Search Clinical Trials
Before medications are approved by the U.S. Food and Drug Administration (FDA) or before certain therapy methods are widely accepted as effective, they are tested on people who volunteer to participate in a clinical trial.
Organizations across the country are looking for people like you to take part in their research studies. The list of studies below have been selected from ClinicalTrials.gov based on their inclusion of one or more of the following terms: anxiety disorders, depression, OCD, PTSD, and bipolar disorder.
The Anxiety and Depression Association of America (ADAA) is supportive of research that is conducted through clinical trials. Participating in research can potentially help change the mental health outcomes for you and others who suffer anxiety, depression, and related disorders. You may learn about new interventions/treatments that are being considered.
Read this ADAA blog about things to know and questions to ask before committing to a clinical trial.
This website page is brought to you in partnership with ResearchMatch.
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Tianeptine for Treatment Resistant Depression
New York State Psychiatric Institute
Treatment Resistant Depression
The studies will be conducted in parallel at two sites: the the Mood and Anxiety
Disorders Program at the Icahn School of Medicine at Mount Sinai (MSSM), and Stanford
Depression Research Clinic at Stanford University School of Medicine (SUSM). In addition,
MRI studies for the MSSM patients will be... expand
The studies will be conducted in parallel at two sites: the the Mood and Anxiety Disorders Program at the Icahn School of Medicine at Mount Sinai (MSSM), and Stanford Depression Research Clinic at Stanford University School of Medicine (SUSM). In addition, MRI studies for the MSSM patients will be carried out at the New York State Psychaitric Institute (NYSPI). The following procedures will be approved by the local Institutional Review Boards (IRBs) at each site, where the site PIs (Alla Landa, PhD, NYSPI, James Murrough, MD at MSSM, and Alan Schatzberg, MD at SUSM) will be responsible for overseeing conduct of the study at their respective site. Dr. Jonathan Javitch is the scientific leader of this program and holds the IND for tianeptine use in this study. Investigators will recruit 75 participants with current unipolar MDD, non-delusional, between 21-60, who have failed at least 2 two adequate treatment trials with a standard antidepressant. Patients will receive an 8-week treatment trial of tianeptine. MSSM patients will also undergo structural and task-based magnetic resonance imaging (MRI) that will be performed under Dr. Landa's direction at NYSPI in order to maintain the internal validity of the data set. MSSM subjects will be transported to NYSPI to complete neuroimaging procedures as described below. Participants will be screened for MRI clearance during their screening visit and again at NYSPI on the day of the scan. Subjects will be asked MRI screening questions to ensure that are scanning eligible. Participants will also have additional tubes of blood drawn for human whole-genomic testing. This microarray will be used to identify regions of the human genome that contribute to disease susceptibility and phenotypes. The Illumina human whole-genome array will be used to provide a comprehensive view of the genome, detects single nucleotide polymorphisms and other variations across the genome. Type: Interventional Start Date: Oct 2020 |
Multi-modal Assessment of Gamma-aminobutyric Acid (GABA) Function in Psychosis
University of Michigan
Schizophrenia
Bipolar Disorder
Healthy
Psychosis
Schizophreniform Disorders
The purpose of this study is to better understand mental illness and will test the
hypotheses that while viewing affective stimuli, patient groups will show increased blood
oxygenation level dependent (BOLD) signal by fMRI after lorazepam.
