eHealth Familias Unidas for reducing depressive, anxious symptoms and suicide behavior in Hispanic youth. The study will use a randomized rollout design with 18 pediatric primary care clinics in the South Florida area. Type: Interventional Start Date: Apr 2022 |
|
Treatments for Insomnia in Veterans With PTSD
VA Office of Research and Development
Insomnia
PTSD
This randomized trial will compare a novel treatment, Acceptance of the Behavioral
Changes to Treat Insomnia (ABC-I) to Cognitive Behavioral Therapy for Insomnia (CBT-I)
among Veterans with comorbid Post-Traumatic Stress Disorder (PTSD) and insomnia disorder.
ABC-I combines the behavioral component1 expand
This randomized trial will compare a novel treatment, Acceptance of the Behavioral Changes to Treat Insomnia (ABC-I) to Cognitive Behavioral Therapy for Insomnia (CBT-I) among Veterans with comorbid Post-Traumatic Stress Disorder (PTSD) and insomnia disorder. ABC-I combines the behavioral components of CBT-I with components of another behavioral therapy (Acceptance and Commitment Therapy) and has been shown to improve treatment adherence. The study objectives are: 1) to evaluate the benefits of ABC-I in reducing post-traumatic stress disorder (PTSD) symptoms among Veterans with comorbid PTSD and insomnia disorder compared to CBT-I, and 2) to evaluate the effectiveness of ABC-I in improving insomnia symptoms and sleep quality among Veterans with comorbid PTSD and insomnia disorder as compared to CBT-I. Veterans with insomnia and comorbid PTSD who receive care at Sepulveda and West Los Angeles facilities will be recruited for the study. Those who pass an initial eligibility screen will be enrolled and written informed consent will be obtained. A baseline assessment will be completed that includes measures of sleep, PTSD, and quality of life. Veterans who meet all eligibility criteria will be randomly assigned to the ABC-I (n=100) or CBT-I (n=100) treatment. Both treatments will be provided in 5 one-on-one sessions by a trained instructor who is supervised by a behavioral sleep medicine specialist. All randomized participants (n=200) will have 3 follow-up assessments (post-treatment, 3-months, and 6-months after randomization). The follow-up assessments will collect information on PTSD symptoms, insomnia symptoms and sleep quality. Type: Interventional Start Date: Sep 2022 |
|
Mechanisms of Rumination Change in Adolescent Depression
Ohio State University
Major Depressive Disorder
Mood Disorders
This study will evaluate whether a newer treatment, rumination-focused cognitive
behavioral treatment, which includes mindfulness and can be used to reduce ruminative
habits, change ways in which key brain regions interact with each other (e.g.., often
called connectivity), and whether these change1 expand
This study will evaluate whether a newer treatment, rumination-focused cognitive behavioral treatment, which includes mindfulness and can be used to reduce ruminative habits, change ways in which key brain regions interact with each other (e.g.., often called connectivity), and whether these changes in habits and brain connectivity can reduce the risk for recurrence of depression in the next two years. Type: Interventional Start Date: May 2019 |
|
Transcranial Direct Current Stimulation for Depression
Soterix Medical
Unipolar Depression
This study will test the efficacy of transcranial direct current stimulation (tDCS)
combined with mindfulness, remotely-delivered using a telemedicine protocol in 25 adults
with unipolar depression. expand
This study will test the efficacy of transcranial direct current stimulation (tDCS) combined with mindfulness, remotely-delivered using a telemedicine protocol in 25 adults with unipolar depression. Type: Interventional Start Date: Jul 2025 |
|
RCT for Latina Mental Health Using Web-Based Apps
University of California, Los Angeles
Mental Health
Anxiety
Depression
Well-Being, Psychological
This study compares a choice-driven, interactive, evidence-informed storytelling
web-based app intervention with links to resources and treatment (Tx) recommendations
(made by a character via her blog) and Tx locator, to a web-based app with links to
publicly available informational internet videos1 expand
This study compares a choice-driven, interactive, evidence-informed storytelling web-based app intervention with links to resources and treatment (Tx) recommendations (made by a character via her blog) and Tx locator, to a web-based app with links to publicly available informational internet videos, MH resources, and a treatment locator for at least moderately anxious/depressed untreated English and Spanish speaking Latinas to determine if a story-based, character-driven approach is more effective for catalyzing mental health treatment initiation. Type: Interventional Start Date: Jun 2025 |
|
Application of Virtual Reality Technology to Treatment of Social Anxiety
The University of Texas Health Science Center, Houston
Autism Spectrum Disorder
Social Anxiety Disorder
The purpose of this study is to compare CBT VR exposure + VR social skills treatment to
