Anxiety & Depression Association of America

Preliminary Efficacy Trial of a Digital Intervention for Depression and Cannabis Use

Purpose

The purpose of this study is to examine the feasibility, acceptability, and preliminary efficacy of a digital intervention for co-occurring cannabis use and depression. Participants will be randomized to complete Amplification of Positivity - Cannabis Use (AMP-C) or symptom tracking. The main outcomes will include changes in depressive symptoms and cannabis use, as well as usability ratings.

Conditions

Depression - Major Depressive Disorder
Cannabis Use Disorder
Mental Disorder

Eligibility

Eligible Ages: Over 18 Years
Eligible Sex: All
Accepts Healthy Volunteers: No

Inclusion Criteria

Aged ≥ 18 years - Resides in the United States - Able to read and understand English and willing to provide informed consent/comply with the study protocol - Moderate depressive symptom severity, as indicated by the Patient Health Questionnaire-9 (PHQ-9) - Problematic cannabis use, as indicated by the Cannabis Use Disorder Identification Test - Revised (CUDIT-R) - Current elevated anhedonia, as indicated by the PHQ-9 - Interest in receiving treatment for their cannabis use and depression - Meet criteria for current MDD and CUD per the DSM-5

Exclusion Criteria

History of a psychotic disorder or bipolar disorder type I/II - Active suicidal ideation or intent based on the Columbia-Suicide Severity Rating Scale - Current psychotherapy engagement - Changes in psychotropic medication within six weeks of the start of study

Study Design

Phase: N/A
Study Type: Interventional
Allocation: Randomized
Intervention Model: Parallel Assignment
Primary Purpose: Treatment
Masking: Single (Outcomes Assessor)

Arm Groups

Arm	Description	Assigned Intervention
Experimental Amplification of Positivity - Cannabis Use (AMP-C)		Behavioral: Amplification of Positivity - Cannabis Use (AMP-C) AMP-C is a smartphone-based digital intervention that includes activities that focus on positivity (e.g., noticing and capitalizing on positive events) to increase positive emotions, thoughts, and behaviors. The role and impact of CU on the maintenance of depression and reward dysfunction (and vice versa), is intertwined throughout the intervention.
No Intervention Symptom Tracking

Recruiting Locations

More Details

Status: Recruiting
Sponsor: Massachusetts General Hospital

Study Contact

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.