This study will enroll participants between the ages of... expand
The purpose of this study is to better understand mental illness and will test the hypotheses that while viewing affective stimuli, patient groups will show increased blood oxygenation level dependent (BOLD) signal by fMRI after lorazepam. This study will enroll participants between the ages of 16 and 60, who have a psychotic illness (such as psychosis which includes conditions like schizophrenia, schizoaffective disorder, and mood disorders). The study will also enroll eligible participants without any psychiatric illness, to compare their brains. The study will require participants to have 3-4 sessions over a few weeks. The initial assessments (may be over two visits) will include a diagnostic interview and several questionnaires (qols) to assess eligibility. Subsequently, there will will be two separate functional magnetic resonance imaging (fMRI) sessions in which lorazepam or placebo will be given prior to the MRI. During the fMRI the participants will also be asked to answer questions. Additionally, the participants will have their blood drawn, women of child bearing potential will have a urine pregnancy test, vital signs taken, and asked to complete more qols. Type: Interventional Start Date: Jan 2020 |
A Mobile Intervention for Black Individuals Who Engage in Hazardous Drinking
University of Houston
Alcohol Abuse
Anxiety
The purpose of this study is to develop and examine a culturally adapted, mobile health
application for the Android and iOS platform. The application uses a personalized
feedback intervention (PFI) designed to enhance knowledge regarding adverse
anxiety-alcohol interrelations, increase motivation... expand
The purpose of this study is to develop and examine a culturally adapted, mobile health application for the Android and iOS platform. The application uses a personalized feedback intervention (PFI) designed to enhance knowledge regarding adverse anxiety-alcohol interrelations, increase motivation and intention to reduce hazardous drinking, and reduce positive attitudes and intention regarding anxiety-related alcohol use among Black hazardous drinkers with clinical anxiety. Type: Interventional Start Date: May 2023 |
Evaluation of Family-Based Behavioral Treatments for Youth With Anxiety and Obsessive-Compulsive Disorder
Baylor College of Medicine
Obsessive-Compulsive Disorder in Children
Anxiety Disorder of Childhood
Social Anxiety Disorder of Childhood
Obsessive-Compulsive Disorder in Adolescence
Generalized Anxiety Disorder
Anxiety and obsessive-compulsive disorders are among the most common in children.
Although cognitive behavioral therapy (CBT) is an effective and evidence-based treatment
for such disorders, access to CBT is often limited. Family-based and internet-delivered
therapy is one method to increase access... expand
Anxiety and obsessive-compulsive disorders are among the most common in children. Although cognitive behavioral therapy (CBT) is an effective and evidence-based treatment for such disorders, access to CBT is often limited. Family-based and internet-delivered therapy is one method to increase access to care. The purpose of this project is to evaluate the comparative efficacy and treatment mechanisms of two lower-intensity but effective treatments for families of children with anxiety or obsessive compulsive disorder (OCD) via telehealth compared to an adapted Relaxation and Mentorship Training (RMT) intervention involving breathing exercises with a therapist. Type: Interventional Start Date: Sep 2023 |
Neurostimulation Versus Therapy for Problems With Emotions
Duke University
Emotion Regulation
Mood Disorders
Stress Disorder
Anxiety Disorders
OCD
The primary goal of this clinical trial is to evaluate the unique neural and behavioral
effects of a one-session training combining emotion regulation skills training, with
excitatory repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral
prefrontal cortex (dlPFC). The secondary... expand
The primary goal of this clinical trial is to evaluate the unique neural and behavioral effects of a one-session training combining emotion regulation skills training, with excitatory repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (dlPFC). The secondary aim is to identify key changes in the emotion regulation neural network following the combined intervention versus each of the components alone. The third aim is to explore personalized biomarkers for response to emotion regulation training. Participants will undergo brain imaging while engaging in an emotional regulation task. Participants will be randomly assigned to learn one of two emotion regulation skills. Participants will be reminded of recent stressors and will undergo different types of neurostimulation, targeted using fMRI (functional MRI) results. Participants who may practice their emotion regulation skills during neurostimulation in a one-time session. Following this training, participants will undergo another fMRI and an exit interview to assess for immediate neural and behavioral changes. Measures of emotion regulation will be assessed at a one week and a one month follow up visit. Type: Interventional Start Date: May 2023 |
Adjunctive Allogeneic Mesenchymal Stem Cells for Treatment-resistant Bipolar Depression
The University of Texas Health Science Center, Houston
Treatment-resistant Bipolar Depression
The overall objective of the investigators is to assess the therapeutic efficacy and
tolerability of Allogeneic Bone Marrow Derived Multipotent Mesenchymal Stromal Cells
(MSCs) isolated from hematogenous bone marrow for treatment of treatment-resistant
bipolar depression patient (TRBD). expand
The overall objective of the investigators is to assess the therapeutic efficacy and tolerability of Allogeneic Bone Marrow Derived Multipotent Mesenchymal Stromal Cells (MSCs) isolated from hematogenous bone marrow for treatment of treatment-resistant bipolar depression patient (TRBD). Type: Interventional Start Date: Apr 2022 |
Using Neurostimulation to Accelerate Change in Misophonia: a Pilot Study
Duke University
Misophonia
Emotion Dysregulation
Sensory Processing Disorder
Auditory Over Responsivity
Anxiety Disorder
Misophonia, the inability to tolerate certain repetitive distressing sounds that are
common, is gaining, recognition as an impairing condition. It is not a well-understood
condition and there are no known treatments. The purpose of this study is to test a new
misophonia intervention that uses emotion... expand
Misophonia, the inability to tolerate certain repetitive distressing sounds that are common, is gaining, recognition as an impairing condition. It is not a well-understood condition and there are no known treatments. The purpose of this study is to test a new misophonia intervention that uses emotion regulation strategies and different types of brain stimulation on misophonic distress. This study will examine changes in brain activity during presentation and regulation of misophonic versus distressing sounds. The study team plans to alter activity in a key area of the brain responsible for emotion regulation circuitry over 4 sessions with the goal to test if this intervention helps misophonic distress. Sixty adult participants with moderate to severe misophonia will be recruited and taught an emotion regulation skill and randomly assigned to receive one of two types of repetitive transcranial magnetic stimulation (rTMS). The study includes 9-10 visits: the remote screening visit(s), the initial MRI, the four neurostimulation sessions, the follow-up MRI, and two additional remote 1- and 3-month follow-up visits. Type: Interventional Start Date: May 2024 |
8 Week Multi-site Study of MYDAYIS® for Bipolar Depression
Mayo Clinic
Bipolar Depression
This protocol is a Phase 2 multi-site study which aims to evaluate the safety and
effectiveness of MYDAYIS® as adjunctive therapy for adults with bipolar depression.
