Visual Perception in Schizophrenia
Purpose
This study aims to identify novel markers of psychosis using electroencephalography (EEG).
Conditions
- Schizophrenia Disorders
- Bipolar Disorder
- Schizo Affective Disorder
Eligibility
- Eligible Ages
- Between 18 Years and 65 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- All Subjects - Aged 18-65 - 20/32 visual acuity or better (using in-house optical correction, if necessary) - An ability to speak English well enough to complete study assessments and to consent to the study - Subjects with Schizophrenia-Spectrum Disorder - Meets DSM-5 diagnostic criteria for schizophrenia, schizoaffective disorder, or schizophreniform disorder as confirmed by the Structured Interview for DSM-5 (SCID-5). - Subjects with Bipolar Disorder - Meets DSM-5 diagnostic criteria for bipolar disorder (type I, II, or unspecified) as confirmed by the Structured Interview for DSM-5 (SCID-5).
Exclusion Criteria
- All subjects - Presence of characteristics that could impair one's ability to comprehend the nature of the study, provide informed consent, or understand the assessment questions, including the following: - Subject cannot read and understand the instructions well enough to complete the tasks or cannot provide informed consent. - Intellectual impairment (WRAT-5 score < 70) (at the discretion of experimenter); - Actively intoxicated, as shown via patient self-report or staff report; - Substance use disorder in the past 3 months; - Subject considered high risk for suicidal acts (i.e., active suicidal ideation as determined by clinical interview OR any suicide attempt in 30 days prior to screening); - Subject violence (involving severe/lethal means or violence occurring in prior 6 months) or extreme agitation. - Being in a current manic state - Head injury with loss of consciousness greater than 10 minutes (at the discretion of the experimenter). - Subject has had electroconvulsive therapy (ECT) in the past 8 weeks; - Diagnosed with a neurological condition (tumor, stroke, brain injury) or neurological disorder, including seizure disorders. Diagnosed with pervasive developmental disorder (phone screen or medical records) - Lazy eye or squint or other known ocular pathology - Healthy Control Subjects - Any lifetime psychotic disorder or history of psychiatric hospitalization (self disclosure); - Daily antidepressant, mood stabilizer or antipsychotic medication use in the last 6 months, or benzodiazepine use during the prior 2 days (self-disclosure); iii. First-degree relative(s) with a schizophrenia spectrum disorder (based on subject self-report) or bipolar disorder. - Case-match Control Non-ill Subjects - Any lifetime psychotic disorder (as assessed by SCID/or SSD); - Recurrent depressive episodes or being in a current depressive episode (as assessed by SCID/or SSD) - Persistent threshold psychotic symptoms - History of psychiatric hospitalization; - Daily antidepressant, mood stabilizer or antipsychotic medication use in the last 6 months, or benzodiazepine use during the prior 2 days - First-degree relative(s) with a schizophrenia spectrum disorder (based on subject self-report) or bipolar disorder. - Bipolar Subjects - Persistent threshold psychotic symptoms
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- N/A
- Intervention Model
- Single Group Assignment
- Primary Purpose
- Basic Science
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental All participants |
|
Recruiting Locations
More Details
- Status
- Recruiting
- Sponsor
- University of Rochester
