FMRI Accelerated TMS Depression
Purpose
This study aims to investigate whether phenotypic-related brain states revealed by a novel INSCAPE ("Individualized Network-based Single-frame Coactivation Pattern Estimation") neuroimaging method in Major Depressive Disorder (MDD) patients can track brain recovery of MDD patients over an accelerated antidepressant transcranial magnetic stimulation (TMS) treatment.
Condition
- Depression
Eligibility
- Eligible Ages
- Between 18 Years and 65 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Age 18-65 - Have the capacity and ability to provide one's own consent in English and sign the informed consent document. - DSM-IV diagnosis of MDD
Exclusion Criteria
- Unable to speak English. - Contraindicated for MRI. - Any current or recent untreated medical, neurological, or psychiatric conditions - Metal implant devices in the head, heart, or neck. - History of brain surgery. - History of cortisol medication use or electroconvulsive therapy. - Comorbidity with other psychiatric/neurological illnesses or personality disorders - History of myocardial infarction or arrhythmia, bradycardia. - Personal history of head injury, concussion, or self-report of moderate to severe traumatic brain injury. - Individuals suffering from frequent/severe headaches. - Moderate to severe alcohol or substance use disorder. - Pregnancy
Study Design
- Phase
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
| Volunteer Participants with Major Depressive Disorders (MDD) | 20 patients with MDD receiving 5-day accelerated transcranial magnetic stimulation therapy (TMS) from the clinic will be recruited to participate in this observational neuroimaging study. Participants will undergo two fMRI scans at baseline and post-treatment. |
|
Recruiting Locations
More Details
- Status
- Recruiting
- Sponsor
- Medical University of South Carolina
Detailed Description
The aim of this study is to use magnetic resonance imaging (MRI) to capture images of participants' brains and apply an image processing method called INSCAPE to assess brain states. This study will recruit participants who are scheduled to receive accelerated Transcranial Magnetic Stimulation (TMS) therapy for Major Depressive Disorder (MDD). Participation in this study involves two visits, each including a 30-minute MRI scan. The interval between each visit is about one week. Depressed participants will also complete mood assessments at various intervals while they are receiving accelerated TMS for depression.