Results from this study WILL NOT be used to contribute to an approval of MYDAYIS ®
for this indication. expand
This protocol is a Phase 2 multi-site study which aims to evaluate the safety and effectiveness of MYDAYIS® as adjunctive therapy for adults with bipolar depression. Results from this study WILL NOT be used to contribute to an approval of MYDAYIS ® for this indication. Type: Interventional Start Date: Jul 2020 |
CAMPUS Expanded "Classification and Assessment of Mental Health Performance Using Semantics Expanded"
Clarigent Health
Suicide
Suicidal
Suicide, Attempted
Suicidal Ideation
Depression
Open enrollment study to collect data for the optimization of machine learning models for
use in an app for the early detection of mental health and suicidal risk. expand
Open enrollment study to collect data for the optimization of machine learning models for use in an app for the early detection of mental health and suicidal risk. Type: Observational Start Date: Jun 2020 |
Promoting Resilience in Stroke Survivor-carepartner Dyads (ReStoreD)
University of Utah
Stroke
Depression, Anxiety
Coping Skills
Couples
Affecting nearly 800,000 people in the US every year, stroke is a leading cause of
long-term disability, and has serious consequences for stroke survivors and their
carepartners. Our project uses a scientifically rigorous efficacy study to evaluate a
remotely delivered 8-week dyadic (couples-based)... expand
Affecting nearly 800,000 people in the US every year, stroke is a leading cause of long-term disability, and has serious consequences for stroke survivors and their carepartners. Our project uses a scientifically rigorous efficacy study to evaluate a remotely delivered 8-week dyadic (couples-based) positive psychology intervention to reduce emotional distress in stroke survivors and their carepartners. If successful, couples may be better emotionally equipped to cope with the sequelae of stroke, and have better rehabilitation outcomes and quality of life. Type: Interventional Start Date: Jul 2022 |
Latino Teen Depression Treatment Study
Duke University
Depression
Despite experiencing higher rates of depressive symptoms (Center for Disease Control and
Prevention, 2020) and similar rates of Major Depressive Disorder (MDD; Substance Abuse
and Mental Health Services Administration (SAMHSA), 2019), Latino adolescents in the U.S.
are significantly less likely than... expand
Despite experiencing higher rates of depressive symptoms (Center for Disease Control and Prevention, 2020) and similar rates of Major Depressive Disorder (MDD; Substance Abuse and Mental Health Services Administration (SAMHSA), 2019), Latino adolescents in the U.S. are significantly less likely than their non-Latino White peers to receive treatment for MDD (SAMHSA, 2019). The purpose of this study is to identify a stakeholder-preferred implementation strategy that may improve psychotherapy attendance among Latino adolescents. Latino adolescent-parent dyads and healthcare providers will be recruited from healthcare settings and social media. Focus groups will be conducted with healthcare providers (n=5), and individual interviews will be conducted with Latino adolescents with a diagnosis of depression (n=15) and their parents (n=15). Type: Observational Start Date: Oct 2022 |
Initial Assessment of the Feasibility and Efficacy of a Scalable Digital CBT for Generalized Anxiety...
