Neurofeedback Enhanced Cognitive Reappraisal Training
Purpose
This study seeks to understand emotion regulation in those with anxiety using real-time functional magnetic resonance imaging neurofeedback, a tool that allows individuals to control brain activity. The goal of this project is to understand how receiving feedback about one's own brain activity relates to emotion regulation ability. This work will help the study team understand the brain areas involved in emotion regulation and could lay the groundwork to test if psychotherapy outcomes can be enhanced using neurofeedback. The study hypotheses include: - Participants receiving veritable-Neurofeedback (NF) will show a greater activation increase in the prefrontal cortex (PFC) compared to sham-NF - Participants receiving veritable-NF will show greater cognitive reappraisal (CR) ability compared to those receiving sham-NF - Prefrontal cortex activation will positively correlate with CR ability
Conditions
- Anxiety
- Social Anxiety Disorder
- Panic Disorder
- Generalized Anxiety Disorder
Eligibility
- Eligible Ages
- Between 18 Years and 55 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Primary diagnosis (primary source of distress and/or interference) of generalized anxiety disorder, social anxiety disorder, panic disorder or illness anxiety disorder based on structured interview. Comorbid phobic disorders allowed, but these cannot be the primary source of interference or distress due to the lowered chances of encountering anxiety-provoking stimuli during the study period - Medically and physically able to consent - Not taking any medication, prescription or non-prescription with psychotropic effects other than birth control or antidepressant (i.e., selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI) with stable dosage for past 4 week - For females, not currently pregnant or actively trying to become pregnant - Ability to tolerate small, enclosed spaces without anxiety - No metals, implants or metallic substances within or on the body that might cause adverse effects to the subject in a strong magnetic field, or interfere with image acquisition (per protocol) - Size compatible with scanner gantry (per protocol)
Exclusion Criteria
- Current diagnosis of Obsessive Compulsive Disorder or Posttraumatic Stress Disorder - Current course of individual or group psychotherapy - Current substance abuse or dependence (past 6 months) - Active suicidality with plan or intent - Current psychosis - History of serious neurological illness or current medical condition that could compromise brain function, such as liver failure - History of closed head injury, e.g., loss of consciousness greater (>) approximately (~) 5 minutes, hospitalization, neurological sequela
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Basic Science
- Masking
- Double (Participant, Care Provider)
- Masking Description
- All staff present during the MRI session, as well as the participant, will be blinded to group assignment. The Study Coordinator will remain unblinded during the duration of the study.
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Veritable-NF |
|
|
|
Active Comparator Sham-NF |
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Recruiting Locations
More Details
- Status
- Recruiting
- Sponsor
- University of Michigan
