Evaluation of Association Between Testosterone Levels, Dementia, and Adverse Mental Health Outcomes
Purpose
This study evaluates the association between testosterone levels and risk of dementia and adverse mental health outcomes (e.g. depression and anxiety). It is not known whether low testosterone levels may be associated with an increased risk of dementia. Learning about the association between testosterone levels and risk of dementia may help determine the long-term effects of androgen deprivation therapy and may help improve quality of life.
Conditions
- Anxiety Disorder
- Depression
- Genetic Disorder
- Hematopoietic and Lymphoid Cell Neoplasm
- Malignant Solid Neoplasm
Eligibility
- Eligible Ages
- All ages
- Eligible Genders
- All
- Accepts Healthy Volunteers
- Yes
Criteria
Inclusion Criteria:
- Have volunteered to participate in institutional or national biobanks, mainly the UK
Biobank and the Kaiser Permanente Research Bank, and those that have previously
participated in studies that resulted in de-identified clinical and genetic data
being make available on public archives, mainly the database of Genotypes and
Phenotypes (dbGaP)
- No special populations (adults unable to consent, individuals not yet adults,
pregnant women, or prisoners)
Study Design
- Phase
- Study Type
- Observational
- Observational Model
- Case-Control
- Time Perspective
- Retrospective
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
| Observational (biobank review) | Patients' records from institutional or national biobanks are reviewed. |
|
Recruiting Locations
More Details
- Status
- Recruiting
- Sponsor
- M.D. Anderson Cancer Center
Study Contact
Detailed Description
PRIMARY OBJECTIVE: I. To use a Mendelian randomization study design to determine whether genetically predicted decreased testosterone levels are associated with an increased risk of dementia. SECONDARY OBJECTIVE: I. To examine whether genetically predicted decreased testosterone levels are associated with worse cognitive function and adverse mental health outcomes. OUTLINE: Patients' records from institutional or national biobanks are reviewed.