Boston University Charles River Campus
Anxiety Disorders
Cardiovascular Diseases
Anxiety
Health Behavior
The treatment of generalized anxiety disorder (GAD) in an accessible manner represents an
unmet need for those with cardiovascular disease (CVD), given that patients with CVD
experience numerous barriers for in-person treatment engagement. The research plan for
the proposed pilot project will entail:... expand
The treatment of generalized anxiety disorder (GAD) in an accessible manner represents an unmet need for those with cardiovascular disease (CVD), given that patients with CVD experience numerous barriers for in-person treatment engagement. The research plan for the proposed pilot project will entail: (1) open study of the acceptability of the digital intervention (N=5), followed by (2) recruitment and randomization of 90 individuals with a history of acute CVD events and clinical levels of GAD symptoms to dCBT or a waitlist (Control) condition, using a 1.5:1 allocation (dCBT:Control). Type: Interventional Start Date: Feb 2022 |
Study of Oral ABBV-932 to Assess Adverse Events and Change in Disease Activity in Adult Participants...
AbbVie
Bipolar I Disorder
Bipolar II Disorder
Bipolar disorder is a severe chronic mood disorder that affects up to 4% of the adult
population and 1.8% of the pediatric population in the United States. This study will
assess how safe and effective ABBV-932 is in treating participants with bipolar I or II
disorder.
ABBV-932 is an investigational... expand
Bipolar disorder is a severe chronic mood disorder that affects up to 4% of the adult population and 1.8% of the pediatric population in the United States. This study will assess how safe and effective ABBV-932 is in treating participants with bipolar I or II disorder. ABBV-932 is an investigational drug being developed for the treatment of depressive episodes in adult participants with bipolar I or II disorder. Study doctors put participants in 1 of 4 groups, called treatment arms. There is a 1 in 4 chance that a participant will be assigned to placebo. Around 160 adult participants with bipolar I or II disorder will be enrolled in approximately 40 sites worldwide. Participants will receive oral capsules of ABBV-932 or matching placebo once daily for 6 weeks. The treatment period will be followed by a safety follow-up (SFU) period for 4 weeks. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular weekly visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires. Type: Interventional Start Date: Oct 2024 |
Empower@Home: Hybrid Effectiveness-Implementation Randomized Controlled Trial (RCT)
University of Michigan
Depression
This study is a randomized Type I hybrid effectiveness-implementation trial aimed at
evaluating the effectiveness of Empower@Home, an internet-delivered cognitive-behavioral
therapy (CBT) program supported by aging service providers, in comparison to enhanced
usual care for homebound older adults... expand
This study is a randomized Type I hybrid effectiveness-implementation trial aimed at evaluating the effectiveness of Empower@Home, an internet-delivered cognitive-behavioral therapy (CBT) program supported by aging service providers, in comparison to enhanced usual care for homebound older adults with depressive symptoms. A total of 256 participants will be randomly assigned to either the treatment group (Empower@Home) or the control group (enhanced usual care) in a 1:1 allocation ratio, with randomization stratified by participating agencies. The primary aim of this study is to determine the clinical effectiveness of the Empower@Home program. It is hypothesized that participants receiving Empower@Home will show greater improvements in depressive symptoms at 12, 24, and 36 weeks after entering the study compared to those receiving enhanced usual care. Additionally, treatment moderators will be explored and a cost-effectiveness analysis will be conducted to assess the economic viability of the intervention. The second aim is to investigate the mechanisms of change facilitated by the intervention using a mixed-methods approach. Causal mediation analysis will examine whether the acquisition of CBT skills, reduction in cognitive distortions, and increased behavioral activation, as well as participant engagement and the therapeutic alliance with the coach, mediate the treatment effects. Qualitative interviews with participants will be conducted to provide deeper insights into these mechanisms and enhance the interpretation of the mediation analysis. The third aim focuses on evaluating the implementation process using the updated Consolidated Framework for Implementation Research (CFIR). This will involve a qualitative process evaluation to identify barriers and facilitators to the implementation of Empower@Home, drawing on perspectives from multiple stakeholders. Type: Interventional Start Date: Oct 2024 |
Psilocybin Therapy for Depression in Parkinson's Disease
Joshua Woolley, MD, PhD
Parkinson Disease
Depression
The purpose of this study is to understand whether people with Parkinson's Disease and
depression have improvement in their symptoms after psilocybin therapy. expand
The purpose of this study is to understand whether people with Parkinson's Disease and depression have improvement in their symptoms after psilocybin therapy. Type: Interventional Start Date: Aug 2024 |
Evaluating Procedures for a Study of the AYA Survivors Coping and Emotional Needs Toolkit
East Carolina University
Depression
Cancer
Adolescent
Young Adult
Adult
The investigators developed a digital intervention that aims to help adolescent and young
