Anxiety & Depression Association of America

Transdiagnostic Cognitive Biomarkers

Purpose

The overall objective of this study is to determine the feasibility of identifying transdiagnostic biomarkers of cognitive function mediated by neuromodulation of the dorsolateral prefrontal cortex that are translatable across disease groups in order to more accurately phenotype clusters of cognitive dysfunction. Completing behavioral paradigms with electrophysiology and TMS is a challenging frontier. This study focuses on the feasibility of such an endeavor for those with chronic pain or depression as well as healthy controls.

Conditions

Pain
Depression

Eligibility

Eligible Ages: Over 18 Years
Eligible Genders: All
Accepts Healthy Volunteers: Yes

Inclusion Criteria

Have access to the online study platform.

Exclusion Criteria

under 18, non-English speaking Arm 2: pain and depression: Inclusion Criteria: - Pain or depression Exclusion Criteria: - pregnant women

Study Design

Phase: N/A
Study Type: Interventional
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Intervention Model Description: Feasibility study
Primary Purpose: Diagnostic
Masking: None (Open Label)

Arm Groups

Arm	Description	Assigned Intervention
Active Comparator Healthy Comparison Group	Behavioral tasks and surveys online.	Behavioral: Computer game/task N-back, COGED, PacMan game, Bandit task, Websurf task. Other names: Behavioral tasks online and in-person. Behavioral: Health surveys online Health surveys to study themes like pain, sleep, depression and anxiety, and PTSD. Other names: PHQ-9, MASQ, GAD-7
Experimental Pain/Depression patients from clinic	MRI, TMS and EEG, and behavioral tasks and surveys online.	Behavioral: Computer game/task N-back, COGED, PacMan game, Bandit task, Websurf task. Other names: Behavioral tasks online and in-person. Behavioral: Health surveys online Health surveys to study themes like pain, sleep, depression and anxiety, and PTSD. Other names: PHQ-9, MASQ, GAD-7

Recruiting Locations

More Details

Status: Recruiting
Sponsor: University of Minnesota

Study Contact

David Darrow
(612) 624-6666
hdlab@umn.edu

Detailed Description

This study aims to test the feasibility of procedures aimed at discovering transdiagnostic biomarkers for cognitive impairment in chronic pain and depression. Fifteen healthy control participants and 15 participants from each disease group (chronic pain, depression) will be recruited. Using a task-based fmri, TMS will be targeted for priming of the Left DLPFC. EEG will be used during our behavioral paradigm to compare changes in DLPFC function before and after primed TMS.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.