CBT Imaginal exposure + mindfulness, in reducing the severity of social anxiety in adults
with autism and social anxiety (SA), to identify characteristics associated with
benefitting from the CBT-VR treatment an1 expand
The purpose of this study is to compare CBT VR exposure + VR social skills treatment to CBT Imaginal exposure + mindfulness, in reducing the severity of social anxiety in adults with autism and social anxiety (SA), to identify characteristics associated with benefitting from the CBT-VR treatment and to assess acceptability and feasibility of the VR intervention for patients receiving it and use findings to improve methods and to prepare for a community based pragmatic trial. Type: Interventional Start Date: Nov 2024 |
|
A Study to Explore the Efficacy of JNJ-89495120 in the Treatment of Major Depressive Disorder
Janssen Research & Development, LLC
Depressive Disorder, Major
The purpose of this study is to evaluate how well JNJ-89495120 works (anti-depressant
effects) and how well it is tolerated as compared to placebo on reducing the symptoms of
depression in participants with major depressive disorder (MDD). expand
The purpose of this study is to evaluate how well JNJ-89495120 works (anti-depressant effects) and how well it is tolerated as compared to placebo on reducing the symptoms of depression in participants with major depressive disorder (MDD). Type: Interventional Start Date: Dec 2024 |
|
Suvorexant for Treatment of AUD and PTSD
Pharmacotherapies for Alcohol and Substance Use Disorders Alliance
Alcohol Use Disorder (AUD)
Post Traumatic Stress Disorder (PTSD)
Insomnia
This study is to determine if suvorexant (SUV) will reduce insomnia in 76 men and women
veteran and non-veterans between the ages 21-65 with posttraumatic stress disorder (PTSD)
symptoms and alcohol use disorder (AUD). All participants will have a 7-day placebo
run-in period, followed by a random a1 expand
This study is to determine if suvorexant (SUV) will reduce insomnia in 76 men and women veteran and non-veterans between the ages 21-65 with posttraumatic stress disorder (PTSD) symptoms and alcohol use disorder (AUD). All participants will have a 7-day placebo run-in period, followed by a random assignment to receive placebo or suvorexant for an additonal 14 days. Post-randomization, participants will attempt to stop drinking for two weeks and will complete daily virtual diaries and study outcome assessments via in-person clinic visits on days 7 and 14. Type: Interventional Start Date: Jul 2025 |
|
A Ketamine-assisted Group Therapy Intervention for Spanish-speaking Adults With Depression
Juliana Zambrano, MD, MPH
Depression
This is a pilot clinical trial to assess the feasibility, safety, and preliminary
efficacy of ketamine-assisted group therapy for Spanish-speaking adults with depression expand
This is a pilot clinical trial to assess the feasibility, safety, and preliminary efficacy of ketamine-assisted group therapy for Spanish-speaking adults with depression Type: Interventional Start Date: Jul 2025 |
|
Accelerated rTMS for Substance Use Disorder and Depression
University of Texas Southwestern Medical Center
Stimulant Use
Depression
This study is a small open-label feasibility trial of an accelerated course of repetitive
transcranial magnetic stimulation (rTMS) for individuals with depression and stimulant
use disorder [including methamphetamine or cocaine use disorder (MUD/CUD)]. expand
This study is a small open-label feasibility trial of an accelerated course of repetitive transcranial magnetic stimulation (rTMS) for individuals with depression and stimulant use disorder [including methamphetamine or cocaine use disorder (MUD/CUD)]. Type: Interventional Start Date: Jun 2024 |
|
Efficacy and Safety Study of BHV-7000 Monotherapy in Major Depression
Biohaven Therapeutics Ltd.
Major Depressive Disorder
The purpose of this study is to determine the efficacy and safety of BHV-7000 in
participants with Major Depressive Disorder (MDD) expand
The purpose of this study is to determine the efficacy and safety of BHV-7000 in participants with Major Depressive Disorder (MDD) Type: Interventional Start Date: May 2024 |
|
Optimizing Suicide Prevention Strategies for Pediatric Primary Care
University of Pittsburgh
Suicidal Ideation
Suicidal and Self-injurious Behavior
Depression
Increasing rates of suicidal thoughts and behaviors among adolescents must be addressed.
The study will adapt and collect preliminary effectiveness data on a digital suicide
prevention intervention that can be delivered in pediatric primary care settings by front
line pediatricians. The study has t1 expand
Increasing rates of suicidal thoughts and behaviors among adolescents must be addressed. The study will adapt and collect preliminary effectiveness data on a digital suicide prevention intervention that can be delivered in pediatric primary care settings by front line pediatricians. The study has the potential to offer a low-cost and scalable primary care intervention that may decrease risk of suicide among at-risk youth. Type: Interventional Start Date: Jun 2025 |