adult cancer survivors (AYAs) manage symptoms of depression. This tool includes daily
mood tracking, a psychoeducational module about cancer and depression, four components
that are based on evidence-based interventions... expand
The investigators developed a digital intervention that aims to help adolescent and young adult cancer survivors (AYAs) manage symptoms of depression. This tool includes daily mood tracking, a psychoeducational module about cancer and depression, four components that are based on evidence-based interventions for depression. The goal of this study is to evaluate the acceptability of procedures for a future trial in which the investigators will test which component or combination of components meaningfully contribute to improvements in depressive symptoms among AYAs. Additionally, the investigators will evaluate study feasibility as well as intervention acceptability, satisfaction, usability, and engagement. Type: Interventional Start Date: Oct 2024 |
Adolescent Mood During Puberty and Testosterone
University of North Carolina, Chapel Hill
Adolescent Depression
Starting at puberty, female adolescents are nearly three-times more likely to develop
internalizing disorders, like depression, while male adolescents are two-times more
likely to develop externalizing disorders, like attention deficit hyperactivity disorder
(ADHD). This divergence between the sexes... expand
Starting at puberty, female adolescents are nearly three-times more likely to develop internalizing disorders, like depression, while male adolescents are two-times more likely to develop externalizing disorders, like attention deficit hyperactivity disorder (ADHD). This divergence between the sexes during puberty suggests sex-specific pathways of risk and differential effects of sex hormones. The purpose of this research is to determine: 1) sex-specific neural and endocrine features of the pubertal transition that may mediate sex differences in adolescent mood disorders, and 2) the neurophysiological basis of susceptibility to hormone change during puberty. Type: Interventional Start Date: Aug 2023 |
A Study of a N, N-dimethyltryptamine (DMT) Analog (CYB004) in Participants with Generalized Anxiety Disorder...
Cybin IRL Limited
Generalized Anxiety Disorder
The purpose of this proof-of-concept trial is to examine the safety, tolerability, and
pharmacokinetics (PK), and preliminary clinical efficacy of CYB004 participants with GAD. expand
The purpose of this proof-of-concept trial is to examine the safety, tolerability, and pharmacokinetics (PK), and preliminary clinical efficacy of CYB004 participants with GAD. Type: Interventional Start Date: May 2024 |
Effect of Vagal Nerve Stimulation on Gastric Motor Functions
Mayo Clinic
Epilepsy
Depression
The specific aim of this study is to compare simultaneous assessment of gastric emptying
and gastric accommodation in response to the same caloric meal before and three months
after activation of left cervical VNS. Our hypothesis is that cervical VNS increases
gastric accommodation and accelerates... expand
The specific aim of this study is to compare simultaneous assessment of gastric emptying and gastric accommodation in response to the same caloric meal before and three months after activation of left cervical VNS. Our hypothesis is that cervical VNS increases gastric accommodation and accelerates gastric emptying. Type: Interventional Start Date: Nov 2024 |
Unified Protocol: Community Connections
University of Miami
Mental Health Issue
Anxiety Disorder
Depressive Disorder
Parenting
The purpose of this study is to administer the Unified Protocols for Transdiagnostic
Treatment of Emotional Disorders in Children (UP-C) and Adolescents (UP-A) to youth and
participants' parents and to examine the efficacy and outcomes of the treatment using
standardized measures, questionnaires,... expand
The purpose of this study is to administer the Unified Protocols for Transdiagnostic Treatment of Emotional Disorders in Children (UP-C) and Adolescents (UP-A) to youth and participants' parents and to examine the efficacy and outcomes of the treatment using standardized measures, questionnaires, interviews. The UP-C and the UP-A are cognitive-behavioral therapies to treat emotional disorders. Type: Interventional Start Date: Sep 2023 |
Standardized Yoga & Meditation Program for Stress Reduction for Adolescents With Irritable Bowel Syndrome
The Cooper Health System
Irritable Bowel Syndrome
Anxiety
Quality of Life
Irritable Bowel Syndrome (IBS) is the most common cause of recurrent abdominal pain in
children. IBS is a functional gastrointestinal disorder that is linked to motor and
sensory physiology, as well as the central nervous system, that presents as abdominal
pain with abnormal defecation patterns. This... expand
Irritable Bowel Syndrome (IBS) is the most common cause of recurrent abdominal pain in children. IBS is a functional gastrointestinal disorder that is linked to motor and sensory physiology, as well as the central nervous system, that presents as abdominal pain with abnormal defecation patterns. This discomfort leads to emotional stress, decreased quality of life, and anxiety. The study proposes that yoga and mindfulness will decrease anxiety and increase quality of life for patients with IBS. The aim of this study is to measure the impact of a brief, at-home, 6-week twice per week Standardized Yoga & Meditation Program for Stress Reduction program on anxiety, IBS symptoms, and quality of life in children ages 12-21 diagnosed with IBS. Type: Interventional Start Date: Dec 2020 |
Reducing Suicide Risk in Adolescents and Young Adults Via a Psychobehavioral Intervention to Regularize...
