Positive Affect Treatment for Adolescents With Early Life Adversity
Purpose
Youth exposed to early life adversity (ELA) are known to be at greater risk for depression and suicidality and account for almost half of the youth suffering from psychiatric diseases today. Youth exposed to ELA consistently report symptoms of anhedonia as well as dysregulated positive affect. The present project will test the efficacy of PAT in a sample of ELA-exposed adolescents in order to determine whether PAT increases positive affect, and subsequently symptoms of depression. For this pilot, the investigators will recruit 22 adolescents exposed to two or more childhood adversities (ACEs) who do not currently have major depressive disorder, and randomize them (1:1) to either participate in PAT or a waitlist control condition. At study enrollment, then 4-, 8, and 12-months thereafter the investigators will measure positive affect and depressive symptoms (including anhedonia). The results of this study will be used to inform whether PAT has the potential to prevent major depressive episodes among adversity-exposed youth.
Condition
- Depression
Eligibility
- Eligible Ages
- Between 12 Years and 16 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- aged 12-16 - exposed to 2 or more adverse childhood experiences (ACEs)
Exclusion Criteria
- currently taking an antidepressant or any medications known to influence immune functioning on a daily basis (e.g., steroidal medications to treat asthma or allergies) - current or past history of manic or psychotic symptoms - parent-reported diagnosis of intellectual disability or autism spectrum disorder - chronic medical conditions (e.g., cancer, rheumatoid arthritis, diabetes, multiple sclerosis), - bleeding disorders such as hemophilia
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover Assignment
- Intervention Model Description
- Participants will be randomized 1:1 to either receive PAT upon enrollment or after a waitlist period.
- Primary Purpose
- Prevention
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Positive affect treatment |
PAT is a 15-week cognitive-behavioral therapy that focuses on increasing reward motivation and sensitivity at the neural, behavioral, and affective levels of analysis. These observed effects occur through PAT's effects on reward sensitivity and positive affect. Participants will be assigned to a therapist with training in cognitive-behavioral therapy who will meet with them weekly via telehealth. |
|
|
No Intervention Waitlist |
|
Recruiting Locations
More Details
- Status
- Recruiting
- Sponsor
- University of California, Irvine
