Transdiagnostic Cognitive Biomarkers

Purpose

The overall objective of this study is to determine the feasibility of identifying transdiagnostic biomarkers of cognitive function mediated by neuromodulation of the dorsolateral prefrontal cortex that are translatable across disease groups in order to more accurately phenotype clusters of cognitive dysfunction. Completing behavioral paradigms with electrophysiology and TMS is a challenging frontier. This study focuses on the feasibility of such an endeavor for those with chronic pain or depression as well as healthy controls.

Conditions

  • Pain
  • Depression

Eligibility

Eligible Ages
Over 18 Years
Eligible Genders
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Have access to the online study platform.

Exclusion Criteria

  • under 18, non-English speaking Arm 2: pain and depression: Inclusion Criteria: - Pain or depression Exclusion Criteria: - pregnant women

Study Design

Phase
N/A
Study Type
Interventional
Allocation
Non-Randomized
Intervention Model
Single Group Assignment
Intervention Model Description
Feasibility study
Primary Purpose
Diagnostic
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Active Comparator
Healthy Comparison Group
Behavioral tasks and surveys online.
  • Behavioral: Computer game/task
    N-back, COGED, PacMan game, Bandit task, Websurf task.
    Other names:
    • Behavioral tasks online and in-person.
  • Behavioral: Health surveys online
    Health surveys to study themes like pain, sleep, depression and anxiety, and PTSD.
    Other names:
    • PHQ-9, MASQ, GAD-7
Experimental
Pain/Depression patients from clinic
MRI, TMS and EEG, and behavioral tasks and surveys online.
  • Behavioral: Computer game/task
    N-back, COGED, PacMan game, Bandit task, Websurf task.
    Other names:
    • Behavioral tasks online and in-person.
  • Behavioral: Health surveys online
    Health surveys to study themes like pain, sleep, depression and anxiety, and PTSD.
    Other names:
    • PHQ-9, MASQ, GAD-7

Recruiting Locations

More Details

Status
Recruiting
Sponsor
University of Minnesota

Study Contact

David Darrow
(612) 624-6666
hdlab@umn.edu

Detailed Description

This study aims to test the feasibility of procedures aimed at discovering transdiagnostic biomarkers for cognitive impairment in chronic pain and depression. Fifteen healthy control participants and 15 participants from each disease group (chronic pain, depression) will be recruited. Using a task-based fmri, TMS will be targeted for priming of the Left DLPFC. EEG will be used during our behavioral paradigm to compare changes in DLPFC function before and after primed TMS.