Evaluation of the Genetics of Bipolar Disorder
Purpose
This study looks to identify genes that may affect a person's chances of developing bipolar disorder (BP) and related conditions.
Condition
- Bipolar Disorder
Eligibility
- Eligible Ages
- Between 18 Years and 100 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
Age > 18 yr Able to provide informed consent Bipolar disorder or related conditions not attributable to substance abuse, neurological disease; or a 1st or 2nd degree relative of an enrolled participant. Related conditions are defined as those found more often among relatives of people with bipolar disorder or which have been shown to be genetically correlated with bipolar disorder through molecular genetic studies. These include major depression, schizophrenia, panic disorder, and attention deficit hyperactivity disorder. Able to safely provide a blood or saliva sample
Exclusion Criteria
Active alcohol or substance abuse. NIMH employees/staff and their immediate family members will be excluded from the study per NIMH policy.
Study Design
- Phase
- Study Type
- Observational
- Observational Model
- Family-Based
- Time Perspective
- Cross-Sectional
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
| Healthy Volunteers | Healthy volunteers | |
| Patients | Patients with bipolar disorder |
Recruiting Locations
More Details
- Status
- Recruiting
- Sponsor
- National Institute of Mental Health (NIMH)
Detailed Description
Bipolar affective disorder is a severe, heritable condition affecting about one percent of the population. The mode of inheritance is poorly understood and probably involves multiple loci of small to moderate effect. In this project, we use genetic mapping and sequencing methods to identify genetic markers and variations that contribute to the risk of bipolar disorder. Individuals diagnosed with bipolar disorder are studied, along with their relatives. Phenotypic information obtained from clinical interviews and family history is correlated with genotypic information obtained from genetic marker and sequencing methods. The goal is to identify genes involved in bipolar disorder and related conditions so that better methods of diagnosis, treatment, and prevention can be developed.
