Anxiety & Depression Association of America

Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations

Purpose

Conditions

Traumatic Brain Injury
Major Depressive Disorder
Bipolar Disorder
Schizophrenia
Attention Deficit Hyperactivity Disorder
Borderline Personality Disorder
Substance Use Disorders

Eligibility

Eligible Ages: Between 18 Years and 65 Years
Eligible Genders: All
Accepts Healthy Volunteers: Yes

Inclusion Criteria

Male and female outpatients 18-65 years of age 2. A diagnosis of traumatic brain injury, major depressive disorder, bipolar disorder, schizophrenia, attention deficit hyperactivity disorder, borderline personality disorder and substance use disorders meeting the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria.

Exclusion Criteria

Contraindication to tDCS: history or epilepsy, metallic implants in the head and neck, brain stimulators, vagus nerve stimulators, shunts, pacemakers, pregnancy. 2. Active substance dependence (except for tobacco and cannabis). 3. Pregnant or nursing females. 4. Inability to participate in testing procedures. 5. Additional exclusion criteria for healthy controls: 1. Diagnosis of psychiatric of neurological disorder 2. Ongoing treatment with any psychotropic medications.

Study Design

Phase: N/A
Study Type: Interventional
Allocation: Randomized
Intervention Model: Parallel Assignment
Primary Purpose: Treatment
Masking: Single (Participant)

Arm Groups

Arm	Description	Assigned Intervention
Experimental Traumatic Brain Injury	This group consists of individuals diagnosed with traumatic brain injury. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized.	Device: Transcranial Direct Current Stimulation In tDCS, electrodes are applied on the scalp to transmit direct current at low current amplitudes. Other names: tDCS
Experimental Major Depressive Disorder	This group consists of individuals diagnosed with major depressive disorder. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized.	Device: Transcranial Direct Current Stimulation In tDCS, electrodes are applied on the scalp to transmit direct current at low current amplitudes. Other names: tDCS
Experimental Bipolar Disorder	This group consists of individuals diagnosed with bipolar disorder. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized.	Device: Transcranial Direct Current Stimulation In tDCS, electrodes are applied on the scalp to transmit direct current at low current amplitudes. Other names: tDCS
Experimental Schizophrenia	This group consists of individuals diagnosed with schizophrenia. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized.	Device: Transcranial Direct Current Stimulation In tDCS, electrodes are applied on the scalp to transmit direct current at low current amplitudes. Other names: tDCS
Experimental Attention Deficit Hyperactivity Disorder	This group consists of individuals diagnosed with attention deficit hyperactivity disorder. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized.	Device: Transcranial Direct Current Stimulation In tDCS, electrodes are applied on the scalp to transmit direct current at low current amplitudes. Other names: tDCS
Experimental Borderline Personality Disorder	This group consists of individuals diagnosed with borderline personality disorder. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized.	Device: Transcranial Direct Current Stimulation In tDCS, electrodes are applied on the scalp to transmit direct current at low current amplitudes. Other names: tDCS
Experimental Substance Use Disorder	This group consists of individuals diagnosed with substance use disorder. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized.	Device: Transcranial Direct Current Stimulation In tDCS, electrodes are applied on the scalp to transmit direct current at low current amplitudes. Other names: tDCS
Active Comparator Healthy Controls	This group consists of individuals diagnosed with healthy controls. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized.	Device: Transcranial Direct Current Stimulation In tDCS, electrodes are applied on the scalp to transmit direct current at low current amplitudes. Other names: tDCS

Recruiting Locations

More Details

Status: Recruiting
Sponsor: Massachusetts General Hospital

Study Contact

Joan Camprodon, MD, PhD, MPH
6177265348

Detailed Description

In the current study, the investigators aim to understand the role of transcranial direct current stimulation (tDCS) in improving executive function across neuropsychiatric populations known to have deficits in this cognitive domain. The investigators will select 8 relevant diagnostic categories: traumatic brain injury, major depressive disorder, bipolar disorder, schizophrenia, attention deficit hyperactivity disorder, borderline personality disorder and substance use disorder. The study will also include a cohort of healthy controls for comparison.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.