Anxiety & Depression Association of America

Sensory Synchronized Imaging and Neuromodulation

Purpose

The purpose of this research study is to better understand the relationship between the type of brain stimulation used and how it changes brain activity in adult military Veterans. The goal is to use this understanding to develop new, personalized brain stimulation. The investigators evaluate brain changes from different types of transcranial magnetic brain stimulation (TMS).

Condition

Major Depressive Disorder

Eligibility

Eligible Ages: Over 18 Years
Eligible Genders: All
Accepts Healthy Volunteers: Yes

Inclusion Criteria

Men and women, ages 18 years and up - English speaking - Military Veterans

Exclusion Criteria

Those with a contraindication for MRIs (e.g. implanted metal) - History of head trauma with loss of consciousness - History of seizures or on medications that substantially reduce seizure threshold - Neurological or uncontrolled medical disease - Active substance abuse - Currently pregnant or breastfeeding

Study Design

Phase: N/A
Study Type: Interventional
Allocation: Randomized
Intervention Model: Crossover Assignment
Primary Purpose: Basic Science
Masking: Double (Participant, Outcomes Assessor)

Arm Groups

Arm	Description	Assigned Intervention
Active Comparator Standard TMS	A series of standard TMS protocols will be delivered to determine target engagement compared to seTMS. TMS will be delivered using neuro-navigation based on participant's own MRI images. Intensity will be set to 120% of the participant's motor threshold. Participants will be monitored during the session for adverse events and/or side effects.	Device: TMS transcranial magnetic brain stimulation
Active Comparator Sensory-entrained TMS (seTMS)	Sensory entrained TMS (seTMS) is a combination of music and TMS to align brain oscillations and enhance the effects of TMS. seTMS will be delivered to determine target engagement to noninvasive seTMS brain stimulation compared to standard TMS. TMS will be delivered using neuro-navigation based on participant's own MRI images. Intensity will be set to 120% of the participant's motor threshold. Participants will be monitored during the session for adverse events and/or side effects.	Device: TMS transcranial magnetic brain stimulation

Recruiting Locations

More Details

Status: Recruiting
Sponsor: VA Office of Research and Development

Study Contact

Jessica M Ross, PhD
(530) 902-2450
jessica.ross1@va.gov

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.