Intracranial Neurophysiological Signatures of Fear and Anxiety in Humans
Purpose
Anxiety disorders such as post-traumatic stress disorder (PTSD) and generalized anxiety disorder (GAD) affect a large number of individuals with a significant portion of patients failing to improve with current treatments. The purpose of this study is to understand the brain mechanisms that produce fear and anxiety in humans. To accomplish this goal, we will measure the brain activity along with the heart rate and skin perspiration of patients while they are completing tasks on a computer. Some of the tasks will also use a virtual reality headset and transport the patient in a video game-like environment. These tasks will expose the participants to various levels of fear-provoking images.
Conditions
- Fear
- GAD
- Emotional Memory
- PTSD
Eligibility
- Eligible Ages
- Between 18 Years and 90 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- 18 years of age or older - Has undergone acute depth or chronic responsive neurostimulation (RNS) electrode placement - Willing to provide informed consent and participate in the study - Ability to read and write English fluently
Exclusion Criteria
- Unwilling to provide informed consent - Not a native English Speaker - Has not undergone acute depth or chronic responsive neurostimulation (RNS) electrode placement - Pregnant women - Participants with active psychosis - Participants with suicidal ideation - Participants with substance abuse issues
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- N/A
- Intervention Model
- Single Group Assignment
- Primary Purpose
- Basic Science
- Masking
- Double (Participant, Investigator)
Recruiting Locations
More Details
- Status
- Recruiting
- Sponsor
- University of California, Los Angeles
