Glucose Variability and Cognition in Prediabetes
Purpose
This study examines the association of variability in glucose values over a 10-day period with cognitive function and functional status among individuals with prediabetes, aged 50 or older.
Conditions
- Glucose Metabolism Disorders (Including Diabetes Mellitus)
- Cognitive Decline
- Functional Status
- PreDiabetes
- Aging
- Depression
Eligibility
- Eligible Ages
- Over 50 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Aged 50 years and older - At least 8th grade education
Exclusion Criteria
- Diagnosed type 1 or type 2 diabetes - Current use of mediation for diabetes (oral hypoglycemic agents, insulin), or with diabetic properties (e.g., steroids) - Chronic disorders (cardiovascular disease, peripheral vascular disease, stroke, transient ischemic attack, chronic kidney disease, past year cancer) - Neurological disorders (e.g., Parkinson's, epilepsy, multiple sclerosis) - History of dementia or suspected dementia - Known HIV - Serious mental illness, psychosis, or use of psychotropic medication - Heavy alcohol use
Study Design
- Phase
- Study Type
- Observational
- Observational Model
- Ecologic or Community
- Time Perspective
- Cross-Sectional
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
| Middle-aged and Older adults with Prediabetes | Middle-aged and Older adults with Prediabetes |
|
Recruiting Locations
More Details
- Status
- Recruiting
- Sponsor
- University of Maryland, Baltimore
Detailed Description
Type 2 diabetes (T2DM) is now widely considered a major public health epidemic. T2DM is highly prevalent worldwide, is among the leading causes of death, and is an independent risk factor for dementia and less severe forms of cognitive dysfunction. The investigators are utilizing novel technology to understand the role of variability in glucose on neurocognition and functional status among middle-aged and older adults at risk for diabetes. The central hypothesis is that even before diabetes onset, variability in glucose will be associated with worse cognitive function and lower functional status. Participants will be asked to wear a glucose monitoring device over a 10-day period in their home environment. Assessment of functional status and neurocognitive function, in addition to sociodemographic factors, health habits and mood will also occur over two study visits.
