Dose-Response Effect Exercise and Depression
Purpose
The present study aims to address gaps in the literature by evaluating the objectively measured dose-response relationship between exercise and depression symptoms; examining changes in resting (Brain-derived Neurotrophic Factor) BDNF from baseline to week 10 of an exercise intervention; and assessing varying exercise intensities on enjoyment, affect, and health-related quality of life in sedentary young adult college students.
Condition
- Depression
Eligibility
- Eligible Ages
- Between 18 Years and 25 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- enrolled UCF college students aged 18 to 25 - mild to moderate depressive symptoms - willing to wear a Fitbit for extended periods of time during the study - willing to participate in moderate-to-vigorous PA - physically able to participate in exercise safely
Exclusion Criteria
- under 110 lbs - history of bad reaction to a past blood draw - have been advised by a medical provider to not give/donate blood - presence of anemia - current cognitive therapy or antidepressant medication - diagnosis of a co-occurring condition such as attention deficit hyperactivity disorder (ADHD) - diagnosis of a serious mental illness (SMI) such as schizophrenia or bipolar disorder - pregnant or nursing - current smoker - beta-blocker medications
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Supportive Care
- Masking
- Single (Outcomes Assessor)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental high-dose moderate to vigorous physical activity (MVPA) |
Participants will be asked to perform a high-dose (HD) (i.e., 300 minutes of moderate to vigorous physical activity (MVPA) per week) of structured exercise for 10 weeks. Exercise modality and schedule will be participant- selected and may consist of any combination of aerobic and strength training that elevates the heart rate between 64 - 95 percent of estimated heart rate max. Participants will be asked to track their activity using Fitbit. |
|
|
Experimental moderate-dose moderate to vigorous physical activity (MVPA) |
Participants will be asked to perform a moderate-dose (MD) (i.e., 150 minutes of moderate to vigorous physical activity (MVPA) per week) of structured exercise for 10 weeks. Exercise modality and schedule will be participant- selected and may consist of any combination of aerobic and strength training that elevates the heart rate between 64 - 95 percent of estimated heart rate max. Participants will be asked to track their activity using Fitbit. |
|
|
Experimental walking attention control |
Participants will be provided sleep education material and will be asked to perform 15 minutes of leisure walking three times per week. This exercise intensity does not meet the recommended volume of exercise necessary for health benefits. Instructing participants to walk will reduce the likelihood that participants will undertake a more vigorous exercise routine. Participants will be asked to track their sleep each night using Fitbit. |
|
Recruiting Locations
More Details
- Status
- Recruiting
- Sponsor
- University of Central Florida
Detailed Description
This 10-week randomized single-blind controlled trial will consist of an exercise intervention and attention control condition. A two-week familiarity trial period will be followed by 8 weeks of structured exercise. Objectively measured physical activity will be remotely monitored via Fitbit to examine its effect on depressive symptoms in sedentary young adult college students. Approximately 48 enrolled college students ages 18 - 25 will be recruited for the proposed study and randomized with a 1:1:1 allocation to one of the following conditions: 1. high-dose (HD) moderate to vigorous physical activity (MVPA) (n=16) 2. moderate-dose (MD moderate to vigorous physical activity (MVPA) (n=16) 3. a walking (W) attention control (n=16)