Yale University
Bipolar Disorder
Major Depressive Disorder
Mood Disorders
Suicide
Suicidal Ideation
The purpose of this study is to advance a non-pharmacologic suicide preventive
intervention with wide dissemination potential as an innovative high-yield solution to
reduce suicide rates. The investigators aim to achieve this with this study of Brain
Emotion Circuitry Self-Monitoring and Regulation... expand
The purpose of this study is to advance a non-pharmacologic suicide preventive intervention with wide dissemination potential as an innovative high-yield solution to reduce suicide rates. The investigators aim to achieve this with this study of Brain Emotion Circuitry Self-Monitoring and Regulation Therapy for Daily Rhythms (BE-SMART-DR), that provides self-directed strategies to regularize sleep and other DRs to reduce short-term suicide risk that can be used lifelong to potentially also reduce long-term suicide risk. Type: Interventional Start Date: Apr 2022 |
Feasibility Study of Oral Ketamine Versus Placebo for the Treatment of Anxiety in Patients with Pancreatic...
Cedars-Sinai Medical Center
Anxiety
Pancreatic Cancer
This is a prospective, single center, double blind, randomized, crossover feasibility
study of oral ketamine versus placebo for the treatment of anxiety in patients with
pancreatic cancer currently receiving or within 12 weeks of receiving cancer targeted
therapy. The primary objective is to determine... expand
This is a prospective, single center, double blind, randomized, crossover feasibility study of oral ketamine versus placebo for the treatment of anxiety in patients with pancreatic cancer currently receiving or within 12 weeks of receiving cancer targeted therapy. The primary objective is to determine the feasibility of enrolling subjects and treatment adherence. The secondary objectives are to describe the safety and tolerability. Exploratory objectives are to assess the effect of ketamine/placebo on Depression, Anxiety, Physical Function, Pain Interference, Pain Intensity, Fatigue, Sleep Disturbance, and Ability to Participate in Social Roles and Activities as measured by PROMIS Anxiety Short Form 7a and the PROMIS-29 Profile v2.1 of Patient Reported Outcomes, as well as changes in circulatory inflammatory cytokines, blood glutamine levels, and other biomarkers of anxiety and/or depression. Type: Interventional Start Date: Oct 2022 |
Testing FIRST in Youth Outpatient Psychotherapy
Harvard University
Anxiety
Depression
Trauma
Behavior Problem
The study will compare the impact FIRST (a transdiagnostic treatment built upon five
empirically supported principles of change) versus usual care outpatient psychotherapy on
youths' mental health outcomes and a candidate mechanism of change: regulation of
negative emotions. expand
The study will compare the impact FIRST (a transdiagnostic treatment built upon five empirically supported principles of change) versus usual care outpatient psychotherapy on youths' mental health outcomes and a candidate mechanism of change: regulation of negative emotions. Type: Interventional Start Date: Sep 2021 |
Fitness for Brain Optimization for Late-Life Depression
University of Pittsburgh
Depression in Old Age
Cognitive impairment and brain abnormalities are common and persist after depression
remission in those with Late Life Depression (LLD), compounding dementia risk in both
individuals with acute and remitted LLD (rLLD). In this study, investigators will examine
systemic neural and cognitive benefits... expand
Cognitive impairment and brain abnormalities are common and persist after depression remission in those with Late Life Depression (LLD), compounding dementia risk in both individuals with acute and remitted LLD (rLLD). In this study, investigators will examine systemic neural and cognitive benefits of aerobic exercise training in older adults with remitted LLD. This will generate preliminary data regarding neural targets of aerobic exercise training that may translate to cognitive benefits in those with rLLD, a population who remains at high risk for dementia despite successful treatment of depression. Type: Interventional Start Date: Aug 2021 |
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