Preventing the Development of Chronic Pain: Treating PTSD at Acute Pain Onset
Purpose
Although most people recover from acute pain (such as pain caused by injury, surgery, repetitive motion, or unknown causes), many people do not fully recover and will experience chronic pain. Untreated posttraumatic stress disorder (PTSD) appears to be a key risk factor for the transition from acute pain to chronic pain. However, few published studies have addressed the issue of preventing the transition from acute to chronic pain via PTSD reduction. This project will aim to test whether trauma-related PTSD symptoms can be reduced using either Stellate Ganglion Block (SGB) treatment or Cognitive Processing Therapy (CPT), and whether reducing PTSD symptoms can prevent the transition from non-injury based acute pain to chronic pain.
Conditions
- PTSD
- Chronic Pain
Eligibility
- Eligible Ages
- Between 18 Years and 70 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Age 18 to 70 years 2. Ability to read and write English sufficiently to understand and complete study questionnaires and participate in interviews 3. Presenting to the Rush Emergency Department (ED) with a medical problem and experiencing non-injury based acute pain 4. A primary acute pain site 5. self-reported symptoms consistent with a diagnosis of PTSD. 6. People with well-controlled diabetes or HIV/AIDS will be included only if there is no self-reported history of chronic or neuropathic pain on presentation to the ED or documented in the electronic medical record.
Exclusion Criteria
- pain intensity great enough to impair concentration or capacity to understand instructions or the nature of being invited into a study as assessed by a member of the medical staff 2. any injury or illness that precludes their ability to understand or follow instructions as assessed by a member of the medical staff 3. current chronic illness that involves constant or frequent pain 4. self-reported history of chronic pain on presentation to the ED or documented in the electronic medical record 5. pain from traumatic event that is the source of their PTSD 6. neurological disorder 7. blood pressure greater than 160/100 mmHg 8. Taking anticoagulants or antiplatelet drugs other than aspirin 9. pregnancy 10. current or lifetime psychotic or bipolar disorders 11. current alcohol or substance dependence 12. anything that precludes interventions from being successful. We will exclude people who are being treated for chronic or significant diseases such as rheumatoid disease, current influenza that may manifest temporary flu- related pain, and heart disease.
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Treatment
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Active Comparator Stellate Ganglion Block Treatment |
Participants randomly assigned to the Stellate Ganglion Block (SGB) condition will receive 2 SGB treatments separated by 2 weeks. |
|
|
Active Comparator Cognitive Processing Therapy |
Participants randomly assigned to the Cognitive Processing Therapy (CPT) condition will receive 1-week massed CPT treatment consisting of 10 CPT sessions given within a single 5-day period via telehealth. |
|
|
No Intervention Usual Care |
Participants randomly assigned to the Usual Care condition will not receive any active intervention. |
|
Recruiting Locations
More Details
- Status
- Recruiting
- Sponsor
- Rush University Medical Center
Detailed Description
Untreated PTSD appears to be a key risk factor for the transition from acute pain to chronic pain. Thus, reducing PTSD symptoms during an acute pain episode may potentially decrease the likelihood of transitioning to chronic pain. CPT is an evidence-based trauma-focused cognitive behavioral treatment that is hypothesized to reduce PTSD symptoms via reducing negative trauma-related cognitions about oneself, others, and the world. SGB treatment is an injection of a local anesthetic into the stellate ganglion, which is a bundle of nerves located at the base of the neck that is part of the sympathetic nervous system. Previous studies suggest that 1-week massed CPT and SGB treatment can both reduce the severity of PTSD symptoms in short periods of time via two distinct psychological and biological mechanisms. This 4 year project will test study hypotheses in a sample of 345 individuals with PTSD symptoms who present to the presenting to the Rush University Medical Center ED or Rush's Primary Care and Preventative Medicine group with non-injury based acute pain. Participants will be randomly assigned to receive 1-week massed CPT, 2 SGB treatments, or usual care. All participants will complete identical self-report and/or clinician administered assessments at baseline (prior to randomization) and on study days 1, 7, 14, 21, 28, 56 (approximately 3 months after the initial ED presentation or Presentation to Preventative Medicine), and 112 (approximately 6 months after ED presentation or presentation to Preventative Medicine).
