Cognitive Processing Therapy (CPT) for Perinatal Posttraumatic Stress Disorder (PTSD)

Purpose

Pregnant women with a primary diagnosis of posttraumatic stress disorder (PTSD) (PTSD Checklist for DSM-5 (PCL-5) score > 33) will be randomized to receive conventional cognitive processing therapy (CPT) (60-min session once/week for 12 weeks) or massed CPT (mCPT) (an intensive schedule of 12 60-min sessions over 5 days, approximately 2-3 sessions per day) via telemedicine, for treatment of PTSD. The research aims will be three-fold: (1) Evaluate the relative efficacy and tolerability of CPT vs. mCPT for treatment of perinatal PTSD and depression; (2) Determine the effect of CPT upon maternal-infant attachment and interaction; (3) Collect pilot data of obstetric and neonatal outcomes among those receiving the two CPT delivery schedules.

Conditions

  • Posttraumatic Stress Disorder (PTSD)
  • Pregnancy

Eligibility

Eligible Ages
Between 18 Years and 46 Years
Eligible Sex
Female
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Female, ages 18-46, Pregnant (< 25 weeks), able to read and write in English, History of at least 1 criterion A trauma, Primary diagnosis of PTSD (confirmed by SCID), Psychotropic medications must be stable with no changes ≥ 2 weeks (≥ 6 weeks for fluoxetine), and no medication changes can be made during the course of therapy

Exclusion Criteria

  • Not currently pregnant, Diagnosis of bipolar disorder, psychotic disorders, Suicidal ideation with plan or intent, Substance use disorder, Regular benzodiazepine use (> 4x weekly)

Study Design

Phase
N/A
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Regular CPT
Standard-model Cognitive Processing Therapy (CPT) - one 60-min session per week for 12 weeks total
  • Behavioral: Regular CPT
    Standard-model Cognitive Processing Therapy (CPT) - one 60-min session per week for 12 weeks total
Experimental
mCPT
Massed CPT - two 60-min sessions each day for 5 consecutive days (10 sessions total)
  • Behavioral: Massed CPT
    Massed CPT - two 60-min sessions each day for 5 consecutive days (10 sessions total)

Recruiting Locations

More Details

Status
Recruiting
Sponsor
University of Texas at Austin

Study Contact

Research Associate I
512-766-6209
ambreen.rana@austin.utexas.edu